【摘要】：目的:運(yùn)用關(guān)聯(lián)規(guī)則對(duì)明代治療頭痛方劑進(jìn)行挖掘分析,總結(jié)明代治療頭痛方劑中的主要藥物,并分析藥物之間的組方配伍規(guī)律特點(diǎn),為現(xiàn)代臨床頭痛的中醫(yī)藥治療提供借鑒。方法:以《中醫(yī)方劑大辭典》中的方劑為數(shù)據(jù)來(lái)源建立相關(guān)數(shù)據(jù)庫(kù),并提取其中有關(guān)明代治療頭痛的內(nèi)服方劑作為數(shù)據(jù)集,選用SPSS Clementine12.0軟件對(duì)所建數(shù)據(jù)集中的藥物組成進(jìn)行挖掘,運(yùn)用Apriori算法建立相關(guān)數(shù)據(jù)挖掘模型,設(shè)置最大前項(xiàng)數(shù)為5,最小支持度8%,最小置信度70%,并對(duì)藥物之間的配伍組合以Web節(jié)點(diǎn)形式進(jìn)行圖形化展示。結(jié)果:獲得符合標(biāo)準(zhǔn)的明代治療頭痛的內(nèi)服方劑共計(jì)115首,涉及藥物達(dá)153種,藥物的使用總頻次為951次。在所包含的全部藥物中,使用超過(guò)10次的藥物達(dá)到32味,其使用頻次共計(jì)684次,占藥物總頻次的71.92%。其中在方劑所含藥物中,使用頻次最高的藥類為解表藥,共計(jì)300次,占各類藥物使用總頻次的31.55%,其后依次為補(bǔ)虛藥、清熱藥、活血化瘀藥、化痰藥、理氣藥、利水滲濕藥、祛風(fēng)濕藥、平肝息風(fēng)藥及化濕藥等,這些藥類的使用頻次達(dá)816次,共占藥物總使用頻次的85.80%。通過(guò)關(guān)聯(lián)規(guī)則分析得到符合條件規(guī)則共計(jì)336條,其中4味藥組合的規(guī)則數(shù)最多,共產(chǎn)生148條,其次為3味藥組合的規(guī)則,共獲得125條。在所有獲得規(guī)則中出現(xiàn)頻次最多的藥物是川芎,其中含川芎的前項(xiàng)規(guī)則數(shù)為110條,后項(xiàng)規(guī)則數(shù)為83條,共計(jì)193條。在全部符合條件的規(guī)則中,擁有較高置信度及支持度的規(guī)則有:蔓荊子→川芎、細(xì)辛→川芎、白芷→川芎、藁本→川芎、升麻→甘草、藁本+細(xì)辛→川芎、蔓荊子+細(xì)辛→川芎、荊芥+茶→川芎、荊芥+羌活→白芷、茶+白芷→川芎、防風(fēng)+細(xì)辛→川芎、白芷+細(xì)辛→川芎、白芷+甘草→川芎、細(xì)辛+甘草→川芎、防風(fēng)+白芷→川芎、羌活+細(xì)辛→川芎、荊芥+白芷→川芎、羌活+細(xì)辛+甘草→川芎、羌活+防風(fēng)+細(xì)辛→川芎、羌活+白芷+細(xì)辛→川芎、荊芥+羌活+白芷→川芎、白芷+細(xì)辛+甘草→川芎、羌活+防風(fēng)+甘草→川芎等。結(jié)論:明代治療頭痛的常用藥物為風(fēng)藥,其中川芎是明代治療頭痛的第一要藥,且川芎與解表藥的配伍組合在明代治療頭痛的方劑中最為常見;補(bǔ)虛藥與清熱藥是明代頭痛的常用藥類,且與風(fēng)藥之間具有較豐富的配伍;關(guān)聯(lián)規(guī)則可用于挖掘古代頭痛方劑中藥物間的配伍規(guī)律研究。
[Abstract]:Objective: to explore and analyze the prescriptions for treating headache in Ming Dynasty by using association rules, summarize the main drugs in the prescriptions of treating headache in Ming Dynasty, and analyze the characteristics of prescription compatibility among them, so as to provide reference for the treatment of headache in modern clinic. Methods: the relevant database was established with the prescriptions in the Big Dictionary of traditional Chinese Medicine as the data source, and the internal prescriptions for treating headache in Ming Dynasty were extracted as data sets. The composition of drugs in the data set was mined by SPSS Clementine12.0 software. The Apriori algorithm is used to set up the data mining model. The maximum number of front terms is 5, the minimum support is 8, and the minimum confidence is 70. The compatibility between drugs is displayed graphically in the form of Web nodes. Results: 115 prescriptions for headache in Ming Dynasty were obtained, 153 kinds of drugs were involved, and the total frequency of drug use was 951 times. Of all the drugs involved, 32 were used more than 10 times, and the total frequency was 684, accounting for 71.92% of the total drug frequency. Among the drugs contained in the prescription, the most frequently used drugs were antitabular drugs (300 times in total), accounting for 31.55 times of the total frequency of use of various kinds of drugs, followed by tonifying drugs, clearing away heat drugs, promoting blood circulation and removing stasis drugs, resolving phlegm drugs, regulating qi drugs, promoting water and infiltrating dampness drugs. The use frequency of these drugs was 816 times, which accounted for 85.80 times of the total use frequency. A total of 336 matching rules were obtained by analyzing association rules, of which the number of four kinds of drugs was the most, and 148 rules were produced, followed by the rules of 3 kinds of drugs, with a total of 125. The most frequent drug in all the rules is Chuanxiong, in which there are 110 rules for the former item and 193 rules for the latter item. Among all the eligible rules, the rules with higher confidence and support are: Ligusticum chinensis, Ligusticum Asarum, Radix angelicae dahurica, Ligusticum ligustii, Radix Glycyrrhiza and Ligustragopsis sinensis, Ligusticum chuanxiong, Chuanxiong, Liangshen, Chuanxiong, Chuanxiong of Radix angelicae dahurica, Ligusticum chuanxiong of Radix Notopterygiae, Ligusticum dahurica, Ligusticum sinensis of Radix angelicae dahurica, Ligusticum chuanxiong of Radix angelicae Sinensis, Rhizoma Notopterygii, Radix angelicae dahuricae Ligusticum, Radix angelicae dahurica Ligusticum Radix angelicae dahurica liquorice Ligusticum, Radix Notopterygii Fangfeng liquorice Ligusticum chuanxiong and so on. Conclusion: the common medicine for treating headache in Ming Dynasty is wind medicine. Chuanxiong is the first important drug in treating headache in Ming Dynasty, and the combination of Ligusticum chuanxiong and antitabular medicine is the most common prescription in the treatment of headache in Ming Dynasty. Tonifying deficiency medicine and heat-clearing medicine are common drugs for headache in Ming Dynasty, and there is a rich compatibility with wind medicine, and association rules can be used to study the compatibility law between drugs in ancient headache prescriptions.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R277.7

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