【摘要】：目的:本研究主要觀察了柴胡疏肝散加減治療肝郁氣滯型經(jīng)前期綜合征的臨床療效,并對此法進行療效評估。為本法在臨床上應(yīng)用及推廣提供依據(jù)。研究方法:本研究納入了 64例肝郁氣滯型經(jīng)前綜合征的患者,隨機分為治療組與對照組,每組32例。治療組口服柴胡疏肝散的方法進行治療,對照組口服鹽酸氟西汀片。共治療3個月經(jīng)周期。觀察兩組患者治療后各癥狀積分及相關(guān)療效指標的改善情況。結(jié)果:1.臨床療效分析:治療組總好轉(zhuǎn)率為80%,對照組總好轉(zhuǎn)率為74.2%,兩組相比P0.05,無顯著性差異,說明柴胡疏肝散和鹽酸氟西汀片均可以改善PMS的癥狀。2.中醫(yī)證候分析:兩組患者中醫(yī)證候療效的比較,治療組總有效率為90%,對照組總有效率為67.7%,P0.05,有顯著性差異,說明在改善中醫(yī)證候方面,柴胡疏肝散優(yōu)于鹽酸氟西汀片。3.內(nèi)分泌孕酮(P)分析:治療后兩組的孕酮比較(P0.05),差異無統(tǒng)計學意義。兩組治療前后孕酮比較(P0.05),無顯著性差異,說明兩組治療方法對患者的孕酮水平幾乎沒有影響。4.遠期療效分析:兩組患者在治療結(jié)束后3個月進行療效評估,其中治療組總有效率為76.7%,對照組總有效率為45.2%,P0.05,有顯著性差異,說明在治療肝郁氣滯型經(jīng)前期綜合征的遠期療效上柴胡疏肝散明顯優(yōu)于鹽酸氟西汀片。結(jié)論:1.柴胡疏肝散加減能夠有效的改善肝郁氣滯型經(jīng)前期綜合征的癥狀,其總好轉(zhuǎn)率為80%。2.柴胡疏肝散加減對改善肝郁氣滯型經(jīng)前期綜合征的中醫(yī)證候良好的成效,其總有效率為90%,優(yōu)于鹽酸氟西汀片。3.柴胡疏肝散加減不僅能有效改善肝郁氣滯型經(jīng)前期綜合征的各癥狀體征,而且其遠期療效明顯的優(yōu)于西藥。在用藥期間,柴胡疏肝散未出現(xiàn)明顯的副作用,可以作為治療經(jīng)前期綜合征的一種安全有效方法,值得在臨床實踐及科學研究上推廣應(yīng)用。
[Abstract]:Objective: to observe the clinical effect of Chaihu Shugan Powder in treating premenstrual syndrome of stagnation of liver qi. To provide the basis for the clinical application and popularization of this method. Methods: 64 patients with premenstrual syndrome of stagnation of liver-qi were randomly divided into treatment group and control group with 32 cases in each group. The treatment group was treated with Chaihu Shugan Powder and the control group with fluoxetine hydrochloride tablets. A total of 3 menstrual cycles were treated. To observe the improvement of symptom score and related curative effect index after treatment in the two groups. The result is 1: 1. Clinical efficacy analysis: the total improvement rate of treatment group was 80 and that of control group was 74.2. There was no significant difference between the two groups compared with P0.05, indicating that both Chaihu Shugan San and fluoxetine hydrochloride tablets could improve the symptoms of PMS. 2. Analysis of TCM syndromes: the total effective rate of treatment group was 90, the total effective rate of control group was 67.7% (P0.05), which indicated that Chaihu Shugan Powder was superior to fluoxetine Hydrochloride tablet in improving TCM syndromes. Endocrine progesterone (P) analysis: after the treatment of progesterone comparison between the two groups (P0.05), the difference was not statistically significant. There was no significant difference in progesterone levels between the two groups before and after treatment (P0.05), indicating that there was almost no effect on progesterone level in the two groups. Long-term curative effect analysis: the two groups were evaluated at 3 months after the end of treatment. The total effective rate of the treatment group was 76.7, the total effective rate of the control group was 45.2% (P 0.05), there was significant difference between the two groups. It indicated that the long-term curative effect of chaihu Shugan San was better than fluoxetine hydrochloride tablet in the treatment of premenstrual syndrome with stagnation of liver and qi. Conclusion: 1. The addition and subtraction of Chaihu Shugan San can effectively improve the symptoms of premenstrual syndrome of liver depression and qi stagnation type, and its total improvement rate is 80.2. The addition and subtraction of Chaihu Shugan San has good effect on improving the syndrome of premenstrual syndrome of liver depression and qi stagnation type. Its total effective rate is 90, which is better than fluoxetine hydrochloride tablet. The addition and subtraction of Chaihu Shugan San can not only effectively improve the symptoms and signs of premenstrual syndrome of liver depression and qi stagnation, but also have a better long-term effect than western medicine. During the period of medication, Chaihu Shugan Powder has no obvious side effects, which can be regarded as a safe and effective method for the treatment of premenstrual syndrome. It is worth popularizing and applying in clinical practice and scientific research.
【學位授予單位】：黑龍江中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R271.115

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