補(bǔ)腎祛濕法治療復(fù)發(fā)性生殖器皰疹對血清Th17細(xì)胞和IL-17表達(dá)水平的影響
發(fā)布時(shí)間：2018-10-15 14:18
【摘要】：目的觀察補(bǔ)腎祛濕中藥治療復(fù)發(fā)性生殖器皰疹(RGH)的臨床療效,探討Th17細(xì)胞、白細(xì)胞介素(IL)-17在RGH發(fā)病中的作用。方法將60例RGH患者用隨機(jī)數(shù)字表法分為補(bǔ)腎祛濕組及阿昔洛韋組各30例,另選擇健康對照者30例(健康對照組),補(bǔ)腎祛濕組給予補(bǔ)腎祛濕中藥湯劑(補(bǔ)腎祛濕中藥復(fù)方組成:鹽牛膝10 g,黃柏15 g,黃芪30 g,當(dāng)歸20 g,蒼術(shù)20 g,土茯苓20 g,板藍(lán)根30 g,大青葉10 g,馬齒莧30 g,柴胡6 g,粉葛30g,蜂房10 g,甘草6 g),阿昔洛韋組給予阿昔洛韋口服,療程均為6個(gè)月;用流式細(xì)胞儀檢測RGH患者及健康對照組外周血中Th17細(xì)胞的比例,ELISA法檢測外周血血清IL-17水平。結(jié)果治療后補(bǔ)腎祛濕組臨床癥狀評分顯著低于阿昔洛韋組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);補(bǔ)腎祛濕組愈顯率高于阿昔洛韋組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);兩組RGH患者治療前外周血中Th17細(xì)胞比例及IL-17水平均明顯高于健康對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);兩組RGH患者經(jīng)治療后Th17細(xì)胞比例及IL-17水平均下降,補(bǔ)腎祛濕組下降程度顯著大于阿昔洛韋組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論補(bǔ)腎祛濕法治療RGH可顯著改善患者臨床癥狀和體征,提高臨床療效,降低血清Th17細(xì)胞比例及IL-17水平。Th17細(xì)胞及IL-17可能參與了RGH的發(fā)病過程。
[Abstract]:Objective to observe the clinical effect of tonifying the kidney and removing dampness in the treatment of recurrent genital herpes (RGH), and to explore the role of Th17 cells and interleukin (IL) 17 in the pathogenesis of RGH. Methods 60 patients with RGH were randomly divided into two groups: the group of tonifying kidney and dispelling dampness and the group of acyclovir (n = 30). Another 30 healthy controls (healthy control group) were selected. The group of tonifying kidney and dispelling dampness was given traditional Chinese medicine decoction of tonifying kidney and removing dampness. Radix Isatidis 30 g, Isatidis root 10 g, Portulaca oleracea 30 g, Bupleurum 6 g, Pueraria lobata 30 g, honeycomb 10 g, Glycyrrhiza 6 g), acyclovir orally. Flow cytometry was used to detect the proportion of Th17 cells in peripheral blood of patients with RGH and healthy controls, and ELISA method was used to detect the level of IL-17 in peripheral blood. Results after treatment, the clinical symptom score of tonifying kidney and removing dampness group was significantly lower than that of acyclovir group, the difference was statistically significant (P0.05), and the effective rate of healing in tonifying kidney dispelling dampness group was higher than that in acyclovir group. The proportion of Th17 cells and IL-17 level in peripheral blood of RGH patients before treatment were significantly higher than those in healthy control group (P0.05). The proportion of Th17 cells and IL-17 level in RGH patients of two groups decreased after treatment. The decreasing degree of tonifying kidney and removing dampness group was significantly higher than that of acyclovir group, the difference was statistically significant (P0.05). Conclusion the method of tonifying the kidney and removing dampness can significantly improve the clinical symptoms and signs, increase the clinical efficacy, decrease the proportion of serum Th17 cells and the level of IL-17. Th17 cells and IL-17 may be involved in the pathogenesis of RGH.
【作者單位】： 廣州醫(yī)科大學(xué)附屬第三醫(yī)院皮膚科;廣州中醫(yī)藥大學(xué)第一附屬醫(yī)院檢驗(yàn)科;廣州中醫(yī)藥大學(xué)第一附屬醫(yī)院皮膚科;廣州中醫(yī)藥大學(xué)第三附屬醫(yī)院皮膚科;
【基金】：廣東省中醫(yī)藥局建設(shè)中醫(yī)藥強(qiáng)省科研課題(編號:20141083)
【分類號】：R275.9
[Abstract]:Objective to observe the clinical effect of tonifying the kidney and removing dampness in the treatment of recurrent genital herpes (RGH), and to explore the role of Th17 cells and interleukin (IL) 17 in the pathogenesis of RGH. Methods 60 patients with RGH were randomly divided into two groups: the group of tonifying kidney and dispelling dampness and the group of acyclovir (n = 30). Another 30 healthy controls (healthy control group) were selected. The group of tonifying kidney and dispelling dampness was given traditional Chinese medicine decoction of tonifying kidney and removing dampness. Radix Isatidis 30 g, Isatidis root 10 g, Portulaca oleracea 30 g, Bupleurum 6 g, Pueraria lobata 30 g, honeycomb 10 g, Glycyrrhiza 6 g), acyclovir orally. Flow cytometry was used to detect the proportion of Th17 cells in peripheral blood of patients with RGH and healthy controls, and ELISA method was used to detect the level of IL-17 in peripheral blood. Results after treatment, the clinical symptom score of tonifying kidney and removing dampness group was significantly lower than that of acyclovir group, the difference was statistically significant (P0.05), and the effective rate of healing in tonifying kidney dispelling dampness group was higher than that in acyclovir group. The proportion of Th17 cells and IL-17 level in peripheral blood of RGH patients before treatment were significantly higher than those in healthy control group (P0.05). The proportion of Th17 cells and IL-17 level in RGH patients of two groups decreased after treatment. The decreasing degree of tonifying kidney and removing dampness group was significantly higher than that of acyclovir group, the difference was statistically significant (P0.05). Conclusion the method of tonifying the kidney and removing dampness can significantly improve the clinical symptoms and signs, increase the clinical efficacy, decrease the proportion of serum Th17 cells and the level of IL-17. Th17 cells and IL-17 may be involved in the pathogenesis of RGH.
【作者單位】： 廣州醫(yī)科大學(xué)附屬第三醫(yī)院皮膚科;廣州中醫(yī)藥大學(xué)第一附屬醫(yī)院檢驗(yàn)科;廣州中醫(yī)藥大學(xué)第一附屬醫(yī)院皮膚科;廣州中醫(yī)藥大學(xué)第三附屬醫(yī)院皮膚科;
【基金】：廣東省中醫(yī)藥局建設(shè)中醫(yī)藥強(qiáng)省科研課題(編號:20141083)
【分類號】：R275.9
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