【摘要】：目的:觀察健脾溫腎湯在維持治療緩解期潰瘍性結(jié)腸炎(脾腎陽(yáng)虛證)的臨床療效及安全性;比較健脾溫腎湯與美沙拉嗪腸溶片在治療緩解期潰瘍性結(jié)腸炎過(guò)程中的復(fù)發(fā)率。方法:選取2015年1月至2015年7月就診于安陽(yáng)市中醫(yī)院肝膽脾胃科門(mén)診符合納入標(biāo)準(zhǔn)、排除標(biāo)準(zhǔn)的受試者68例,隨機(jī)分為實(shí)驗(yàn)組34例與照組34例。實(shí)驗(yàn)組給予健脾溫腎湯,對(duì)照組給予美沙拉嗪腸溶片治療,療程為12周。詳細(xì)記錄受試者治療過(guò)程中的癥狀變化及復(fù)發(fā)率。療程結(jié)束后受試者來(lái)院復(fù)查,并將所收集的數(shù)據(jù)資料統(tǒng)計(jì)匯總,建立數(shù)據(jù)庫(kù),用SPSS18.0軟件進(jìn)行統(tǒng)計(jì)、分析,記錄統(tǒng)計(jì)結(jié)果。結(jié)果:1.綜合療效比較,實(shí)驗(yàn)組綜合療效有效率93.76%,對(duì)照組綜合療效有效率87.88%,實(shí)驗(yàn)組與對(duì)照組綜合療效比較,P0.05,具有明顯差異。2.中醫(yī)癥候療效比較,實(shí)驗(yàn)組中醫(yī)癥候療效有效率96.86%,對(duì)照組中醫(yī)癥候療效有效率63.64%,組內(nèi)比較,實(shí)驗(yàn)組治療前與治療后各癥候比較,P0.05,具有明顯差異;對(duì)照組治療前與治療后各癥候比較,P0.05,具有明顯差異。組間比較,實(shí)驗(yàn)組治療后與對(duì)照組治療后各癥候比較,P0.05,具有明顯差異。3.實(shí)驗(yàn)組治療后結(jié)腸黏膜有效率93.75%,對(duì)照組治療后結(jié)腸黏膜有效率為54.55%,實(shí)驗(yàn)組與對(duì)照組黏膜有效率比較,P0.05,具有明顯差異。4.實(shí)驗(yàn)組治療過(guò)程中復(fù)發(fā)率3.13%,對(duì)照組治療過(guò)程中復(fù)發(fā)率為21.21%,實(shí)驗(yàn)組與對(duì)照組復(fù)發(fā)率比較,P0.05,具有明顯差異。5.實(shí)驗(yàn)組治療過(guò)程中無(wú)受試者發(fā)生不良反應(yīng),對(duì)照組治療過(guò)程中不良反應(yīng)發(fā)生率為15.15%,實(shí)驗(yàn)組與對(duì)照組不良反應(yīng)發(fā)生率比較,P0.05,具有明顯差異。結(jié)論:1.健脾溫腎湯能明顯改善緩解期脾潰瘍性結(jié)腸炎(脾腎陽(yáng)虛證)患者的腹瀉、腹痛、腹脹、里急后重、便血、形寒肢冷、腰膝酸軟等癥狀,能促進(jìn)腸黏膜愈合,且較美沙拉嗪腸溶片有明顯優(yōu)勢(shì)。2.健脾溫腎湯治療緩解期潰瘍性結(jié)腸炎(脾腎陽(yáng)虛證)患者的復(fù)發(fā)率較美沙拉嗪腸溶片低,不良反應(yīng)少,可做為維持治療緩解期潰瘍性結(jié)腸炎(脾腎陽(yáng)虛證)安全有效的藥物。
[Abstract]:Objective: to observe the clinical efficacy and safety of Jianpi Wenshen decoction (Jianpi Wenshen decoction) in the treatment of remission ulcerative colitis (spleen and kidney yang deficiency syndrome), and to compare the recurrence rate of Jianpi Wenshen decoction and mesalazine enteric coated tablets in the treatment of remission ulcerative colitis. Methods: from January 2015 to July 2015, 68 subjects who met the inclusion criteria and excluded criteria were randomly divided into experimental group (n = 34) and radiation group (n = 34). The experimental group was treated with Jianpi Wenshen decoction, the control group was treated with mesalazine enteric-coated tablets for 12 weeks. The changes of symptoms and recurrence rate during treatment were recorded in detail. At the end of the course, the subjects came to the hospital to review and collect the collected data, set up the database, and use SPSS18.0 software to make statistics, analysis and record the statistical results. The result is 1: 1. The comprehensive effective rate of experimental group was 93.76%, that of control group was 87.88%, and that of experimental group was significantly higher than that of control group (P 0.05). The effective rate of TCM syndromes was 96.866.86 in the experimental group and 63.64in the control group. There was significant difference between the experimental group before treatment and after treatment (P0.05). The symptoms of the control group were significantly different before and after treatment (P 0.05). Comparison between groups, the experimental group after treatment and control group after the treatment of symptoms, P0.05, with significant difference. The effective rate of colonic mucosa in the experimental group was 93.75 and that in the control group was 54.55.The effective rate of the experimental group was significantly higher than that of the control group (P 0.05). The relapse rate was 3.13 in the experimental group and 21.21 in the control group. The recurrence rate in the experimental group was significantly different from that in the control group (P 0.05). There were no adverse reactions in the experimental group and 15.15 in the control group. There was a significant difference between the experimental group and the control group in the incidence of adverse reactions (P0.05). Conclusion: 1. Jianpi Wenshen decoction can obviously improve the diarrhea, abdominal pain, abdominal distension, blood stool, cold limbs, sore waist and knee in patients with splenic ulcerative colitis (spleen and kidney yang deficiency syndrome) in remission period, and can promote the healing of intestinal mucosa. Compared with mesalazine enteric coated tablets, it has obvious advantage. 2. The relapse rate of Jianpi Wenshen decoction in the treatment of ulcerative colitis (spleen and kidney yang deficiency syndrome) is lower than that of mesalazine enteric coated tablets, and it can be used as a safe and effective drug for the treatment of ulcerative colitis (spleen and kidney yang deficiency syndrome) in remission period.
【學(xué)位授予單位】：河南中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R259

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