【摘要】：目的:通過探究慢性腎小球腎炎(CKD 1-3期)患者的血尿酸水平和性別、年齡、高血壓病史、CKD分期、中醫(yī)證型之關(guān)系,以期為伴有高尿酸血癥的慢性腎小球腎炎患者的中醫(yī)治療提供參考依據(jù)。材料與方法:收集2014年1月份至2015年12月份在遼寧中醫(yī)藥大學附屬醫(yī)院腎內(nèi)科診斷為慢性腎小球腎炎患者(CKD 1-3期)的臨床信息,共計97例,并且根據(jù)血尿酸的不同程度,分為正常尿酸組43例,高尿酸血癥組54例,采用統(tǒng)計學方法分析兩組病例性別、年齡、高血壓病史、CKD分期以及中醫(yī)的證型特點。結(jié)果:1.慢性腎小球腎炎患者(CKD 1-3期)高尿酸血癥組和正常尿酸組在性別、年齡分布方面差異無統(tǒng)計學意義(P0.05)。2.慢性腎小球腎炎患者(CKD 1-3期)高尿酸血癥組的高血壓患病率明顯高于正常血尿酸組,差異具有統(tǒng)計學意義(P0.05)。3.慢性腎小球腎炎患者(CKD 1-3期)高尿酸血癥組和正常尿酸組在CKD分期方面差異具有統(tǒng)計學意義(P0.05)。4.慢性腎小球腎炎患者(CKD 1-3期)高尿酸血癥組的濕熱證發(fā)生率高于正常尿酸組,差異具有統(tǒng)計學意義(P0.05)。結(jié)論:1.血尿酸水平升高和高血壓疾病之間通過多種機制相互作用,形成惡性循環(huán),加速腎臟功能損害,所以應(yīng)該積極控制慢性腎小球腎炎患者的血尿酸水平及血壓水平。2.血尿酸水平升高不僅標志著腎臟功能的減退,而且在慢性腎臟病的病程中發(fā)揮重要作用,所以控制慢性腎小球腎炎患者血尿酸水平對延緩病情進展具有不容忽視的意義。3.對于合并高尿酸血癥的慢性腎小球腎炎患者可酌情運用具有清熱化濕功效的中藥,有利于緩解濕熱證的臨床表現(xiàn),減輕血尿酸程度,延緩病變進展。
[Abstract]:Objective: to investigate the relationship between serum uric acid level, sex, age, history of hypertension, CKD stage and TCM syndromes in patients with chronic glomerulonephritis (CKD 1-3). In order to provide reference for the treatment of chronic glomerulonephritis with hyperuricemia. Materials and methods: 97 patients with chronic glomerulonephritis (CKD 1-3) were collected from January 2014 to December 2015 in the Department of Nephrology, affiliated Hospital of Liaoning University of traditional Chinese Medicine. The patients were divided into normal uric acid group (n = 43) and hyperuricemia group (n = 54). Sex, age, hypertension history, CKD stage and TCM syndromes were analyzed by statistical method. Results: 1. There was no significant difference in sex and age distribution between hyperuricemia group and normal uric acid group in patients with chronic glomerulonephritis (CKD 1-3 stage) (P0.05). The prevalence of hypertension in patients with chronic glomerulonephritis (CKD 1-3 stage) with hyperuricemia was significantly higher than that with normal uric acid (P0.05). Chronic glomerulonephritis patients (CKD 1-3) hyperuricemia group and normal uric acid group in CKD staging differences were statistically significant (P0.05). 4. The incidence of damp-heat syndrome in patients with chronic glomerulonephritis (CKD 1-3 stage) with hyperuricemia was higher than that in normal uric acid group (P0.05). Conclusion: 1. The increase of serum uric acid level and hypertension through a variety of mechanisms of interaction, forming a vicious circle, accelerate the damage of renal function, so we should actively control the level of blood uric acid and blood pressure in patients with chronic glomerulonephritis. 2. 2. The elevated level of uric acid not only marks the decline of renal function, but also plays an important role in the course of chronic kidney disease. Therefore, it is important to control the level of uric acid in patients with chronic glomerulonephritis to delay the progression of the disease. 3. For patients with chronic glomerulonephritis complicated with hyperuricemia, Chinese medicine with the effect of clearing heat and removing dampness can be used as appropriate, which is helpful to alleviate the clinical manifestation of damp-heat syndrome, reduce the degree of blood uric acid, and delay the progress of pathological changes.
【學位授予單位】：遼寧中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R277.5
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本文編號：2402259