芪術(shù)益氣湯治療中老年慢性功能性便秘（氣血虧虛證）的臨床研究
發(fā)布時間：2018-07-28 16:09
【摘要】：目的:觀察芪術(shù)益氣湯治療中老年慢性功能性便秘中辨證為氣血虧虛證的臨床療效,為治療慢性功能性便秘提供臨床參考。方法:選擇中老年患者中符合氣血虧虛證的慢性功能性便秘診斷標(biāo)準(zhǔn)的病例60例,將其隨機分成試驗組30例及對照組30例。兩組患者于治療前在性別、年齡、病程、治療前病情嚴(yán)重程度、中醫(yī)癥候總積分等方面均無統(tǒng)計學(xué)差異。試驗組給予自擬中藥芪術(shù)益氣湯,水煎至400ml,分早晚兩次溫服,日一劑;對照組給予口服聚乙二醇4000散(商品名稱:福松,規(guī)格:10g/袋),口服,1袋/次,2次/日。服藥時間均為4周,用藥時間結(jié)束后4周隨訪,觀察治療后、治療后4周中醫(yī)癥候總積分療效、復(fù)發(fā)率及安全性。兩組患者于治療前后、治療后4周的結(jié)果用統(tǒng)計學(xué)方法分析和處理,并進行組內(nèi)、組間的比較。結(jié)果:臨床研究觀察顯示,試驗組痊愈4例,顯效15例,有效9例,無效2例,總有效率為93.33%;對照組痊愈1例,顯效10例,有效13例,無效6例,總有效率為80.00%;在中醫(yī)癥候總積分方面,兩組于治療后、治療后4周均較治療前有顯著改善(P0.01),治療后的改善均顯著優(yōu)于治療后4周(P0.01);治療后,試驗組中醫(yī)癥候總積分的改善優(yōu)于對照組(P0.05),提示治療后在中醫(yī)癥候總積分療效上試驗組優(yōu)于對照組;治療后4周,兩組在中醫(yī)癥候總積分方面的改善無統(tǒng)計學(xué)差異(P0.05);治療后4周,對兩組患者中治療療效為痊愈、顯效及有效者隨訪并進行中醫(yī)癥狀評分,中醫(yī)癥候總積分治療結(jié)束后4周較治療前≥50%者即為復(fù)發(fā),試驗組復(fù)發(fā)率為32.14%,對照組復(fù)發(fā)率為50.00%,經(jīng)統(tǒng)計學(xué)方法分析,兩組于治療后4周的遠(yuǎn)期療效無統(tǒng)計學(xué)差異(P0.05)。此次臨床應(yīng)用芪術(shù)益氣湯治療過程中,未發(fā)現(xiàn)明顯不良反應(yīng)。結(jié)論:芪術(shù)益氣湯治療氣血虧虛證的中老年慢性功能性便秘有較好的臨床療效,可明顯改善患者的臨床癥狀,提高患者的生活質(zhì)量。
[Abstract]:Objective: to observe the clinical effect of Qizu Yiqi decoction in treating senile chronic functional constipation with syndrome differentiation as deficiency of qi and blood and to provide clinical reference for the treatment of chronic functional constipation. Methods: sixty cases of chronic functional constipation with deficiency of qi and blood were randomly divided into experimental group (n = 30) and control group (n = 30). There was no significant difference between the two groups in sex, age, course of disease, severity of illness before treatment, total score of TCM symptoms and so on. The experimental group was given Qizu Yiqi decoction, a self-made Chinese medicine, fried to 400ml, divided into morning and evening warm clothes, one dose per day, while the control group was given oral polyethylene glycol 4000 powder (commodity name: Fusong, size: 10 g / bag), oral 1 bag per day, 2 times a day. All the patients were treated for 4 weeks, followed up for 4 weeks after the end of the medication. The total integral effect, recurrence rate and safety of TCM symptoms were observed 4 weeks after treatment. Two groups of patients before and after treatment, 4 weeks after treatment with statistical analysis and treatment of results, and carry out intra-group, inter-group comparison. Results: clinical observation showed that 4 cases were cured, 15 cases were effective, 9 cases were effective, 2 cases were ineffective, and the total effective rate was 93.33g in the experimental group, while in the control group, 1 case was cured, 10 cases were markedly effective, 13 cases were effective, 6 cases were ineffective. The total effective rate was 80.00.The total score of TCM symptoms in both groups was significantly improved 4 weeks after treatment (P0.01), and the improvement after treatment was significantly better than that after treatment (P0.01). The improvement of the total integral of TCM symptoms in the experimental group was better than that in the control group (P0.05), suggesting that the experimental group was superior to the control group in the curative effect of the total integral of TCM syndrome after treatment, and 4 weeks after treatment, There was no significant difference in the improvement of the total integral of TCM symptoms between the two groups (P0.05). 4 weeks after treatment, the curative effect of the two groups was cured, marked and effective, followed up with TCM symptom score. The recurrence rate of the experimental group was 32.14 and that of the control group was 50.0.The long-term curative effect of the two groups was not significantly different after 4 weeks of treatment (P0.05). The clinical application of Qizhu Yiqi decoction treatment process, no obvious adverse reactions. Conclusion: Qizhu Yiqi decoction has good clinical effect in treating chronic functional constipation with deficiency of qi and blood. It can obviously improve the clinical symptoms and improve the quality of life of the patients.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R256.35
