【摘要】：目的:研究四神丸加味在大腸癌圍手術(shù)期治療的臨床療效,進(jìn)而探索中醫(yī)藥參與大腸癌圍手術(shù)期治療的臨床療效和應(yīng)用價(jià)值。材料與方法:搜集了116例以脾腎陽(yáng)虛為主要證候表現(xiàn)的大腸癌臨床病例,按照治療方法的不同,將其隨機(jī)分為治療組和對(duì)照組各58例,根據(jù)圍手術(shù)期術(shù)前、術(shù)后中醫(yī)證候的差異,辯證論治。治療組患者在西醫(yī)藥常規(guī)治療的基礎(chǔ)上聯(lián)合中醫(yī)藥治療,即術(shù)前1周和術(shù)后36小時(shí)開(kāi)始分別給予相應(yīng)的中藥湯劑口服。對(duì)照組患者只進(jìn)行西醫(yī)藥常規(guī)治療,然后分析比較兩組患者的臨床資料。結(jié)果:1.術(shù)后肛門排氣時(shí)間兩組比較得T=2.028,P=0.045(P0.05),其中治療組(4.103±0.831)天,對(duì)照組(4.414±0.817)天;術(shù)后住院時(shí)間兩組比較得T=2.194,P=0.030(P0.05),其中治療組(11.224±2.464)天,對(duì)照組(12.362±3.088)天。2.出現(xiàn)術(shù)后并發(fā)癥情況比較,治療組發(fā)生4例,發(fā)生率為6.7%;對(duì)照組發(fā)生14例,發(fā)生率為24.1%。其中治療組只出現(xiàn)一種并發(fā)癥的占5.2%,同時(shí)出現(xiàn)兩種并發(fā)癥為1.7%,同時(shí)出現(xiàn)3、4種的為0;對(duì)照組只出現(xiàn)一種并發(fā)癥的占24.1%,同時(shí)出現(xiàn)2、3、4種并發(fā)癥的為0。3.兩組患者在治療前后中醫(yī)癥候的改善比較,治療組要優(yōu)于對(duì)照組,治療組總有效率為91.38%,對(duì)照組總有效率為75.86%,秩和Z=-2.713,P=0.0140.05,兩組之間的差異有統(tǒng)計(jì)學(xué)意義。結(jié)論:1.四神丸加味參與大腸癌圍手術(shù)期治療的臨床療效顯著,能促進(jìn)術(shù)后胃腸功能和身體的恢復(fù),進(jìn)而縮短了術(shù)后排氣時(shí)間和住院時(shí)間,并能預(yù)防或減少術(shù)后一些并發(fā)癥的發(fā)生,能有效地改善大腸癌圍手術(shù)期的中醫(yī)癥候,提高臨床療效。2.通過(guò)四神丸加味在大腸癌圍手術(shù)期應(yīng)用的研究,體現(xiàn)出了中醫(yī)藥在大腸癌圍手術(shù)期的優(yōu)勢(shì)和臨床應(yīng)用價(jià)值,值得進(jìn)一步深入研究。
[Abstract]:Objective: to study the clinical effect of Sishen Pill in the perioperative treatment of colorectal cancer, and to explore the clinical efficacy and application value of TCM in the perioperative treatment of colorectal cancer. Materials and methods: 116 cases of colorectal cancer with deficiency of spleen and kidney yang as the main syndromes were collected and randomly divided into treatment group (58 cases) and control group (58 cases). The difference of syndrome of traditional Chinese medicine after operation, dialectical treatment. The patients in the treatment group were treated with traditional Chinese medicine combined with traditional Chinese medicine on the basis of routine treatment, I. E. 1 week before operation and 36 hours after operation. The patients in the control group were treated with routine western medicine only, and the clinical data of the two groups were analyzed and compared. The result is 1: 1. The postoperative anal exhaust time was compared between the two groups (P0.05), including the treatment group (4.103 鹵0.831) days, the control group (4.414 鹵0.817) days, the postoperative hospitalization time between the two groups (P0.05), the treatment group (11.224 鹵2.464) days, the control group (12.362 鹵3.088) days. There were 4 cases in the treatment group (6.7%) and 14 cases in the control group (24.1%). Among them, only one complication occurred in the treatment group (5.2%), two kinds of complications (1.7%) and three kinds of complications (0%) in the treatment group, while in the control group there was only one complication (24.1%) and the other two complications (0.3%). The improvement of TCM symptoms in the two groups before and after treatment, the treatment group is better than the control group, the total effective rate of the treatment group is 91.38, the total effective rate of the control group is 75.86. Conclusion 1. The clinical effect of Sishen Pill in the perioperative treatment of colorectal cancer is remarkable. It can promote the recovery of gastrointestinal function and body after operation, thus shorten the time of exhaust and hospital stay after operation, and can prevent or reduce the occurrence of some postoperative complications. Can effectively improve the perioperative period of colorectal cancer TCM symptoms, improve the clinical efficacy. 2. The application of Sishen Pill in the perioperative period of colorectal cancer shows the advantages and clinical application value of TCM in perioperative period of colorectal cancer, which is worthy of further study.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R273
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本文編號(hào)：2218938