基于“虛邪瘀”理論的強(qiáng)直性脊柱炎中醫(yī)證候規(guī)范化研究
發(fā)布時間：2018-12-11 00:34
【摘要】：目的：借助臨床流行病學(xué)的方法，將強(qiáng)直性脊柱炎的臨床信息進(jìn)行收集整理，利用相關(guān)統(tǒng)計學(xué)方法從“虛邪瘀”理論角度分析強(qiáng)直性脊柱炎的中醫(yī)證候特點(diǎn)，初步建立基于“虛邪瘀”理論的強(qiáng)直性脊柱炎中醫(yī)證候分類及辨證標(biāo)準(zhǔn)，為臨床強(qiáng)直性脊柱炎的中醫(yī)藥治療和研究提供依據(jù)。 方法：通過檢索相關(guān)文獻(xiàn)、閱讀專著、咨詢專家和預(yù)調(diào)查等方法,設(shè)計強(qiáng)直性脊柱炎臨床信息調(diào)查表,對2013年4月至2013年12月在河南風(fēng)濕病醫(yī)院首次門診及住院的206例強(qiáng)直性脊柱炎患者進(jìn)行臨床流行病學(xué)調(diào)查,最后將收集的資料輸入數(shù)據(jù)庫，采用SPSS19.0統(tǒng)計軟件進(jìn)行數(shù)據(jù)處理，運(yùn)用描述性分析、頻數(shù)分析、因子分析和聚類分析等統(tǒng)計方法,從“虛邪瘀”理論角度分析強(qiáng)直性脊柱炎的中醫(yī)證候特點(diǎn)，初步建立基于“虛邪瘀”理論的強(qiáng)直性脊柱炎中醫(yī)證候分類及辨證標(biāo)準(zhǔn)。 結(jié)果：1.納入本次研究的強(qiáng)直性脊柱炎患者共206例，其中男性患者174例，女性患者32例，男女比例約5.4：1�；颊叩陌l(fā)病年齡主要集中在10歲到30歲之間且病程較長以2年到20年居多，發(fā)病原因多為勞累、受風(fēng)寒濕和外傷，首次發(fā)病季節(jié)多在夏季和冬季。2.簡化數(shù)據(jù)縮減變量后，經(jīng)因子分析得到8個符合中醫(yī)證候診斷的公因子，它們基本反映了強(qiáng)直性脊柱炎的病因病機(jī)。聚類分析將變量聚為3類，，結(jié)合因子分析所得到的8個公因子并運(yùn)用“虛邪瘀”理論將強(qiáng)直性脊柱炎的中醫(yī)證候分為3類：第1類腎陰虛內(nèi)熱、濕瘀痹阻證；第2類邪瘀痹阻、腎虛肝郁證；第3類腎陽虛寒凝、瘀血阻絡(luò)證。 結(jié)論：本研究在“虛邪瘀”理論的指導(dǎo)下，采用因子分析和聚類分析等統(tǒng)計學(xué)方法，從“虛邪瘀”理論角度將強(qiáng)直性脊柱炎的中醫(yī)證候分為3類：第1類腎陰虛內(nèi)熱、濕瘀痹阻證；第2類邪瘀痹阻、腎虛肝郁證；第3類腎陽虛寒凝、瘀血阻絡(luò)證。
[Abstract]:Objective: to collect and organize the clinical information of ankylosing spondylitis by means of clinical epidemiology, and to analyze the characteristics of TCM syndromes of ankylosing spondylitis from the theory of "deficiency and evil stasis". To establish the TCM syndrome classification and syndrome differentiation standard of ankylosing spondylitis based on the theory of "deficiency pathogenic stasis", and to provide the basis for the treatment and research of clinical ankylosing spondylitis with traditional Chinese medicine. Methods: a questionnaire for clinical information of ankylosing spondylitis was designed by searching related literature, reading monographs, consulting experts and pre-investigation. From April 2013 to December 2013, 206 patients with ankylosing spondylitis who were first outpatient and hospitalized in Henan Rheumatological Hospital were investigated by clinical epidemiology. Finally, the collected data were input into the database, and the data were processed by SPSS19.0 software. By means of descriptive analysis, frequency analysis, factor analysis and cluster analysis, the characteristics of TCM syndromes of ankylosing spondylitis were analyzed from the theory of "deficiency and evil stasis". To establish the TCM syndrome classification and syndrome differentiation standard of ankylosing spondylitis based on the theory of deficiency and evil stasis. Results: 1. A total of 206 patients with ankylosing spondylitis were included in the study, including 174 men and 32 women, with a ratio of 5. 4 to 1. The onset age of the patients was mainly between 10 and 30 years of age and the course of disease was longer than 2 to 20 years. The most common cause was fatigue, wind, cold, dampness and trauma, and the first onset season was mostly in summer and winter. After simplified data reduction variables, eight common factors were obtained by factor analysis, which reflected the etiology and pathogenesis of ankylosing spondylitis. Cluster analysis divided variables into three categories, combined with the eight common factors obtained by factor analysis and the theory of "deficiency and evil stasis", the TCM syndrome of ankylosing spondylitis was divided into three categories: the first type of kidney yin deficiency internal heat, dampness stasis obstruction syndrome; Type 2, stagnation of pathogenic stasis, kidney deficiency and liver stagnation syndrome, the third type of kidney yang deficiency cold coagulation, blood stasis blocking collaterals syndrome. Conclusion: under the guidance of the theory of "deficiency and evil stasis", this study used factor analysis and cluster analysis to classify the TCM syndromes of ankylosing spondylitis into three categories: type 1, internal heat of kidney yin deficiency, and so on, from the perspective of "deficiency of pathogenic blood stasis" theory, the TCM syndromes of ankylosing spondylitis can be divided into three categories. Syndrome of dampness and stasis obstruction; Type 2, stagnation of pathogenic stasis, kidney deficiency and liver stagnation syndrome, the third type of kidney yang deficiency cold coagulation, blood stasis blocking collaterals syndrome.
