發(fā)布時(shí)間：2018-10-26 12:59

【摘要】：目的:基于絡(luò)病理論組方苓澤合劑,觀察其治療濕熱瘀阻型急性痛風(fēng)性關(guān)節(jié)炎臨床療效。材料與方法:選取急性痛風(fēng)性關(guān)節(jié)炎(濕熱瘀阻證)患者共114例,按照隨機(jī)分組原則分為苓澤合劑組(治療組)57例和痛風(fēng)定膠囊組(對(duì)照組)57例,療程為7天,每周觀察記錄病情1次,隨訪28天后,比較兩組治療前后的中醫(yī)證候積分、疼痛評(píng)分、實(shí)驗(yàn)室指標(biāo)、臨床療效及安全情況,進(jìn)行觀察并分析總結(jié)。結(jié)果:1.中醫(yī)臨床療效治療組總有效率為92.85%,對(duì)照組總有效率為82.14%。治療組與對(duì)照組比較有統(tǒng)計(jì)學(xué)意義(P0.01)。2.治療組與對(duì)照組中醫(yī)證候積分、疼痛評(píng)分治療前組間比較無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);組內(nèi)治療前、后評(píng)分比較均有統(tǒng)計(jì)學(xué)意義(P0.01);治療后組間比較有統(tǒng)計(jì)學(xué)意義(P0.01)。3.治療組與對(duì)照組血沉、C反應(yīng)蛋白、血尿酸治療前組間比較無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);血沉、C反應(yīng)蛋白、血尿酸組內(nèi)治療前、后評(píng)分比較均有統(tǒng)計(jì)學(xué)意義(P0.01);血沉、C反應(yīng)蛋白治療后組間比較有統(tǒng)計(jì)學(xué)意義(P0.01),血尿酸治療后組間比較沒(méi)有統(tǒng)計(jì)學(xué)意義(P0.05)。4.治療組與對(duì)照組治療后患者對(duì)止痛療效判定比較差異有統(tǒng)計(jì)學(xué)意義(P0.01)。5.治療組與對(duì)照組谷丙轉(zhuǎn)氨酶、谷草轉(zhuǎn)氨酶、尿素氮、肌酐、甘油三酯、總膽固醇治療前組間比較無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);組內(nèi)治療前、后評(píng)分比較均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);治療后組間比較無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:1.苓澤合劑治療急性痛風(fēng)性關(guān)節(jié)炎(濕熱瘀阻型)有確切療效。2.苓澤合劑中醫(yī)癥候積分緩解程度優(yōu)于痛風(fēng)定膠囊。3.苓澤合劑緩解疼痛效果優(yōu)于痛風(fēng)定膠囊。4.苓澤合劑降低血沉、C反應(yīng)蛋白效果優(yōu)于痛風(fēng)定膠囊。5.苓澤合劑可降低血尿酸,與痛風(fēng)定膠囊無(wú)差異。6.短期應(yīng)用苓澤合劑治療痛風(fēng)性關(guān)節(jié)炎對(duì)肝、腎功能無(wú)損害。
[Abstract]:Objective: to observe the clinical effect of Lingze mixture in treating acute gouty arthritis of damp-heat stasis type based on collateral disease theory. Materials and methods: 114 patients with acute gouty arthritis (damp-heat stasis syndrome) were randomly divided into Lingze mixture group (treatment group) (57 cases) and gout ding capsule group (control group) 57 cases, the course of treatment was 7 days. The patients were observed and recorded once a week and followed up for 28 days. The scores of TCM syndromes, pain scores, laboratory indexes, clinical efficacy and safety were compared before and after treatment. The result is 1: 1. The total effective rate was 92.85 in the treatment group and 82.14 in the control group. Compared with the control group, the treatment group had statistical significance (P0.01). The scores of TCM syndromes and pain scores in the treatment group and the control group were not statistically significant (P0.05); the scores before and after treatment in the treatment group were statistically significant (P0.01). After treatment, there was significant difference between the two groups (P0.01). There was no significant difference in erythrocyte sedimentation rate, C-reactive protein and hematuria before treatment between the treatment group and the control group (P0.05), but the scores of ESR, C-reactive protein and hematuria acid group were statistically significant before and after treatment (P0.01). The erythrocyte sedimentation rate (ESR), C-reactive protein (C-reactive protein) after treatment was statistically significant (P0.01), but there was no statistical significance after hematuric acid treatment (P0.05). There was significant difference between the treatment group and the control group in the evaluation of analgesic effect (P0.01). There was no significant difference between treatment group and control group before treatment with alanine aminotransferase, urea nitrogen, creatinine, triglyceride and total cholesterol (P0.05). The scores before and after treatment were not statistically significant (P0.05); after treatment there was no statistical significance (P0.05). Conclusion: 1. Lingze mixture has definite curative effect on acute gouty arthritis (damp-heat stasis type). 2. Lingze mixture is better than Tongfengding capsule. 3. Lingze mixture is better than Tongfengding capsule in relieving pain. 4. Lingze mixture reduced erythrocyte sedimentation rate, C reactive protein effect was better than Tongfengding capsule. 5. Lingze mixture can reduce blood uric acid, and Tongfengding capsule no difference. 6. The short-term application of Lingze mixture in treating gouty arthritis has no damage to liver and kidney function.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R259

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