【摘要】：目的評價清瘟敗毒飲合大承氣湯加減輔助治療肺炎膿毒癥初期(毒熱內(nèi)盛證、瘀毒內(nèi)阻證)的臨床療效并探討分析其作用機制,為臨床中西醫(yī)結(jié)合治療肺炎膿毒癥探索新途徑。方法選擇于2015年4月-2016年4月入住山東省中醫(yī)藥大學附屬醫(yī)院急診科及ICU病房的符合肺炎膿毒癥初期診斷標準的患者60例,隨機分為試驗組(30例,采用西醫(yī)常規(guī)治療+清瘟敗毒飲合大承氣湯加減組方中藥治療),對照組(30例,采用西醫(yī)常規(guī)治療),進行前瞻性對照研究。入院24小時內(nèi)及療程結(jié)束時分別進行實驗室檢查、SPACHEII評分、中醫(yī)證候總積分、各單項癥狀等指標觀察比較。采用SPSS 17.0軟件進行統(tǒng)計分析。結(jié)果經(jīng)過治療7天后,試驗組及對照組比較存在限制性差異(P0、05)。同時,SPACHEII評分、白細胞總數(shù)(WBC)、降鈣素原(PCT)、C反應(yīng)蛋白(CRP)、中醫(yī)證候總積分明顯降低(P0、05或P0、01),各單項中醫(yī)臨床癥狀的改善試驗組明顯優(yōu)于對照組,具有顯著性差異(P0.01)。結(jié)論清瘟敗毒飲合大承氣湯加減組方對肺炎膿毒癥初期有較好的干預(yù)治療作用。
[Abstract]:Objective to evaluate the clinical efficacy of Qingwen Baidu Yin combined with Dachengqi decoction in the treatment of pneumonia sepsis at the early stage of pneumonia sepsis (toxic heat and internal obstruction syndrome) and to explore the mechanism of its effect and explore a new approach for the treatment of pneumonia sepsis by integrating traditional Chinese and western medicine. Methods from April 2015 to April 2016, 60 patients admitted to the emergency department and ICU ward of the affiliated Hospital of Shandong University of traditional Chinese Medicine were selected to meet the initial diagnostic criteria for pneumonia sepsis, and were randomly divided into the experimental group (30 cases), and the control group (30 cases). Western medicine was used to treat Qingwen Baidu Yin combined with Dachengqi decoction. The control group (30 cases, treated by routine western medicine) was carried out a prospective control study. Within 24 hours of admission and at the end of the course of treatment, the scores of SPACHEII, the total score of TCM syndromes and the symptoms of each single item were observed and compared. SPSS 17.0 software was used for statistical analysis. Results after 7 days of treatment, there was a restrictive difference between the experimental group and the control group (P0. 05). At the same time, the score of SPACHEII and the total score of TCM syndromes of (WBC), procalcitonin (PCT) C reactive protein (CRP),) were significantly decreased (P00.05 or P00.01). The improvement of clinical symptoms of each single TCM in the experimental group was obviously superior to that in the control group (P0.01). Conclusion Qingwen septic decoction combined with Dachengqi decoction has better effect on the treatment of pneumonia sepsis at the initial stage.
【學位授予單位】：山東中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

【相似文獻】

相關(guān)期刊論文 前10條

1 姚詠明,盛志勇;膿毒癥研究的若干新動態(tài)[J];中國危重病急救醫(yī)學;2000年06期

2 菲琳;;治療膿毒癥的新希望[J];國外醫(yī)學情報;2002年10期

3 向陽;防止膿毒癥自高動力相轉(zhuǎn)向低動力相的新途徑[J];國外醫(yī)學.外科學分冊;2003年03期

4 任新生;重新認識全身炎癥反應(yīng)綜合征、膿毒癥和多器官功能衰竭綜合征[J];中華急診醫(yī)學雜志;2004年02期

5 崔德健;探討膿毒癥診斷和治療新策略[J];中國呼吸與危重監(jiān)護雜志;2004年03期

6 林洪遠;膿毒癥診斷和治療進展[J];中國實用外科雜志;2004年06期

7 湯耀卿;膿毒癥的定義和診斷[J];臨床外科雜志;2004年11期

8 王小平;膿毒癥研究現(xiàn)狀[J];實用臨床醫(yī)學;2005年06期

9 周國勇;性別與膿毒癥嚴重程度的關(guān)系[J];中國危重病急救醫(yī)學;2005年07期

10 黎永明;姜勇;;膿毒癥發(fā)生機制的新進展[J];感染.炎癥.修復(fù);2005年01期

相關(guān)會議論文 前10條

1 張麗葳;奚希相;張威;張莉芬;陳昊;李俊;楊興易;;以血小板減少為主要表現(xiàn)的膿毒癥搶救一例[A];《中華急診醫(yī)學雜志》第八屆組稿會暨急診醫(yī)學首屆青年論壇論文匯編[C];2009年

2 張振輝;林s鉅，

本文編號：2172255