現(xiàn)代嶺南名醫(yī)肺系醫(yī)案收集整理及肺脹證治規(guī)律與臨床觀察研究
[Abstract]:OBJECTIVE: To establish a modern (1949-present) lung system medical record database of famous and old Chinese medicine in Lingnan, and apply data mining technology to systematically study the medical records of lung distension, summarize the rules of syndrome and treatment of lung distension by famous doctors in Lingnan, in order to rescue and inherit the academic experience of famous and old Chinese medicine, study and exert the advantages of regional Chinese medicine resources and clinical characteristics. In addition, the basic prescriptions of pulmonary distention extracted from data mining were used to carry out clinical observation and Study on patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), in order to give full play to the characteristics of Lingnan medicine and expand the treatment of traditional Chinese medicine for AECOPD. Methods: 1. Collecting and sorting out the existing medical records of famous and old Lingnan traditional Chinese medicine treating pulmonary diseases and syndromes by means of library, on-the-spot collection in the literature library, searching and downloading the periodical literature database, and so on. By using SPSS17.0 and IBM SPSS Modeler 14.1 statistical software, data mining methods such as frequency analysis, factor analysis, system clustering analysis and Apriori association rules were used to systematically study the rule of syndrome and treatment of pulmonary distention. Combined with professional knowledge, the clinical thinking of famous doctors in Lingnan for treating pulmonary distention and the law of medication were analyzed. 2. Secondly, the above data mining was carried out. Methods Sixty-six patients with AECOPD were randomly divided into control group and treatment group. The control group was treated with routine western medicine. The treatment group was treated with Jianpi Jiangqi Fang on the basis of the control group. The clinical symptoms and signs integral, white blood cell count and blood gas analysis index were selected as the observation indexes. Results: 1. A total of 50 books and 112 papers were collected, including 106 journals, 3 dissertations, 2 papers and 1 online journal. A total of 392 medical records and 743 effective prescriptions were collected, including 111 colds. There were 166 cough, 86 asthma, 74 asthma, 21 lung carbuncle, 10 flaccidity, 94 lung distention, 38 tuberculosis, 56 hemoptysis and 87 lung cancer. The database of lung system medical records of famous old Chinese medicine in Lingnan was preliminarily formed. 2. The data mining results of lung distention medical records analyzed the effective diagnosis and treatment information of 47 cases of 94 lung distention medical records collected. The total symptoms were 90 kinds and 82 kinds. The main symptoms were phlegm expectoration, shortness of breath, cough, white phlegm, viscous phlegm, loss of appetite, etc. The frequency of tongue symptoms was 318 times of 20 kinds, of which the frequency of tongue paleness was the highest, accounting for 17.61%, followed by white fur, red tongue, dark tongue, greasy fur, yellow fur, etc. Among them, the frequency of lung-qi deficiency syndrome was the highest, accounting for 23.78%, followed by spleen-qi deficiency syndrome and kidney-yang deficiency syndrome; the frequency of phlegm-dampness obstructing lung syndrome was the highest, accounting for 10.89%, followed by phlegm-stasis obstructing lung syndrome, water-drinking overflow syndrome, phlegm-heat obstructing lung syndrome and so on. Ling, white atractylodes macrocephala, orange peel, bitter almond, Codonopsis pilosula, Schisandra chinensis, Perilla frutescens and other 35 kinds of medicines appear frequently, the cumulative frequency is 72.16%. In Lingnan genuine medicinal materials, such as orange peel, cinnamon, Huatanghong, Wuzhi peach, Guangdilong, Qingtiankui are used frequently. Phlegm antitussive and antiasthmatic drugs, antipyretic drugs, diuresis and dampness drugs, Qi-Regulating drugs and so on, famous and old traditional Chinese medicine in Lingnan area treats lung distention syndrome with strengthening the right and eliminating evil as the general principle, nourishing deficiency and selecting more qi, nourishing yin and warming Yang products, eliminating evil according to the nature of the disease, respectively adopt the treatment methods of reducing qi, expelling phlegm, clearing away heat and toxin, relieving edema, regulating qi and stopping cough. The high-frequency drugs were analyzed by factor analysis and cluster analysis, and 11 kinds and 8 kinds of drug combinations were obtained. They reflected the etiology and pathogenesis of pulmonary distention from different perspectives, the thinking characteristics and prescription principles of famous doctors in Lingnan. Twenty-four groups of commonly used triple drug combinations, such as Semen Raphani, White Mustard, Perilla Fructus, etc. According to the characteristics of lung distension in Lingnan area, such as deficiency and excess of lung distension, spleen deficiency and dampness, Qi disorder, phlegm and blood stasis, mixed cold and heat, the famous doctors in Lingnan have the following characteristics: strengthening the body and dispelling evil, giving consideration to both the specimen; strengthening the spleen and removing dampness, cultivating the earth to produce gold; ascending and descending in and out, regulating qi; resolving phlegm and promoting blood circulation and removing blood stasis; combining cold and temperature according to local conditions; The total effective rate was 93.55% in the treatment group and 80.65% in the control group. There was significant difference between the two groups (P 0.05), indicating that the total curative effect of the treatment group was better than that of the control group. The symptoms and signs of cough, expectoration, asthma, nausea, abdominal distention and Pa02/FiO2, PaCO2 in the treatment group were significantly improved compared with those in the control group (P The most centralized rule in the application of pulmonary distention is to make up for the benefit, relieve phlegm, relieve cough and relieve asthma; the etiology and pathogenesis of pulmonary distention and the combinations of commonly used drugs for the treatment of pulmonary distention can be obtained by factor and cluster analysis, and the basic prescriptions and medicines can be summarized; the deep relationship among pulmonary distention drugs, symptoms, medicines, syndromes and medicines can be obtained by association It can not only make the experience of famous and old Chinese medicine more intuitive and easier to understand, but also can carry out repetitive operation. Using data mining technology to analyze the massive information of TCM diagnosis and treatment is helpful to discover the key rules hidden in the links of TCM syndrome differentiation and treatment, prescription medication and so on. It is helpful to promote the inheritance, development and innovation of TCM, and further promote the development of TCM. 3. Medical records embody the comprehensive application of TCM diagnosis and treatment, and play an important and irreplaceable role in the inheritance of TCM academic experience. The study of medical records is an effective way to summarize and inherit famous TCM experience. 4. The treatment of AECOPD combined with phlegm dampness obstructing lung syndrome by invigorating spleen and reducing phlegm can alleviate impending clinical symptoms. Bed symptoms, improve lung blood gas analysis, clinical efficacy is obvious, no adverse reactions, for Jianpi Jiangqi phlegm method for the treatment of Lingnan AECOPD and phlegm dampness obstruction of lung syndrome provides clinical basis, and for the acute exacerbation of COPD provides a new means of treatment. Medical case analysis, and can get objective, practical and instructive conclusions for clinical work. Clinical research found that: Jianpi Jiangqi Phlegm method for the treatment of AECOPD phlegm dampness obstruction syndrome has a definite effect.
【學(xué)位授予單位】:廣州中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】:博士
【學(xué)位授予年份】:2016
【分類號(hào)】:R249;R256.14
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