【摘要】：目的觀察補(bǔ)腎調(diào)肝方對非肥胖型多囊卵巢綜合征(polycystic ovary syndrome,PCOS)糖脂代謝的影響。方法將60例腎虛肝郁型非肥胖型PCOS(BMI25)患者,隨機(jī)分為治療組和對照組,每組30例。治療組采用補(bǔ)腎調(diào)肝方(毓麟珠合柴胡舒肝散)每日1劑,早晚分服;對照組選用二甲雙胍片(1 000 mg/次),每日2次,早晚隨餐口服;兩組療程均為3個(gè)月。觀察治療前后空腹血糖(fasting plasma glucose,FPG)、空腹胰島素(fasting insulin,FINS),穩(wěn)態(tài)胰島素抵抗指數(shù)(homeostasis model assessment-insulin resistance,HOMA-IR)、TC、TG、體重指數(shù)(body mass index,BMI)、腰臀比(waist hip ratio,WHR)、黃體生成素(luteinizing hormone,LH)、卵泡雌激素(follicle stimulating hormone,FSH)、LH/FSH以及游離睪酮(free testosterone,T)水平變化。結(jié)果與本組治療前比較,對照組FPG、FINS、LH/FSH及BMI下降(P0.05,P0.01),治療組FPG、TC、LH、LH/FSH、WHR及BMI均下降(P0.05,P0.01)。與對照組比較,治療組WHR、BMI、FINS、LH水平差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論非肥胖型PCOS患者不以全身胰島素抵抗為主要表現(xiàn);補(bǔ)腎調(diào)肝方通過降低LH、LH/FSH,改善糖脂代謝情況,從而對非肥胖型PCOS起到治療作用。
[Abstract]:Objective to observe the effect of Bushen Tiaogan recipe on glucose and lipid metabolism in non-obese polycystic ovary syndrome (polycystic ovary syndrome,PCOS). Methods 60 cases of non-obese PCOS (BMI25) with kidney deficiency and liver depression were randomly divided into treatment group and control group with 30 cases in each group. The treatment group was treated with Bushen Tiaogan decoction (Yulin Zhuhe and Chaihu Shugan Powder), and the control group was treated with metformin tablet (1 000 mg/) twice a day, with meal in the morning and evening. The course of treatment in both groups was 3 months. Fasting plasma glucose (fasting plasma glucose,FPG), fasting insulin (fasting insulin,FINS), steady-state insulin resistance index (homeostasis model assessment-insulin resistance,HOMA-IR), body mass index (body mass index,BMI), waist to hip ratio (waist hip ratio,WHR), luteinizing hormone (luteinizing hormone,LH), follicular estrogen (follicle stimulating hormone,FSH (follicle stimulating hormone,FSH) and free testosterone (free testosterone,T) were observed before and after treatment. Results compared with before treatment, FPG,FINS,LH/FSH and BMI in control group were decreased (P0.05, P0.01), FPG,TC,LH,LH/FSH,WHR and BMI in treatment group were both decreased (P0.05, P0.01). Compared with the control group, WHR,BMI,FINS,LH levels in the treatment group were significantly different (P0.05). Conclusion Bushen Tiaogan recipe can improve glucose and lipid metabolism by decreasing LH,LH/FSH, in patients with non-obese PCOS, so it has therapeutic effect on non-obese PCOS.
【作者單位】： 浙江省中西醫(yī)結(jié)合醫(yī)院生殖醫(yī)學(xué)科;杭州師范大學(xué)生命與環(huán)境科學(xué)學(xué)院;
【基金】：國家名老中醫(yī)工作室科研項(xiàng)目 浙江省中醫(yī)藥管理局青年基金資助項(xiàng)目(No.2010ZQ012) 杭州市科學(xué)技術(shù)委員會重點(diǎn)專病�？祈�(xiàng)目(No.20150733Q38) 杭州市科技局課題資助項(xiàng)目(No.20100733Q24)
【分類號】：R271.9

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