【摘要】：目的:觀察陰虛陽(yáng)亢型高血壓患者與西北燥證罹患者血清AQP1、尿液AQP2濃度的變化,探討AQP1、AQP2與新疆地區(qū)高血壓病、西北燥證發(fā)病機(jī)理中的內(nèi)在聯(lián)系。方法:共收集120例高血壓患者與60例體檢健康者,分為6組。組1為罹患西北燥證的陰虛陽(yáng)亢型高血壓患者,組2為罹患西北燥證的非陰虛陽(yáng)亢型高血壓患者,組3為未罹患西北燥證的陰虛陽(yáng)亢型高血壓患者,組4為未罹患西北燥證的非陰虛陽(yáng)亢型高血壓患者,組5為罹患西北燥證的體檢健康者,組6為未罹患西北燥證的體檢健康者。每組各30人。收集所有受試者的血液、尿液標(biāo)本,用ELISA法檢測(cè)血清AQP1及尿液AQP2的濃度,分析各組間血清AQP1及尿液AQP2的濃度變化。結(jié)果:1、高血壓組與體檢健康組比較,AQP1濃度降低、AQP2濃度增高,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05)。2、罹患西北燥證的高血壓組與未罹患西北燥證的高血壓組比較,AQP1濃度降低差異具有統(tǒng)計(jì)學(xué)意義(P0.05),AQP2濃度差異無(wú)統(tǒng)計(jì)學(xué)意義。3、陰虛陽(yáng)亢型高血壓組與非陰虛陽(yáng)亢型高血壓組比較,AQP1濃度降低、AQP2濃度增高,差異均具有統(tǒng)計(jì)學(xué)意義(P0.05)。4、6組間血清AQP1濃度的兩兩比較結(jié)果:組6血清AQP1濃度明顯高于其余5組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。組4分別與組1、組2、組3、組5對(duì)比,血清AQP1濃度明顯偏高,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。組1、組2、組3、組5之間的兩兩對(duì)比差異無(wú)統(tǒng)計(jì)學(xué)意義。5、6組間尿液AQP2濃度兩兩比較的結(jié)果:組1、組2、組3、組4分別與組5、組6對(duì)比,尿液AQP2濃度明顯偏高,差異具有統(tǒng)計(jì)學(xué)意義(P0.05);組1、組2、組3之間相互對(duì)比,尿液AQP2濃度無(wú)統(tǒng)計(jì)學(xué)差異。6、血清AQP1濃度與尿液AQP2濃度呈負(fù)相關(guān)關(guān)系。結(jié)論:1、在高血壓組中AQP1濃度降低、AQP2濃度升高,提示AQP1、AQP2可能參與高血壓病的發(fā)生與發(fā)展。2、在高血壓患者中罹患西北燥證組的AQP1濃度低于未罹患西北燥證組,在體檢健康者中罹患西北燥證組的AQP1濃度低于未罹患西北組,提示人體內(nèi)AQP1的低表達(dá)與西北燥證的發(fā)生有關(guān)。3、高血壓陰虛陽(yáng)亢組與高血壓非陰虛陽(yáng)亢組比較,AQP1濃度降低、AQP2濃度升高,提示AQP1濃度的減少、AQP2濃度的增加可能是陰虛陽(yáng)亢型高血壓的發(fā)生誘因與加重因素。4、尿液AQP2的濃度與高血壓關(guān)系密切,與西北燥證的關(guān)系不大。
[Abstract]:Objective: to observe the changes of serum AQP1, urine AQP2 concentration in patients with hyperactivity of yang due to yin deficiency and patients with northwest dryness syndrome, and to explore the relationship between AQP1,AQP2 and hypertension in Xinjiang and the pathogenesis of northwest dryness syndrome. Methods: 120 patients with hypertension and 60 healthy persons were divided into 6 groups. Group 1 was hypertension with yin deficiency and yang hyperactivity, group 2 was hypertension without yin deficiency and yang hyperactivity, and group 3 was hypertension with yin deficiency and yang hyperactivity without northwest dryness syndrome. Group 4 was a non-yin deficiency hyperactivity type hypertension patient without northwest dryness syndrome, group 5 was a healthy person with northwest dryness syndrome, group 6 was a healthy person without northwest dryness syndrome. There are 30 people in each group. The blood and urine samples of all the subjects were collected. The serum AQP1 and urine AQP2 were detected by ELISA method. The changes of serum AQP1 and urine AQP2 were analyzed. Results: 1. The concentration of AQP1 and the concentration of AQP2 in hypertension group were lower than those in physical health group, the difference was statistically significant (P0.05). The difference between hypertension group with northwest dryness syndrome and hypertension group without northwest dryness syndrome was significant (P0.05). The decrease of AQP1 concentration was statistically significant (P0.05), but there was no significant difference in AQP2 concentration. 3. Compared with non-yin deficiency hyperactivity type hypertension group, AQP1 concentration decreased and AQP2 concentration increased in hyperactivity of yin deficiency and yang group. The difference was statistically significant (P0.05). 4The results of pairwise comparison of serum AQP1 concentration among 6 groups: the serum AQP1 concentration of group 6 was significantly higher than that of the other 5 groups, the difference was statistically significant (P0.05). Compared with group 1, group 2, group 3 and group 5, serum AQP1 concentration in group 4 was significantly higher than that in group 1, group 2, group 3 and group 5 (P0.05). There was no significant difference in urine AQP2 concentration between group 1, group 2, group 3 and group 5. The results of comparison of urine AQP2 concentration between group 1, group 2, group 3 and group 4 were significantly higher than those in group 5, group 1, group 2, group 3 and group 4, respectively. The difference was statistically significant (P0.05). There was no significant difference in urine AQP2 concentration between group 1, group 2 and group 3. 6. There was a negative correlation between serum AQP1 concentration and urine AQP2 concentration. Conclusion: 1. The concentration of AQP1 decreased and the concentration of AQP2 increased in hypertension group, suggesting that AQP1,AQP2 might be involved in the occurrence and development of hypertension. 2. The AQP1 concentration in patients with northwest dryness syndrome was lower than that in patients without northwest dryness syndrome. The concentration of AQP1 in the group with northwest dryness syndrome was lower than that in the group without northwest dryness, suggesting that the low expression of AQP1 in the human body was related to the occurrence of northwest dryness syndrome. 3. The concentration of AQP1 in hypertensives with yin deficiency and hyperactivity of yang was lower than that in the group without hyperactivity of yang due to deficiency of yin. The increase of AQP2 concentration suggests that the decrease of AQP1 concentration and the increase of AQP2 concentration may be the inducement and aggravation factor of hypertension with yin deficiency and yang hyperactivity. 4. The concentration of AQP2 in urine is closely related to hypertension, but not related to dryness syndrome in Northwest China.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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