本文編號：2150839
[Abstract]:Objective: to observe the clinical effect of Qizu Yiqi decoction in treating senile chronic functional constipation with syndrome differentiation as deficiency of qi and blood and to provide clinical reference for the treatment of chronic functional constipation. Methods: sixty cases of chronic functional constipation with deficiency of qi and blood were randomly divided into experimental group (n = 30) and control group (n = 30). There was no significant difference between the two groups in sex, age, course of disease, severity of illness before treatment, total score of TCM symptoms and so on. The experimental group was given Qizu Yiqi decoction, a self-made Chinese medicine, fried to 400ml, divided into morning and evening warm clothes, one dose per day, while the control group was given oral polyethylene glycol 4000 powder (commodity name: Fusong, size: 10 g / bag), oral 1 bag per day, 2 times a day. All the patients were treated for 4 weeks, followed up for 4 weeks after the end of the medication. The total integral effect, recurrence rate and safety of TCM symptoms were observed 4 weeks after treatment. Two groups of patients before and after treatment, 4 weeks after treatment with statistical analysis and treatment of results, and carry out intra-group, inter-group comparison. Results: clinical observation showed that 4 cases were cured, 15 cases were effective, 9 cases were effective, 2 cases were ineffective, and the total effective rate was 93.33g in the experimental group, while in the control group, 1 case was cured, 10 cases were markedly effective, 13 cases were effective, 6 cases were ineffective. The total effective rate was 80.00.The total score of TCM symptoms in both groups was significantly improved 4 weeks after treatment (P0.01), and the improvement after treatment was significantly better than that after treatment (P0.01). The improvement of the total integral of TCM symptoms in the experimental group was better than that in the control group (P0.05), suggesting that the experimental group was superior to the control group in the curative effect of the total integral of TCM syndrome after treatment, and 4 weeks after treatment, There was no significant difference in the improvement of the total integral of TCM symptoms between the two groups (P0.05). 4 weeks after treatment, the curative effect of the two groups was cured, marked and effective, followed up with TCM symptom score. The recurrence rate of the experimental group was 32.14 and that of the control group was 50.0.The long-term curative effect of the two groups was not significantly different after 4 weeks of treatment (P0.05). The clinical application of Qizhu Yiqi decoction treatment process, no obvious adverse reactions. Conclusion: Qizhu Yiqi decoction has good clinical effect in treating chronic functional constipation with deficiency of qi and blood. It can obviously improve the clinical symptoms and improve the quality of life of the patients.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R256.35
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