【摘要】：目的探究咽部刺營療法治療慢性咽炎的臨床效果。觀察咽部刺營法對慢性咽炎模型動物的咽部病理形態(tài)學(xué)影響。方法1臨床研究將120例慢性咽炎患者按1:1比例隨機(jī)分為咽部刺營觀察組和西藥對照組。觀察組采用咽部刺營療法治療;對照組采用頭孢地尼膠囊口服。兩組均治療2個(gè)療程,觀察兩組的治療效果并做統(tǒng)計(jì)學(xué)處理。對參加試驗(yàn)的所有病例,在治療前后檢測血清白細(xì)胞介素-2(IL-2)、腫瘤壞死因子-α(TNF-α)水平,觀察其變化并做統(tǒng)計(jì)學(xué)處理。2實(shí)驗(yàn)研究將50只新西蘭兔隨機(jī)分為5組,每組10只:A組為咽部刺營療法組,B組為單純模型組,C組為利咽合劑治療組,D組為空白對照組,E組為自然恢復(fù)組。A、B、C、E組動物均建立慢性咽炎模型。造模完成后,處死單純模型組動物;A組動物行咽部刺營治療,C組動物以利咽合劑給藥治療,D組動物以蒸餾水局部噴霧為對照,E組動物不予治療。各組動物處死后,立即取下咽部黏膜組織切片觀察。結(jié)果1臨床研究結(jié)果(1)選取的觀察組、治療組患者的性別、年齡及病程長短無統(tǒng)計(jì)學(xué)差異。(2)治療2個(gè)療程后,觀察組治愈33例,顯效22例,無效5例,總有效率91.67%;對照組治愈20例,顯效21例,無效19例,總有效率68.33%。觀察組治療后的有效率明顯高于西藥對照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。(3)觀察組、對照組的各項(xiàng)癥狀體征均較治療前顯著改善,而觀察組在改善癥狀體征方面更優(yōu)于對照組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。(4)治療后兩組血清IL-2、TNF-α均較治療前顯著改善,且對照組的改善程度不及觀察組,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。2實(shí)驗(yàn)研究結(jié)果(1)咽部刺營療法組的模型動物經(jīng)過治療后,飲食、飲水均較治療前增多,活動量逐漸增多,精神狀態(tài)也較前好轉(zhuǎn)。(2)病理形態(tài)學(xué)觀察結(jié)果顯示,慢性咽炎的模型動物通過咽部刺營療法治療后,有3只兔咽部黏膜病理形態(tài)恢復(fù)正常,7只兔有輕度炎癥、水腫或充血。結(jié)論(1)臨床研究結(jié)論臨床觀察顯示,咽部刺營療法能明顯改善慢性咽炎患者臨床癥狀;咽部刺營療法在臨床應(yīng)用過程中安全有效、無毒副作用。(2)實(shí)驗(yàn)研究結(jié)論動物實(shí)驗(yàn)研究表明,咽部刺營法可有效改善咽部炎性細(xì)胞浸潤,減輕血管充血,緩解黏膜腫脹。
[Abstract]:Objective to explore the clinical effect of treating chronic pharyngitis with pharynx acupuncture-ying therapy. To observe the pathomorphology of pharynx of chronic pharyngitis model animal treated with pharynx needling-ying method. Methods 1 120 patients with chronic pharyngitis were randomly divided into the observation group and the control group at 1:1. The observation group was treated with pharyngeal needling and the control group was treated with cefdinil capsule. The two groups were treated for 2 courses. The therapeutic effects of the two groups were observed and statistically analyzed. The serum levels of interleukin-2 (IL-2) and tumor necrosis factor- 偽 (TNF- 偽) were measured before and after treatment. There were 10 rats in each group: group A was treated with pharynx needling, group B was simple model group, group C was treated with Liyan mixture, group D was blank control group, group E was natural recovery group. After the model was made, the simple model group was killed, the animals in group A were treated with pharynx needling, the animals in group C were treated with Liyan mixture, the animals in group D were treated by local spray of distilled water, and the animals in group E were not treated. After the animals were killed, the mucosal sections of hypopharynx were taken and observed immediately. Results (1) there was no significant difference in sex, age and course of disease between the two groups. (2) after two courses of treatment, 33 cases were cured, 22 cases were markedly effective, 5 cases were ineffective in the observation group. The total effective rate was 91.67. In the control group, 20 cases were cured, 21 cases were markedly effective, 19 cases were ineffective, and the total effective rate was 68.33. The effective rate after treatment in the observation group was significantly higher than that in the western medicine control group, the difference was statistically significant (P0.05). (3). The symptoms and signs of the control group were significantly improved than those of the control group, and the observation group was better than the control group in improving the symptoms and signs. The difference was statistically significant (P0.05). (4) after treatment, the serum IL-2,TNF- 偽 of the two groups were significantly improved compared with those of the control group, and the improvement degree of the control group was not as good as that of the observation group. The difference was statistically significant (P0.05). 2 results (1) after treatment, the diet and drinking water of the model animals in the pharynx needling group increased, and the activity increased gradually. (2) the results of pathomorphological observation showed that after the treatment of chronic pharyngitis, 3 rabbits had normal morphology of pharyngeal mucosa, 7 rabbits had mild inflammation, edema or hyperemia. Conclusion (1) Clinical observation shows that pharynx needling therapy can obviously improve the clinical symptoms of patients with chronic pharyngitis, and it is safe and effective in clinical application. (2) No toxic side effects. (2) the animal experimental study showed that pharynx needling can effectively improve the infiltration of inflammatory cells in the pharynx, reduce blood vessel congestion, and alleviate mucosal swelling.
【學(xué)位授予單位】：湖北中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R276.1

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