【摘要】：目的:觀察復元活血湯治療氣滯血瘀型椎動脈型頸椎病的臨床療效,并探討其作用機理,為臨床治療本病提供新的思路。方法:按入院先后順序將2014年10月至2016年3月于青州市人民醫(yī)院入院的患者采用隨機數(shù)字表法隨機分為治療組50例和對照組48例。治療組使用復元活血湯,對照組使用頸復康顆粒,30天為一療程。對病人進行用藥前后的量表評定及椎動脈血流速度檢測,兩組進行對比。結果:治療一個療程后,治療組總有效率96%優(yōu)于對照組總有效率88%。治療后兩組頸椎功能障礙指數(shù)較治療前均明顯降低,P0.001,且治療組(3.32±2.66)較對照組(4.74±3.48)降低明顯,P=0.024;治療后兩組視覺模擬評分較治療前均明顯減小,P0.001,而治療組視覺模擬評分(1.94±1.30)較對照組(2.54±1.15)減小更為明顯,P=0.016;治療后兩組椎動脈血流速度(雙側收縮期血流速度、舒張末期血流速度)較治療前均明顯增快,P0.001,治療后治療組左椎動脈收縮期血流速度(43.30±9.58)、舒張末期血流速度(25.30±4.78),右椎動脈收縮期血流速度(41.80±9.40)、舒張末期血流速度(24.82±5.86)分別較對照組左椎動脈收縮期血流速度(38.56±6.23);舒張末期血流速度(22.52±6.28);右椎動脈收縮期血流速度(37.66±9.92);舒張末期血流速度(22.28±6.56)改善明顯(P=0.004;0.014;0.035;0.033)。結論:復元活血湯用于治療氣滯血瘀型椎動脈型頸椎病療效優(yōu)于頸復康顆粒。其作用機制可能與以下因素有關:增快椎動脈血流速度,改善椎動脈血流狀態(tài),促進受損神經(jīng)組織的恢復。
[Abstract]:Objective: to observe the clinical effect of Fuyuan Huoxue decoction in treating cervical spondylosis of vertebral artery type of Qi stagnation and blood stasis type, and to explore its mechanism, and to provide a new idea for clinical treatment of this disease. Methods: patients admitted to Qingzhou people's Hospital from October 2014 to March 2016 were randomly divided into treatment group (n = 50) and control group (n = 48). The treatment group was treated with Fuyuan Huoxue decoction and the control group with Jingfukang granule for 30 days. The patients were assessed with the scale before and after treatment and the blood flow velocity of vertebral artery was measured, and the two groups were compared. Results: after a course of treatment, the total effective rate of the treatment group was 96% better than that of the control group. After treatment, the cervical spine dysfunction index in both groups was significantly lower than that before treatment (P 0.001), and in the treatment group (3.32 鹵2.66) was significantly lower than that in the control group (4.74 鹵3.48), the visual analogue score in the two groups was significantly lower than that before treatment (P 0.001), and the visual analogue score in the treatment group (1.94 鹵1.30) was significantly lower than that in the control group (4.74 鹵3.48). Compared with the control group (2.54 鹵1.15), the blood flow velocity of vertebral artery decreased significantly (P < 0.016). After treatment, left vertebral artery systolic velocity (43.30 鹵9.58), end-diastolic blood flow velocity (25.30 鹵4.78), right vertebral artery systolic flow velocity (41.80 鹵9.40) and end-diastolic blood flow velocity (24.82 鹵5.86) were significantly faster than those before treatment. In the control group, left vertebral artery systolic velocity (38.56 鹵6.23), end-diastolic flow velocity (22.52 鹵6.28), right vertebral artery systolic velocity (37.66 鹵9.92) and end-diastolic flow velocity (22.28 鹵6.56) were significantly improved (P < 0.004). Conclusion: Fuyuan Huoxue decoction is superior to Zhifukang granule in treating cervical spondylosis of vertebral artery type of Qi stagnation and blood stasis. The mechanism may be related to the following factors: increasing the blood flow velocity of the vertebral artery, improving the blood flow status of the vertebral artery, and promoting the recovery of injured nerve tissue.
【學位授予單位】：青島大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R274.9
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本文編號：2292142