津血源顆粒治療干燥綜合征合并焦慮的臨床研究
發(fā)布時(shí)間：2018-10-30 14:14
【摘要】：目的：使用津血源顆粒聯(lián)合硫酸羥氯喹(HCQ)片治療合并焦慮的干燥綜合征(SS)患者,評(píng)價(jià)治療前后患者干燥癥狀的改善情況以及焦慮情況的變化。方法：以2015年2月至2016年2月期間至江蘇省中醫(yī)院門診及病房就診的40例SS伴焦慮患者為研究對(duì)象,隨機(jī)分為治療組和對(duì)照組,兩組各20例,治療組予津血源顆粒+HCQ片口服治療,對(duì)照組僅以HCQ口服治療,觀察期為8周。使用癥狀體征量化表評(píng)價(jià)患者治療前后病情改變,分析相關(guān)實(shí)驗(yàn)室檢查指標(biāo)變化情況。并采用醫(yī)院焦慮量表(HADa)和患者焦慮自評(píng)量表(SAS)的問卷調(diào)查形式,對(duì)所納入的SS患者治療前后進(jìn)行焦慮情況評(píng)估,比較患者焦慮癥狀改善情況。結(jié)果：1.治療前患者一般情況和病情比較：兩組患者在年齡、性別和病程分布等一般情況方面無(wú)顯著性差異。在相關(guān)實(shí)驗(yàn)室指標(biāo)、中醫(yī)癥狀體征評(píng)分和焦慮評(píng)分等方面無(wú)統(tǒng)計(jì)學(xué)差異(P0.05)。2.改善患者病情方面：治療組總體有效率為85%,對(duì)照組為55%,兩組差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。兩組治療后實(shí)驗(yàn)室指標(biāo)(包括血沉、C反應(yīng)蛋白、免疫球蛋白G)方面得到明顯改善(P0.05),且津血源治療組較對(duì)照組相比,更能顯著降低ESR和CRP水平(P0.05)。在中醫(yī)癥狀體征評(píng)分方面,兩組治療后均有改善(P0.05)。津血源治療組患者口干和眼干癥狀改善具有顯著性差異。3.改善患者焦慮方面：HCQ治療組中患者HADa評(píng)分和SAS評(píng)分有下降趨勢(shì),但無(wú)統(tǒng)計(jì)學(xué)差異(P0.05),但聯(lián)合津血源治療可顯著降低患者焦慮評(píng)分(P0.05)。4.安全性指標(biāo)方面：在治療過程中,兩組均未發(fā)生不良癥狀,血、尿、糞三大常規(guī)和肝腎功能等安全性指標(biāo)也無(wú)明顯異常(P0.05)。結(jié)論：對(duì)SS伴焦慮患者,在使用HCQ治療原發(fā)病的基礎(chǔ)上,加用津血源顆粒,能更好地改善其干燥癥狀及焦慮情緒,在實(shí)驗(yàn)室指標(biāo)方面也有明顯改善,且短期內(nèi)應(yīng)用未發(fā)現(xiàn)不良反應(yīng),安全性較好。
[Abstract]:Objective: to evaluate the effect of Jinxueyuan granule combined with hydroxychloroquine sulfate (HCQ) tablets on patients with Sjogren's syndrome (SS) complicated with anxiety and to evaluate the improvement of dry symptoms and the changes of anxiety in patients with Sjogren's syndrome before and after treatment. Methods: from February 2015 to February 2016, 40 SS patients with anxiety were randomly divided into treatment group and control group, 20 cases in each group. The treatment group was treated with Jinxueyuan granule HCQ tablet orally, while the control group was treated with HCQ orally only, the observation period was 8 weeks. The symptoms and signs of the patients before and after treatment were evaluated by quantitative tables, and the changes of related laboratory indicators were analyzed. (HADa) and (SAS) were used to evaluate the anxiety of SS patients before and after treatment to compare the improvement of anxiety symptoms. The result is 1: 1. Comparison of general condition and disease condition before treatment: there was no significant difference in age, sex and course of disease between the two groups. There was no statistical difference in related laboratory indexes, TCM symptom and sign scores and anxiety scores (P0.05). The total effective rate of treatment group was 85 and that of control group was 550.The difference between the two groups was statistically significant (P0.05). The laboratory indexes (including erythrocyte sedimentation rate, C-reactive protein, immunoglobulin G) were significantly improved after treatment in both groups (P0.05), and the levels of ESR and CRP in the blood source treatment group were significantly lower than those in the control group (P0.05). In TCM symptom and sign score, the two groups were improved after treatment (P0.05). There was significant difference in the improvement of dry mouth and dry eye symptoms in the blood source treatment group. Improve the anxiety of patients: in the HCQ treatment group, the HADa score and SAS score decreased, but there was no statistical difference (P0.05), but combined blood therapy significantly decreased the anxiety score (P0.05). Safety indicators: in the treatment process, the two groups did not have adverse symptoms, blood, urine, feces and other three routine safety indicators and liver and kidney function and other safety indicators were not significantly abnormal (P0.05). Conclusion: for SS patients with anxiety, on the basis of using HCQ to treat the primary disease, adding Jinxueyuan granule can improve the dry symptoms and anxiety, and improve the laboratory indexes. No adverse reactions were found in the short-term application, and the safety was good.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259;R277.7
本文編號(hào)：2300230
[Abstract]:Objective: to evaluate the effect of Jinxueyuan granule combined with hydroxychloroquine sulfate (HCQ) tablets on patients with Sjogren's syndrome (SS) complicated with anxiety and to evaluate the improvement of dry symptoms and the changes of anxiety in patients with Sjogren's syndrome before and after treatment. Methods: from February 2015 to February 2016, 40 SS patients with anxiety were randomly divided into treatment group and control group, 20 cases in each group. The treatment group was treated with Jinxueyuan granule HCQ tablet orally, while the control group was treated with HCQ orally only, the observation period was 8 weeks. The symptoms and signs of the patients before and after treatment were evaluated by quantitative tables, and the changes of related laboratory indicators were analyzed. (HADa) and (SAS) were used to evaluate the anxiety of SS patients before and after treatment to compare the improvement of anxiety symptoms. The result is 1: 1. Comparison of general condition and disease condition before treatment: there was no significant difference in age, sex and course of disease between the two groups. There was no statistical difference in related laboratory indexes, TCM symptom and sign scores and anxiety scores (P0.05). The total effective rate of treatment group was 85 and that of control group was 550.The difference between the two groups was statistically significant (P0.05). The laboratory indexes (including erythrocyte sedimentation rate, C-reactive protein, immunoglobulin G) were significantly improved after treatment in both groups (P0.05), and the levels of ESR and CRP in the blood source treatment group were significantly lower than those in the control group (P0.05). In TCM symptom and sign score, the two groups were improved after treatment (P0.05). There was significant difference in the improvement of dry mouth and dry eye symptoms in the blood source treatment group. Improve the anxiety of patients: in the HCQ treatment group, the HADa score and SAS score decreased, but there was no statistical difference (P0.05), but combined blood therapy significantly decreased the anxiety score (P0.05). Safety indicators: in the treatment process, the two groups did not have adverse symptoms, blood, urine, feces and other three routine safety indicators and liver and kidney function and other safety indicators were not significantly abnormal (P0.05). Conclusion: for SS patients with anxiety, on the basis of using HCQ to treat the primary disease, adding Jinxueyuan granule can improve the dry symptoms and anxiety, and improve the laboratory indexes. No adverse reactions were found in the short-term application, and the safety was good.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R259;R277.7
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