【學(xué)位授予單位】：河南中醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R259
本文編號：2371517
[Abstract]:Objective: to collect and organize the clinical information of ankylosing spondylitis by means of clinical epidemiology, and to analyze the characteristics of TCM syndromes of ankylosing spondylitis from the theory of "deficiency and evil stasis". To establish the TCM syndrome classification and syndrome differentiation standard of ankylosing spondylitis based on the theory of "deficiency pathogenic stasis", and to provide the basis for the treatment and research of clinical ankylosing spondylitis with traditional Chinese medicine. Methods: a questionnaire for clinical information of ankylosing spondylitis was designed by searching related literature, reading monographs, consulting experts and pre-investigation. From April 2013 to December 2013, 206 patients with ankylosing spondylitis who were first outpatient and hospitalized in Henan Rheumatological Hospital were investigated by clinical epidemiology. Finally, the collected data were input into the database, and the data were processed by SPSS19.0 software. By means of descriptive analysis, frequency analysis, factor analysis and cluster analysis, the characteristics of TCM syndromes of ankylosing spondylitis were analyzed from the theory of "deficiency and evil stasis". To establish the TCM syndrome classification and syndrome differentiation standard of ankylosing spondylitis based on the theory of deficiency and evil stasis. Results: 1. A total of 206 patients with ankylosing spondylitis were included in the study, including 174 men and 32 women, with a ratio of 5. 4 to 1. The onset age of the patients was mainly between 10 and 30 years of age and the course of disease was longer than 2 to 20 years. The most common cause was fatigue, wind, cold, dampness and trauma, and the first onset season was mostly in summer and winter. After simplified data reduction variables, eight common factors were obtained by factor analysis, which reflected the etiology and pathogenesis of ankylosing spondylitis. Cluster analysis divided variables into three categories, combined with the eight common factors obtained by factor analysis and the theory of "deficiency and evil stasis", the TCM syndrome of ankylosing spondylitis was divided into three categories: the first type of kidney yin deficiency internal heat, dampness stasis obstruction syndrome; Type 2, stagnation of pathogenic stasis, kidney deficiency and liver stagnation syndrome, the third type of kidney yang deficiency cold coagulation, blood stasis blocking collaterals syndrome. Conclusion: under the guidance of the theory of "deficiency and evil stasis", this study used factor analysis and cluster analysis to classify the TCM syndromes of ankylosing spondylitis into three categories: type 1, internal heat of kidney yin deficiency, and so on, from the perspective of "deficiency of pathogenic blood stasis" theory, the TCM syndromes of ankylosing spondylitis can be divided into three categories. Syndrome of dampness and stasis obstruction; Type 2, stagnation of pathogenic stasis, kidney deficiency and liver stagnation syndrome, the third type of kidney yang deficiency cold coagulation, blood stasis blocking collaterals syndrome.
【學(xué)位授予單位】：河南中醫(yī)學(xué)院
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R259
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