【摘要】：目的:通過隨機(jī)對(duì)照試驗(yàn),觀察麻蟬四二湯治療糖尿病皮膚瘙癢癥陰虛風(fēng)燥證的的臨床療效,并對(duì)麻蟬四二湯的療效及安全性進(jìn)行客觀的評(píng)價(jià),探索有效的辨證治療思路,為臨床使用提供理論依據(jù)。方法:收集60例符合標(biāo)準(zhǔn)的試驗(yàn)受試者,按照隨機(jī)分組的方法,將60例受試者分配到治療組及對(duì)照組,每組各30例。治療組的治療方法為糖尿病基礎(chǔ)治療合麻蟬四二湯內(nèi)服,對(duì)照組的治療方法為糖尿病基礎(chǔ)治療合氯雷他定片口服,兩組均用藥4周,在用藥前后按照試驗(yàn)要求填寫皮膚瘙癢相關(guān)癥狀及體征積分表、中醫(yī)臨床證候積分表。在治療前,觀察兩組的性別、年齡、病程、血糖分布是否具有可比性。用藥4周后,觀察治療組、對(duì)照組組內(nèi)及組間皮膚瘙癢相關(guān)癥狀及體征積分變化區(qū)別及治療組與對(duì)照組組內(nèi)及組間中醫(yī)臨床證候積分變化區(qū)別。結(jié)果:1.兩組患者治療前后皮膚瘙癢相關(guān)癥狀及體征積分組內(nèi)比較,經(jīng)配對(duì)樣本t檢驗(yàn),均P㩳0.05,有顯著差異,兩組均有療效。組間比較,兩組治療前積分比較,經(jīng)獨(dú)立樣本t檢驗(yàn),P㧐0.05,組間無顯著差異,具有可比性。兩組治療后積分比較,經(jīng)獨(dú)立樣本t檢驗(yàn),P㩳0.05,有顯著差異,治療組療效優(yōu)于對(duì)照組。治療組治療后皮膚瘙癢相關(guān)癥狀及體征有效率為93.33%,對(duì)照組為73.33%,經(jīng)x2檢驗(yàn)P㩳0.05,有顯著差異,治療組優(yōu)于對(duì)照組。2.兩組患者治療前后中醫(yī)臨床證候積分組內(nèi)比較,經(jīng)配對(duì)樣本t檢驗(yàn),均P㩳0.05,有顯著差異,兩組均有療效。組間比較,兩組患者治療前糖尿病中醫(yī)臨床證候積分比較,經(jīng)獨(dú)立樣本t檢驗(yàn),P㧐0.05,組間無顯著差異,具有可比性。兩組治療后積分相比,經(jīng)獨(dú)立樣本t檢驗(yàn),P㩳0.05,有顯著差異,說明治療組療效優(yōu)于對(duì)照組。治療組治療后糖尿病中醫(yī)臨床證候有效率為96.67%,對(duì)照組為56.67%,經(jīng)x2檢驗(yàn)P㩳0.05,有顯著差異,治療組優(yōu)于對(duì)照組。結(jié)論:麻蟬四二湯能夠有效改善糖尿病皮膚瘙癢癥陰虛風(fēng)燥證的皮膚瘙癢癥狀及體征,對(duì)糖尿病中醫(yī)臨床證候也有明顯的改善作用,且療效優(yōu)于對(duì)照組。經(jīng)試驗(yàn)觀察未出現(xiàn)不良反應(yīng),因此麻蟬四二湯是治療陰虛風(fēng)燥型糖尿病皮膚瘙癢癥的安全有效的方劑。
[Abstract]:Objective: to observe the clinical effect of Maichang Sier decoction in treating the syndrome of yin deficiency and wind-dryness in diabetic skin pruritus, and to evaluate objectively the efficacy and safety of Maichang Sier decoction, and to explore the effective treatment method based on syndrome differentiation. To provide theoretical basis for clinical use. Methods: 60 subjects were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with basic diabetes treatment combined with Ma Cheng Si er Tang, while the control group was treated by oral administration of loratadine tablets, both of which were treated for 4 weeks. Fill in the symptom and sign integral form of skin pruritus and clinical syndrome integral form of traditional Chinese medicine according to the test requirements before and after medication. Before treatment, the sex, age, course of disease and blood sugar distribution of the two groups were observed to be comparable. After 4 weeks, the changes of symptoms and signs related to skin pruritus in treatment group, control group and control group were observed, and the changes of TCM clinical syndromes in treatment group and control group were compared. The result is 1: 1. The scores of symptoms and signs related to skin pruritus in the two groups were compared before and after treatment. By paired sample t test, there was significant difference between the two groups. There was no significant difference between the two groups and there was no significant difference between the two groups. The scores of the two groups after treatment were significantly different by independent sample t test, and the curative effect of the treatment group was better than that of the control group. The effective rate of pruritus related symptoms and signs was 93.33 in the treatment group and 73.33 in the control group. There was significant difference between the treatment group and the control group. Two groups of patients before and after treatment of traditional Chinese medicine clinical syndrome score group comparison, through paired samples t test, all Pu 0.05, there is significant difference, the two groups have curative effect. There was no significant difference between the two groups and there was no significant difference between the two groups. After treatment, the scores of the two groups were significantly higher than those of the control group by t test of independent sample, which indicated that the curative effect of the treatment group was better than that of the control group. The effective rate of TCM syndromes was 96.67 in the treatment group and 56.67 in the control group. There was significant difference between the treatment group and the control group after X2 test. The treatment group was superior to the control group. Conclusion: Ma Cheng Si er Tang can effectively improve the symptoms and signs of skin pruritus due to yin deficiency and wind-dryness syndrome of diabetes mellitus. It also can improve the clinical syndromes of diabetes mellitus and the curative effect is better than that of the control group. There were no adverse reactions after experimental observation, so Maichang Sier decoction is a safe and effective prescription for treating diabetic skin pruritus with yin deficiency and wind dryness.
【學(xué)位授予單位】：山西中醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259

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