【摘要】：目的研究薏苡莖的水提物和醇提物對小鼠S180肉瘤的抑制作用。方法無特定病原體(SFP)的昆明小鼠腋下接種1×107cell·m L~(-1)S180肉瘤細胞0.4 m L,持續(xù)6~8周。然后按照體重將小鼠隨機分為5組:空白組(0.9%Na Cl)、對照組(環(huán)磷酰胺:20μg·g~(-1)·d~(-1))、大、中、小3個劑量實驗組(薏苡莖的水提物或醇提物:100,50,25 mg·m L~(-1)),連續(xù)灌胃或尾靜脈注射10 d。剝離腫瘤、脾并進行稱重,計算出腫瘤抑制率。結果薏苡莖水提物大中小3個劑量實驗組對S180肉瘤的抑制率分別為32.11%,75.63%,11.41%;薏苡莖醇提物大、中、小3個劑量實驗組對S180肉瘤的抑制率分別為77.09%,80.03%,73.52%。結論莖水提與莖醇提的各劑量組對小鼠S180肉瘤具有不同程度的抑制作用,且藥物不良反應比較小;莖水提的最佳抑制劑量為500 mg·kg~(-1)·d~(-1)。
[Abstract]:Objective to study the inhibitory effect of water extract and alcohol extract of Coix lachrymae stem on S180 sarcoma in mice. Methods Kunming mice without specific pathogen (SFP) were inoculated with 1 脳 107cell mL ~ (-1) S180 sarcoma cells for 6 weeks. Then the mice were randomly divided into 5 groups according to their body weight: blank group (0.9%Na Cl), control group: 20 渭 g g ~ (-1) d ~ (-1), medium and small doses: water extract from Coix stem or alcohol extract: 100m ~ (50) mg mL ~ (-1),) or caudal vein injection for 10 days. The tumor was stripped, the spleen was weighed and the tumor inhibition rate was calculated. Results the inhibition rates of S180 sarcoma in the three experimental groups were 32.11, 75.63 and 11.41, respectively, and the inhibition rates of the three experimental groups on S180 sarcoma were 77.09, 80.03 and 73.52, respectively. Conclusion different doses of stem water extraction and stem alcohol extraction have different inhibitory effects on S180 sarcoma in mice, and the adverse drug reaction is relatively small, and the best inhibitory dose of stem water extraction is 500 mg kg~ (-1) d ~ (-1).
【作者單位】： 右江民族醫(yī)學院科技處實驗動物中心;右江民族醫(yī)學院藥學院;右江民族醫(yī)學院臨床醫(yī)學院;右江民族醫(yī)學院廣西高校右江流域特色民族藥研究重點實驗室;
【基金】：國家自然科學基金資助項目(81360684) 廣西自然科學基金資助項目(2011GXNSFA018046) 廣西中醫(yī)藥科技專項基金資助項目(GZKZ10-128) 廣西教育廳基金資助項目(201106LX425) 廣西中醫(yī)藥管理局基金資助項目(gzzc1047) 廣西醫(yī)學科學實驗中心開放專項基金資助項目(KFJJ2011-04)
【分類號】：R29

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