發(fā)布時(shí)間：2018-08-29 17:25

【摘要】：目的:觀察下氣湯加減治療中虛氣滯型胃食管反流病(GERD)患者的臨床癥狀改善情況,從理論和臨床研究?jī)煞矫嬗懻摎鈾C(jī)升降理論在GERD病機(jī)、辨證及治療中的作用,提供治療的新思路和新方藥。方法:將60名符合納入標(biāo)準(zhǔn)的中虛氣滯型GERD患者,隨機(jī)分為試驗(yàn)組(例)和對(duì)照組(30例),試驗(yàn)組給予下氣湯加減(每日1副),對(duì)照組給予雷貝拉唑腸溶膠囊(早晚餐前各1粒),療程均為8周,觀察兩組在治療前,治療4周及8周后,臨床癥狀、體征、不良反應(yīng)等方面的變化,并對(duì)情況進(jìn)行記錄、分析,并電話隨訪,觀察長(zhǎng)期療效及復(fù)發(fā)情況。結(jié)果:兩組藥物對(duì)均有一定的療效,試驗(yàn)組8周總有效率為93.4%,高于對(duì)照組76.7%,試驗(yàn)組療效更優(yōu)(P0.05)。中醫(yī)癥狀積分比較顯示:兩組藥物均有效果,試驗(yàn)組優(yōu)于對(duì)照組(P0.05),且在緩解反酸、胃脹、便溏、咽異感等方面的效果優(yōu)于對(duì)照組(P0.05)。GERD-HRQL積分比較,亦顯示試驗(yàn)組有更好的臨床療效(P0.05)。試驗(yàn)組無(wú)論在中醫(yī)癥狀積分、GERD-HRQL積分還是總有效率,治療8周,療效均優(yōu)于治療4周(P0.05)。結(jié)論:下氣湯加減治療GERD(中虛氣滯型)患者的療效優(yōu)于標(biāo)準(zhǔn)治療。且在改善食管外癥狀方面有更好的療效,是臨床治療GERD(中虛氣滯型)的有效方法,有進(jìn)一步研究的價(jià)值。治療周期建議為8周。
[Abstract]:Objective: to observe the improvement of clinical symptoms of patients with moderate deficiency of qi stagnation gastroesophageal reflux disease (GERD) treated by Xiaqi decoction, and to discuss the role of Qi mechanism ascending and descending theory in the pathogenesis, syndrome differentiation and treatment of GERD from two aspects: theory and clinical study. To provide new ideas and new prescriptions for treatment. Methods: sixty GERD patients with moderate asthenia and Qi stagnation were included in the study. They were randomly divided into the experimental group (n = 30) and the control group (n = 30). The experimental group was treated with Xiaqi decoction (1 pair per day) and the control group (1 capsule before the morning and evening meal) for 8 weeks. After 4 weeks and 8 weeks of treatment, the changes of clinical symptoms, signs and adverse reactions were recorded, analyzed and followed up by telephone to observe the long-term curative effect and recurrence. Results: both groups had certain curative effects. The total effective rate of the experimental group was 93.4w, which was higher than that of the control group (76.7g). The effect of the trial group was better than that of the control group (P0.05). TCM symptom score comparison showed that: the two groups of drugs are effective, the experimental group is better than the control group (P0.05), and in the relief of acid, stomach distention, loose stools, pharynx and other aspects of the effect is better than the control group (P0.05). GERD-HRQL score comparison, also shows that the experimental group has a better clinical efficacy (P0.05). In the experimental group, the GERD-HRQL score or the total effective rate were better than that of the treatment for 4 weeks after 8 weeks of treatment (P0.05). Conclusion: Xiaqi decoction is superior to standard treatment in treating GERD patients. It is an effective method for the treatment of GERD (deficiency of Qi stagnation) and has the value of further study. The treatment cycle is recommended for 8 weeks.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R259

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本文編號(hào)：2211902