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  本文選題：補腎降壓方 + 補腎益心片　； 參考：《廣州中醫(yī)藥大學》2016年碩士論文

【摘要】：目的：高血壓的治療目標是包括降壓在內(nèi)的靶器官保護、總體心血管風險降低以及生活質(zhì)量的提高。本研究旨在通過探討補腎法(補腎降壓方與補腎益心片)治療輕中度高血壓患者降壓療效、中醫(yī)證候及病人生活質(zhì)量改善情況,總結(jié)臨床經(jīng)驗,為中醫(yī)臨床辨治高血壓進一步提供有益的依據(jù)。方法：本研究擬采用前瞻性隨機對照的臨床研究方法,根據(jù)《中藥新藥臨床研究指導原則》,納入臨床上診斷為腎虛型高血壓患者100例。將患者隨機分成兩組,其中治療組50例和對照組50例。治療組予基礎西藥苯磺酸氨氯地平片1片QD降壓加用補腎降壓方與補腎益心片治療；對照組予基礎西藥苯磺酸氨氯地平片1片QD降壓,療程觀察為3個月。然后觀察并統(tǒng)計評估治療前后患者血壓、中醫(yī)證侯評分、病人生理狀況、工作狀態(tài)、睡眠、生活質(zhì)量等臨床療效。結(jié)果：臨床研究表明,兩組均具有良好的降壓效果,降壓總有效率(治療組VS對照組：95% VS 90%)；24h動態(tài)血壓療效觀察：治療前后兩組谷峰比及平滑指數(shù)組內(nèi)比較均具有統(tǒng)計學顯著性差異,兩組治療前后谷峰比與平滑指數(shù)組間差值比較均具有統(tǒng)計學顯著差異(p0.01),治療組優(yōu)于對照組；生活質(zhì)量改善方面,治療前后兩組多項指標均有改善,但治療組明顯優(yōu)于對照組指標。進一步表明對于腎虛型高血壓患者,在常規(guī)運用苯磺酸氨氯地平片進行降壓的同時,使用中醫(yī)藥補腎降壓方與補腎益心片治療進一步提高了單純使用西藥的療效。結(jié)論：在常規(guī)苯磺酸氨氯地平片降壓治療的基礎上,并給予補腎降壓方與補腎益心片中醫(yī)辨證治療,可進一步平穩(wěn)控制血壓,改善患者生活質(zhì)量,如軀體化狀況、生理癥狀、工作狀態(tài)、睡眠改善等。同時,也為中醫(yī)運用湯劑與片劑聯(lián)合辨證論治高血壓病提供了實用的方法和依據(jù)。
[Abstract]:Objective: the aim of treatment for hypertension is to protect target organs including hypotension, reduce overall cardiovascular risk and improve quality of life. The purpose of this study was to summarize the clinical experience of Bushen Jiangya decoction and Bushen Yixin tablet in the treatment of patients with mild and moderate hypertension by exploring the antihypertensive effect, TCM syndromes and the improvement of patients' quality of life. To provide a useful basis for the clinical treatment of hypertension. Methods: a prospective randomized controlled clinical study was carried out in 100 cases of hypertension with kidney deficiency according to the guiding principles of New Chinese Medicine Clinical Research. Patients were randomly divided into two groups: treatment group (n = 50) and control group (n = 50). The treatment group was treated with basic western medicine amlodipine benzenesulfonic acid (QD) 1 tablet QD combined with Bushen Jiangya decoction and Bushen Yixin tablet while the control group was treated with basic western medicine amlodipine benzenesulfonic acid 1 tablet QD and the course of treatment was observed for 3 months. Then observe and evaluate the clinical effect of blood pressure, TCM syndrome score, patient's physiological status, working state, sleep, quality of life before and after treatment. Results: the clinical study showed that both groups had good antihypertensive effect and the total effective rate was 90% (vs control group: 95% vs 90%). Observation of 24-hour ambulatory blood pressure: there were significant differences between the two groups before and after treatment. The difference between the two groups before and after treatment was statistically significant (p0.01), the treatment group was better than the control group, the improvement of quality of life, the two groups before and after treatment of a number of indicators improved, But the treatment group was better than the control group. It is further indicated that the traditional use of amlodipine benzenesulfonic acid tablets for lowering blood pressure, the use of traditional Chinese medicine Bushen Jiangya prescription and Bushen Yixin tablet to further improve the efficacy of the use of western medicine. Conclusion: on the basis of antihypertensive therapy of amlodipine benzenesulfonic acid tablets and traditional Chinese medicine differentiation treatment of Bushen Jiangya decoction and Bushen Yixin tablet, the blood pressure can be controlled steadily and the quality of life of patients can be improved, such as somatization and physiological symptoms. Work status, sleep improvement, etc. At the same time, it also provides the practical method and basis for the treatment of hypertension with decoction and tablet combined with syndrome differentiation.
【學位授予單位】：廣州中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

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