自擬益腎健脾化瘀方治療絕經(jīng)后脾腎陽虛型骨質(zhì)疏松癥的臨床研究
[Abstract]:Objective to investigate the clinical effect of Yishen Jianpi Huayu recipe in treating postmenopausal osteoporosis with deficiency of spleen and kidney yang. Methods 120 postmenopausal osteoporosis patients admitted to our hospital from January 2016 to January 2017 were randomly divided into observation group (n = 60) and control group (n = 60). The control group was treated with Xianling Gu Bao capsule, the observation group with self-made prescription of tonifying kidney and spleen and removing blood stasis, and the two groups were treated for 3 months. Results after treatment, the pain of the back of the waist, the weakness of the waist and knee, the increase of nocturnal urine, the chills of the cold limbs, the burnout of the cold limbs and the total score of the two groups were significantly decreased (P0.01), but the decrease was more obvious in the observation group (P0.01). The total effective rate of the observation group was 93.33, which was significantly higher than that of the control group (80.00g / P0.01). The bone mineral density of L2P L4, femoral neck, greater trochanter of femur and Ward's triangle in both groups were significantly higher than those before treatment (P0.01), but the increase in observation group was more obvious (P0.01). Bone specific alkaline phosphatase (B-ALP) and tartrate-resistant acid phosphatase (TRACP) were significantly decreased in both groups (P0.01), especially in the observation group (P0.01). The levels of estradiol (E2) and insulin growth factor (IGF-1) in both groups were significantly higher than those before treatment (P0.01), especially in the observation group (P0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P0.05). Conclusion the self-made prescription of tonifying spleen and removing blood stasis can significantly improve the clinical symptoms of osteoporosis with deficiency of spleen and kidney yang after menopause, as well as improve bone metabolism and bone mineral density. The mechanism may be related to the increase of estrogen and IGF-1 levels.
【作者單位】： 江西省婦幼保健院婦科;江西省婦幼保健院病理科;
【基金】：江西省衛(wèi)計委科技計劃課題(20165443)
【分類號】：R259
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