【摘要】：目的:觀察藥油灸、單純艾灸與常規(guī)西藥治療慢性非細(xì)菌性前列腺炎(chronic nonbacterial prostatitis,CNP)的臨床療效差異及部分作用機(jī)制。方法:將120例符合入選標(biāo)準(zhǔn)的患者隨機(jī)分為藥油灸組、灸法組和西藥組,每組40例。藥油灸組與灸法組穴取關(guān)元、中極、氣海及雙側(cè)陰陵泉、三陰交、腎俞、命門、膀胱俞、次毼、秩邊,灸法組行單純艾灸,藥油灸組用藥油外搽施灸穴位后同灸法組艾灸,每次約30 min,每日1次,腹部、背部交替進(jìn)行。西藥組口服鹽酸坦索羅辛膠囊,每次1粒,每日1次。3組均治療30 d,觀察各組治療前后及治療后1個(gè)月隨訪時(shí)美國(guó)國(guó)立衛(wèi)生院制定的慢性前列腺炎癥狀積分指數(shù)(NIH-CPSI)評(píng)分及鋅(Zinc,Zn)、C反應(yīng)蛋白(C-reactive protein,CRP)含量及前列腺液中白細(xì)胞數(shù)量(white blood cells,WBC)、卵磷脂小體計(jì)數(shù),并于治療后評(píng)價(jià)臨床療效。結(jié)果:藥油灸組治療后總有效率為90.0%(36/40),明顯高于灸法組的72.5%(29/40)和西藥組的62.5%(25/40,均P0.05)。治療后及隨訪時(shí),各組NIH-CPSI評(píng)分均低于治療前(均P0.05),且藥油灸組低于灸法組與西藥組(均P0.05);各組Zn含量均高于治療前(均P0.05),且藥油灸組高于灸法組與西藥組(均P0.05),灸法組高于西藥組(均P0.05);各組CRP含量均低于治療前(均P0.05),且藥油灸組低于灸法組與西藥組(均P0.05),灸法組低于西藥組(P0.05);各組WBC計(jì)數(shù)均低于治療前(均P0.05),且藥油灸組低于灸法組與西藥組(均P0.05);各組卵磷脂小體計(jì)數(shù)均高于治療前(均P0.05),且藥油灸組高于灸法組與西藥組(均P0.05)。上述指標(biāo)治療前后組間差值比較,藥油灸組均優(yōu)于灸法組和西藥組(均P0.05),其中Zn含量灸法組優(yōu)于西藥組(P0.05)。結(jié)論:藥油灸治療CNP臨床療效優(yōu)于單純艾灸與西藥,在改善患者臨床癥狀,升高Zn含量、卵磷脂小體計(jì)數(shù),降低CRP含量、WBC計(jì)數(shù)方面具有優(yōu)勢(shì)。
[Abstract]:Objective: to observe the difference of clinical efficacy and mechanism of herbal moxibustion, simple moxibustion and conventional western medicine in the treatment of chronic nonbacterial prostatitis (chronic nonbacterial prostatitis,CNP). Methods: 120 patients were randomly divided into three groups: moxibustion group, moxibustion group and western medicine group. The moxibustion group and moxibustion group received moxibustion on the points of Guan Yuan, middle pole, air sea and bilateral Yin Ling Quan, Sanyinjiao, Shenshu, Shengmen, Biaoshu, Suzhuo, Rank side, moxibustion group, and moxibustion group were treated with moxibustion after applying moxibustion oil outside the acupoint, the moxibustion group was moxibustion with the same moxibustion method after applying moxibustion oil. Each time about 30 min, daily, abdomen, back alternately. The western medicine group was treated with tansoloxine hydrochloride capsule once a day for 30 days. To observe the scores of chronic prostatitis symptom score (NIH-CPSI) and Zinc,Zn), C reactive protein (C-reactive protein,) developed by the National Institutes of Health before and after treatment and 1 month after treatment. The content of CRP, the number of leukocytes in prostatic fluid (white blood cells,WBC), the count of lecithin corpuscles, and the clinical effect were evaluated after treatment. Results: the total effective rate of moxibustion group was 90.0% (36 / 40), which was significantly higher than that of moxibustion group (72.5%) and western medicine group (62.5%) (P 0.05). After treatment and follow-up, the scores of NIH-CPSI in each group were lower than those before treatment (P0.05), and those in moxibustion group were lower than those in moxibustion group and western medicine group (P0.05). The content of Zn in each group was higher than that before treatment (P0.05), and the content of Zn in moxibustion group was higher than that in moxibustion group and western medicine group (P0.05), and that in moxibustion group was higher than that in western medicine group (P0.05). The content of CRP in each group was lower than that before treatment (P0.05), and the content of CRP in moxibustion group was lower than that in moxibustion group and western medicine group (P0.05), and that in moxibustion group was lower than that in western medicine group (P0.05). The number of WBC in each group was lower than that before treatment (P0.05), and the number of WBC in moxibustion group was lower than that in moxibustion group and western medicine group (P0.05). The number of lecithin bodies in each group was higher than that before treatment (P0.05), and the number of lecithin bodies in moxibustion group was higher than that in moxibustion group and western medicine group (P0.05). The difference between the above indexes before and after treatment was better in moxibustion group than in moxibustion group and western medicine group (P0.05). The content of Zn in moxibustion group was better than that in western medicine group (P0.05). Conclusion: moxibustion with medicinal oil is superior to moxibustion and western medicine in the treatment of CNP. It has advantages in improving clinical symptoms, increasing Zn content, counting lecithin body, decreasing CRP content and WBC count.
【作者單位】： 安徽中醫(yī)藥大學(xué)附屬滁州市中西醫(yī)結(jié)合醫(yī)院泌尿男科;
【基金】：2014年度安徽省衛(wèi)生計(jì)生委中醫(yī)藥科技課題:2014zy60
【分類號(hào)】：R246.9

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