【摘要】：目的：近年來,隨著人們物質(zhì)生活水平提高,現(xiàn)代工業(yè)技術快速發(fā)展,食物、環(huán)境污染不斷加重以及激素、化妝品濫用等,面部皮炎作為一種損容性疾病,其發(fā)病率正逐年上升。其發(fā)病機理目前尚未完全清楚,但是如何有效地治愈面部皮損,達到良好提高患者生活質(zhì)量、恢復患者身心健康是皮膚科臨床亟待解決的重要課題。本課題旨在通過口服簡化消風散聯(lián)合紫草軟膏及氟芬那酸丁酯軟膏外用治療面部皮炎的臨床研究比較,探討紫草軟膏治療面部皮炎的臨床療效及作用機理。方法：將符合納入標準的88例受試者隨機分為2組,每組44例。兩組患者均以口服中藥(簡化消風散加減)為基礎治療。治療組予以紫草軟膏均勻涂擦于面部皮損處,聯(lián)合基礎治療；對照組予以氟芬那酸丁酯軟膏均勻涂擦于面部皮損處,聯(lián)合基礎治療。兩組同時治療4周,分別在治療當天及治療1周、2周及4周記錄患者瘙癢、紅斑等主、客觀臨床癥狀及相關的不良反應,對痊愈及顯效者進行隨訪1月。并進行統(tǒng)計分析,評價療效及復發(fā)情況。結果：經(jīng)4周臨床觀察顯示：完成臨床研究病例共83例,治療組43例,對照組40例。(1)治療組總有效率為86.1%；對照組總有效率為90.0%；兩組總療效經(jīng)統(tǒng)計學分析,P0.05,差異無統(tǒng)計學意義。(2)治療2周,兩組總積分差值比較,P0.05,差異有統(tǒng)計學意義。(3)兩組各癥狀積分差值比較,在干燥脫屑、緊繃不適方面,P0.05,差異有統(tǒng)計學意義；在紅斑、丘疹、腫脹、瘙癢、灼熱方面,P均0.05,差異無統(tǒng)計學意義。(4)治療組復發(fā)率為20.0%,對照組為47.8%,兩組復發(fā)率比較P0.05,差異有統(tǒng)計學意義。結論：(1)治療組總療效與對照組沒有區(qū)別;(2)在緩解皮膚干燥脫屑、緊繃不適感方面治療組明顯優(yōu)于對照組；(3)對照組治療面部皮炎起效比治療組快,但是遠期療效觀察發(fā)現(xiàn)治療組在降低復發(fā)率方面優(yōu)于對照組。
[Abstract]:Objective: in recent years, with the improvement of people's living standard, the rapid development of modern industrial technology, the worsening of food and environmental pollution, and the abuse of hormones and cosmetics, facial dermatitis is a kind of capacitive disease. Its incidence is increasing year by year. Its pathogenesis is not completely clear, but how to effectively cure facial lesions, achieve a good quality of life of patients, recovery of patients' physical and mental health is an important subject to be resolved in dermatology clinic. The purpose of this study was to compare the clinical effects and mechanism of oral simplified Xiaofeng Powder combined with Shikchow ointment and flurfenac butyrate ointment in the treatment of facial dermatitis. Methods: 88 subjects who met the inclusion criteria were randomly divided into 2 groups with 44 cases in each group. Both groups were treated with oral Chinese medicine (simplified Xiaofeng Powder plus or minus) as the basic treatment. The treatment group was evenly applied to the facial lesions and combined with basic treatment, while the control group was given flufenac butyrate ointment evenly applied to the facial lesions, combined with basic treatment. Patients with itching, erythema and other objective clinical symptoms and related adverse reactions were recorded on the day of treatment and 1 week, 2 weeks and 4 weeks of treatment respectively. The patients were followed up for 1 month. Statistical analysis was carried out to evaluate the curative effect and recurrence. Results: after 4 weeks of clinical observation, 83 cases were completed, 43 cases in the treatment group and 40 cases in the control group. (1) the total effective rate of the treatment group was 86.1, the total effective rate of the control group was 90.0%, and the total effective rate of the control group was 90.0%. There was no significant difference in the total curative effect between the two groups by statistical analysis (P 0.05). (2) after 2 weeks of treatment, the difference between the two groups was statistically significant (P 0.05). (3) the difference between the two groups was statistically significant. There was no significant difference in the aspects of erythema, papules, swelling, pruritus and burning (P 0.05). (4) the recurrence rate was 20.0% in the treatment group and 47.8% in the control group, and the difference was significant between the two groups (P 0.05). Conclusion: (1) the total curative effect of the treatment group is not different from that of the control group, (2) the treatment group is superior to the control group in relieving the dry skin desquamation and tense discomfort, (3) the treatment of facial dermatitis in the control group is faster than that in the treatment group. But long-term observation showed that the treatment group was superior to the control group in reducing recurrence rate.
【學位授予單位】：成都中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R275.9

【參考文獻】

相關期刊論文 前10條

1 葉招澆;閻瀾;李洪嬌;姜遠英;曹永兵;;中藥地榆的藥理作用及臨床應用研究進展[J];藥學服務與研究;2015年01期

2 張小靜;;面部皮炎的中醫(yī)治療[J];中醫(yī)研究;2012年10期

3 萬英;艾儒棣;;艾儒棣教授治療再發(fā)性皮炎經(jīng)驗[J];光明中醫(yī);2012年05期

4 陳俊杰;黃旭騰;王阿賓;;除濕止癢軟膏聯(lián)合皮炎擦劑治療顏面再發(fā)性皮炎療效觀察[J];實用中醫(yī)藥雜志;2011年09期

5 周永安;仵寧;;復發(fā)甘草酸苷膠囊治療女性顏面再發(fā)性皮炎療效觀察[J];中國美容醫(yī)學;2011年08期

6 陳彩霞;王鳳軒;;紫草生肌膏治療慢性皮膚潰瘍40例[J];中醫(yī)外治雜志;2010年06期

7 郭雯;郭建輝;趙麗;劉玉華;劉建;;復方甘草酸苷聯(lián)合涼血脫敏湯治療顏面再發(fā)性皮炎60例[J];中國中西醫(yī)結合皮膚性病學雜志;2010年05期

8 王家璧;劉躍華;;氟芬那酸丁酯軟膏在中國8年臨床研究回顧[J];中國皮膚性病學雜志;2010年08期

9 徐佳;曲惠卿;;針灸加穴位注射治療顏面再發(fā)性皮炎30例[J];南京中醫(yī)藥大學學報;2009年06期

10 何黎;溫海;徐麗敏;李利;楊春俊;涂穎;李娜;起玨;朱紅梅;周愛民;李虹;尹斌;蔣獻;劉盛秀;林達;;含馬齒莧及甘草提取物護膚品對敏感性皮膚輔助治療作用的臨床觀察[J];臨床皮膚科雜志;2009年06期

，

本文編號：2137206