【摘要】：目的:探討高膽固醇血癥與肱踝脈搏波傳導速度(bapwv)的相關(guān)性,初步探討高膽固醇血癥與中醫(yī)體質(zhì)的相關(guān)性,及bapwv與中醫(yī)體質(zhì)的相關(guān)性,為動脈硬化的早期發(fā)現(xiàn)和心血管疾病的危險分層提供中西醫(yī)理論依據(jù),指導臨床治療。材料與方法:選取2016年6月-2016年12月于我院心內(nèi)科門診體檢者84例為研究對象,其中高膽固醇血癥者為觀察組共43例,其中男17例,女26例,平均年齡61.26±10.14歲;血脂正常者為對照組共41例,其中男16例,女25例,平均年齡57.88±11.90歲。西醫(yī)診斷標準參照《2016年ESC/EAS血脂異常管理指南》制定,中醫(yī)體質(zhì)分型及標準參照《中醫(yī)體質(zhì)分類判定表》結(jié)合舌、脈進行評估,bapwv的檢測采用日本VS-1000動脈硬化診斷儀進行檢測。入組患者進行基本資料錄入和病史情況采集,并填寫中醫(yī)體質(zhì)分類判定表。所有數(shù)據(jù)采用SPSS17.0統(tǒng)計軟件分析,P0.05說明差異具有顯著性。結(jié)果:1.bapwv與總膽固醇水平成正相關(guān)。2.高膽固醇血癥組體質(zhì)以血瘀質(zhì)居多,其次分別為痰濕質(zhì)和平和質(zhì);對照組體質(zhì)以平和質(zhì)居多,其次分別為陽虛質(zhì)和濕熱質(zhì)。3.痰濕質(zhì)、血瘀質(zhì)為高膽固醇血癥的危險體質(zhì)。4.高膽固醇血癥組體質(zhì)間bapwv值的比較:氣虛質(zhì)血瘀質(zhì)濕熱質(zhì)陽虛質(zhì)痰濕質(zhì)陰虛質(zhì)平和質(zhì)氣郁質(zhì)。結(jié)論:高膽固醇血癥與肱踝脈搏波傳導速度存在正相關(guān)關(guān)系,通過分析高膽固醇血癥患者的bapwv結(jié)果綜合評估其動脈硬化程度,為動脈硬化的早期發(fā)現(xiàn)和評估心血管疾病風險提供理論依據(jù)。通過對個體中醫(yī)體質(zhì)的評定,及時干預高危體質(zhì),“治未病”未病先防,對降低疾病的發(fā)病率有著重要意義。
[Abstract]:Objective: to investigate the correlation between hypercholesterolemia and brachial pulse wave velocity (bapwv), the relationship between hypercholesterolemia and TCM constitution, and the correlation between bapwv and TCM constitution. To provide theoretical basis for early detection of arteriosclerosis and risk stratification of cardiovascular disease, guiding clinical treatment. Materials and methods: from June 2016 to December 2016, 84 patients with hypercholesterolemia were selected as the study subjects, including 17 males and 26 females, with an average age of 61.26 鹵10.14 years. There were 41 normal blood lipids in the control group, including 16 males and 25 females, with an average age of 57.88 鹵11.90 years. The diagnostic criteria of western medicine were formulated according to the guidelines for the management of ESC/EAS dyslipidemia in 2016. The constitution classification of TCM and the criteria of TCM constitution classification were combined with tongue and pulse to evaluate the blood vessel. The VS-1000 arteriosclerosis diagnostic instrument of Japan was used to test the diagnostic criteria. The basic data and medical history were collected, and the TCM constitution classification form was filled out. All the data were analyzed by SPSS17.0 statistical software (P0.05). Results: 1. Bapwv was positively correlated with total cholesterol level. In hypercholesterolemia group, blood stasis was the most, followed by phlegm dampness, peace and quality, in control group, Yang deficiency and damp-heat were followed. 3. Phlegm dampness and blood stasis are dangerous constitution of hypercholesterolemia. Comparison of bapwv values between the hypercholesterolemia group: Qi deficiency blood stasis dampness heat Yang deficiency phlegm wet yin deficiency and qi stagnation. Conclusion: there is a positive correlation between hypercholesterolemia and brachial pulse wave velocity. The degree of arteriosclerosis was evaluated by analyzing the bapwv results of hypercholesterolemia patients. To provide theoretical basis for early detection and assessment of cardiovascular disease risk of atherosclerosis. It is of great significance to reduce the incidence of disease by evaluating the physique of individual TCM, intervening in high risk constitution in time and preventing the disease before treatment.
【學位授予單位】：遼寧中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R259

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