【摘要】：研究目的：觀察虛秘合劑對功能性便秘(氣血虧虛型)的臨床療效及安全性,并初步探討其作用機理,為治療該病提供新的思路及方法。研究方法：收集綿陽市中醫(yī)院2014年4月～2015年2月在消化內(nèi)科專家門診就診的患者,符合納入標(biāo)準(zhǔn)的40例,隨機分為治療組和對照組,兩組各20例。其中治療組給予虛秘合劑,對照組給予聚乙二醇4000散,療程均為4周,觀察治療前后證候變化情況,比較兩組治療前后的療效及安全性等。研究結(jié)果：1、經(jīng)過4周治療后,治療組總有效率85.0%,對照組總有效率為60.0%,兩組間有效率比較具有統(tǒng)計學(xué)意義(P0.05),治療組療效優(yōu)于對照組。治療組、對照組治療前后積分均存在差異(P0.05),治療組癥狀的改善優(yōu)于對照組。2、在排便困難、排便時間、糞便性狀、排便間隔、腹痛腹脹等癥狀積分的比較上,差異無統(tǒng)計學(xué)意義(P0.05),兩組在改善上述癥狀方面療效相似。而對神疲懶言、少食納呆、體倦乏力、下墜不盡脹感的癥狀進行比較,差異具有統(tǒng)計學(xué)意義(P0.05),結(jié)合兩組癥狀有效率的比較,可以得出治療組和對照組對于癥狀改善均有效,而在次癥的改善方面,治療組療效優(yōu)于對照組。3、治療組在服藥期間患者均未出現(xiàn)明顯不適癥狀及毒副作用,對照組2例患者服藥期間出現(xiàn)一過性輕微腹痛、腹瀉,不影響繼續(xù)服藥。兩組病例在接受治療期間監(jiān)測相關(guān)安全指標(biāo)均未見明顯異常變化。4、在經(jīng)過4周的治療后,對治療有效的患者進行1個月的隨訪,治療組復(fù)發(fā)3例,對照組復(fù)發(fā)7例,兩組復(fù)發(fā)率分別為17.6%、58.3%。兩組復(fù)發(fā)率存在差異,有統(tǒng)計學(xué)意義(P0.05)。結(jié)論：虛秘合劑治療功能性便秘(氣血虧虛型)療效可靠,未見明顯不良反應(yīng),復(fù)發(fā)率低,值得進一步研究和臨床推廣。
[Abstract]:Objective: to observe the clinical efficacy and safety of deficiency decoction on functional constipation (deficiency of qi and blood), and to explore its mechanism, and to provide new ideas and methods for the treatment of this disease. Methods: 40 patients in Mianyang traditional Chinese Medicine Hospital from April 2014 to February 2015 were randomly divided into treatment group and control group with 20 cases in each group. The treatment group was treated with deficiency constipation mixture, the control group was given polyethylene glycol 4000 powder for 4 weeks, the changes of syndrome were observed before and after treatment, and the efficacy and safety of the two groups were compared before and after treatment. Results: after 4 weeks of treatment, the total effective rate of the treatment group was 85.0, the total effective rate of the control group was 60.00.The effective rate of the two groups was statistically significant (P0.05). The curative effect of the treatment group was better than that of the control group. The scores of treatment group and control group were significantly different before and after treatment (P0.05). The improvement of symptoms in treatment group was better than that in control group. The scores of defecation difficulty, defecation time, fecal character, defecation interval, abdominal pain and abdominal distension were compared. The difference was not statistically significant (P0.05), the two groups in the improvement of the symptoms of similar efficacy. On the other hand, the symptoms of fatigue, less food intake, fatigue and undistension were compared, and the difference was statistically significant (P0.05). In combination with the comparison of the effective rate of symptoms between the two groups, it can be concluded that the treatment group and the control group are effective for the improvement of symptoms. In the improvement of the secondary symptoms, the curative effect of the treatment group was better than that of the control group. The patients in the treatment group had no obvious symptoms of discomfort and side effects during the period of taking medicine, while the two patients in the control group had transient mild abdominal pain and diarrhea during the treatment period. Does not affect the continuation of medication. After 4 weeks of treatment, the patients with effective treatment were followed up for one month. There were 3 cases of recurrence in the treatment group and 7 cases in the control group, and there were 3 cases of recurrence in the treatment group and 7 cases in the control group after 4 weeks of treatment, and there were 3 cases of recurrence in the treatment group and 7 cases in the control group. The recurrence rate of the two groups was 17.6 and 58.3 respectively. There was significant difference in recurrence rate between the two groups (P0.05). Conclusion: the treatment of functional constipation (deficiency of qi and blood deficiency type) with deficiency of constipation is reliable, no obvious adverse reactions and low recurrence rate, which is worthy of further study and clinical popularization.
【學(xué)位授予單位】：成都中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R256.35

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