【摘要】：目的：研究中醫(yī)五種治療模式對(duì)大腸癌患者癥狀改善作用的差異性。材料與方法：回顧性分析2015年3月至2016年3月于遼寧中醫(yī)藥大學(xué)附屬醫(yī)院腫瘤科住院治療的大腸癌患者的臨床資料,建立患者臨床資料數(shù)據(jù)庫(kù),根據(jù)納入標(biāo)準(zhǔn)及排除標(biāo)準(zhǔn)進(jìn)行篩選,最后有221例患者納入研究,并分為與西醫(yī)抗腫瘤治療結(jié)合的中醫(yī)鞏固組(無(wú)癌)、防護(hù)組(足量化療)、加載組(減量化療)、維持組(化療有效后,觀察)和單純中醫(yī)治療組。運(yùn)用SPSS 17.0統(tǒng)計(jì)軟件,采用配對(duì)t檢驗(yàn)和卡方檢驗(yàn),統(tǒng)計(jì)分析5組患者治療后的癥狀改善情況。結(jié)果：1、221例大腸癌患者經(jīng)過(guò)中醫(yī)藥治療后,乏力、氣短、大便異常(包括便秘、大便稀溏、便血)、疼痛、惡心嘔吐、食欲減退、失眠等癥狀積分均有顯著改善(P0.05)。其中,乏力癥狀經(jīng)治療后的改善率最高,為74.88%,其次為食欲減退,70.37%,便血癥狀的改善率最低,為28.57%,其他癥狀經(jīng)治療后的改善率在54%-64%之間。2、5組大腸癌患者的癥狀經(jīng)過(guò)治療后均有不同程度的改善,其癥狀平均積分與治療前相比較均明顯下降(P0.01);在癥狀治療有效率方面,中醫(yī)藥配合西醫(yī)抗腫瘤治療的兩組相比,防護(hù)組有效率明顯高于加載組(90.91%vs68.63%,P0.05);西醫(yī)抗腫瘤治療之后的兩組對(duì)比,鞏固組有效率明顯高于維持組(80.52%vs64.52%,P0.05);單純中醫(yī)治療組有效率為22%,明顯低于前4組(P0.05)。結(jié)論：1、中醫(yī)藥治療可以明顯改善大腸癌患者的臨床癥狀。2、中醫(yī)藥治療大腸癌的癥狀療效,與有無(wú)腫瘤及腫瘤進(jìn)展程度、有無(wú)化療及化療強(qiáng)度有關(guān),五種治療模式可以不同程度地提高與其相對(duì)應(yīng)的大腸癌患者的癥狀療效。
[Abstract]:Objective: to study the difference of symptom improvement in patients with colorectal cancer by five treatment modes of traditional Chinese medicine (TCM). Materials and methods: the clinical data of colorectal cancer patients hospitalized in Department of Oncology, affiliated Hospital of Liaoning University of traditional Chinese Medicine from March 2015 to March 2016 were analyzed retrospectively. According to the inclusion criteria and exclusion criteria, 221 patients were included in the study. They were divided into three groups: the Chinese medicine consolidation group (without cancer), the protective group (adequate chemotherapy), the loading group (reducing chemotherapy). Maintenance group (after chemotherapy, observation) and traditional Chinese medicine treatment group. Using SPSS 17.0 statistical software, paired t test and chi-square test were used to analyze the improvement of symptoms after treatment in 5 groups. Results: the scores of fatigue, shortness of breath, abnormal stool (including constipation, loose stool, bloody stool), pain, nausea and vomiting, loss of appetite and insomnia were significantly improved in 1221 patients with colorectal cancer after treatment with traditional Chinese medicine (P0.05). Among them, the improvement rate of symptoms of fatigue after treatment was the highest (74.88), followed by anorexia, 70.37, and the improvement rate of hematochezia was the lowest (28.57). The improvement rate of other symptoms after treatment was between 54% and 64%. After treatment, the symptoms of all the patients with colorectal cancer were improved to some extent, and the mean score of symptoms decreased significantly (P0.01). In terms of the effective rate of symptomatic treatment, the effective rate of the protection group was significantly higher than that of the loading group (90.91 vs 68.63 P 0.05). After anti-tumor therapy, the effective rate of consolidation group was significantly higher than that of maintenance group (80.52 vs 64.52, P0.05); the effective rate of traditional Chinese medicine treatment group was 22, significantly lower than that of the first four groups (P0.05). Conclusion: 1. Chinese medicine treatment can obviously improve the clinical symptoms of patients with colorectal cancer. 2. The effect of TCM treatment on the symptoms of colorectal cancer is related to the degree of tumor and tumor progression, the degree of chemotherapy and the intensity of chemotherapy. Five treatment modes can improve the symptomatic efficacy of colorectal cancer patients in varying degrees.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R273

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