【摘要】：腫瘤微環(huán)境的免疫抑制和能量代謝障礙在病機上以脾虛為主,甚則及腎。腫瘤微環(huán)境對腫瘤細胞進行了重新編程,是癌毒轉化的關鍵因素,并賦予腫瘤干細胞(CSCs)分化潛能和干性,CSCs是至虛之處的毒根深藏。扶正祛邪是改善腫瘤微環(huán)境的中醫(yī)抗癌總綱。理解扶正與祛邪的關系,扶正能否調控微環(huán)境改變腫瘤細胞與CSCs之間的轉化?祛邪能否拔除癌毒而改善微環(huán)境?在腫瘤微環(huán)境與中醫(yī)抗癌策略之間建立溝通,體現(xiàn)中醫(yī)整體觀在癌癥辨治方面的智慧。
[Abstract]:Immunosuppressive and energy metabolism disorders in tumor microenvironment were mainly spleen deficiency and kidney. Tumor microenvironment reprogramming tumor cells is the key factor of carcinotoxic transformation and endows tumor stem cells with the potential of differentiation and dryness. Nourishing qi and dispelling evil is the general principle of anti-cancer of traditional Chinese medicine to improve the microenvironment of tumor. Understanding the relationship between Fuzheng and dispelling evil, can Fuzheng regulate the microenvironment to change the transformation between tumor cells and CSCs? Can remove cancer poison and improve microenvironment? To establish a communication between tumor microenvironment and TCM anticancer strategy, to reflect the wisdom of TCM holistic view in cancer differentiation and treatment.
【作者單位】： 南方醫(yī)科大學中西醫(yī)結合醫(yī)院;南方醫(yī)科大學中醫(yī)藥學院;
【基金】：國家自然科學基金面上項目(No.81573848,No.81774172) 廣東省自然科學基金項目(No.2014A030313323) 廣州市科技計劃項目(No.20160701014) 廣東省中醫(yī)藥局科研項目(No.20161161,No.20162002)~~
【分類號】：R273

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