本文選題：急性重度一氧化碳中毒 + 大株紅景天注射液��； 參考：《中醫(yī)雜志》2017年16期

【摘要】：目的探討大株紅景天注射液對(duì)急性重度一氧化碳中毒患者心肌損傷的影響及可能作用機(jī)制。方法104例急性重度一氧化碳中毒患者隨機(jī)分成對(duì)照組和治療組各52例,對(duì)照組給予西醫(yī)常規(guī)治療,治療組在常規(guī)治療基礎(chǔ)上加用大株紅景天注射液10 ml靜脈滴注,每日1次,治療2周。兩組于治療前及治療6 h、14天檢測(cè)血清心型脂肪酸結(jié)合蛋白(H-FABP)、肌紅蛋白(Myo)變化,于治療前后檢測(cè)患者血一氧化氮(NO)、一氧化氮合酶(NOS)及誘導(dǎo)型一氧化氮合酶(iNOS)水平,記錄簡(jiǎn)易精神狀態(tài)檢查量表(MMSE)評(píng)分和左心室射血分?jǐn)?shù)(LVEF)水平變化,觀(guān)察主要心臟不良事件發(fā)生率。采用Pearson相關(guān)檢驗(yàn)分析患者入院時(shí)血清H-FABP與LVEF的相關(guān)性。結(jié)果兩組患者治療6 h時(shí)血清H-FABP和Myo水平較治療前升高,但治療組低于對(duì)照組(P0.05),兩組治療14天時(shí)血清H-FABP和Myo水平均較本組治療前及治療6 h降低(P0.05)。治療后兩組血NO、NOS、iNOS水平較治療前降低(P0.05),LVEF水平和MMSE評(píng)分較治療前升高,治療后MMSE評(píng)分治療組優(yōu)于對(duì)照組(P0.05)。治療組主要心臟不良事件發(fā)生率明顯低于對(duì)照組(P0.05)。104例患者入院時(shí)血清H-FABP水平與其LVEF呈負(fù)相關(guān)(r=-0.235,P=0.017)。結(jié)論大株紅景天注射液能減少急性重度一氧化碳中毒心肌損傷及心臟不良事件的發(fā)生,改善心功能,可能與降低血H-FABP、Myo、NO、NOS、iNOS水平有關(guān)。
[Abstract]:Objective to investigate the effect and possible mechanism of large strain Rhodiola injection on myocardial injury in patients with acute severe carbon monoxide poisoning. Methods 104 patients with acute severe carbon monoxide poisoning were randomly divided into control group (n = 52) and treatment group (n = 52). The control group was treated with routine western medicine. Treatment 2 weeks. Serum levels of cardiac fatty acid binding protein (H-FABP), myoglobin (Myo), nitric oxide (no), nitric oxide synthase (NOS) and inducible nitric oxide synthase (iNOS) were measured before and after treatment in both groups. The changes of MMSE score and left ventricular ejection fraction (LVEF) were recorded to observe the incidence of major adverse cardiac events. The correlation between serum H-FABP and LVEF was analyzed by Pearson correlation test. Results the levels of serum H-FABP and Myo in the two groups increased at 6 h after treatment, but were lower in the treatment group than in the control group (P0.05), and the levels of H-FABP and Myo in the two groups decreased at 14 days after treatment (P0.05). After treatment, the levels of NOSN iNOS in the two groups were lower than those before treatment (P0.05) and the scores of LVEF and MMSE were higher in the treatment group than in the control group (P0.05). The incidence of major adverse cardiac events in the treatment group was significantly lower than that in the control group (P0.05). There was a negative correlation between the serum H-FABP level and LVEF in 104 patients (r = 0.235). Conclusion large strain Rhodiola injection can reduce myocardial injury and adverse cardiac events in acute severe carbon monoxide poisoning, and improve cardiac function, which may be related to the decrease of serum H-FABP- Myotropium novo NOSINOS level in patients with acute carbon monoxide poisoning.
【作者單位】： 河北醫(yī)科大學(xué)附屬哈勵(lì)遜國(guó)際和平醫(yī)院;
【基金】：衡水市科學(xué)技術(shù)研究與發(fā)展計(jì)劃項(xiàng)目(201401Z)
【分類(lèi)號(hào)】：R259

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 沈國(guó)滿(mǎn);樊世明;田香山;;大株紅景天膠囊對(duì)不穩(wěn)定性心絞痛患者血栓形成的影響[J];中國(guó)實(shí)驗(yàn)方劑學(xué)雜志;2014年16期

2 曹鴻濵;傅薇;張?jiān)评?王曉煥;;大株紅景天對(duì)老年冠心病合并2型糖尿病患者血液流變學(xué)的影響[J];中國(guó)老年保健醫(yī)學(xué);2014年04期

3 劉志立;;大株紅景天治療冠心病心絞痛臨床觀(guān)察[J];醫(yī)藥論壇雜志;2011年23期

4 趙志中;;大株紅景天注射液治療急性腦梗死60例療效觀(guān)察[J];中國(guó)實(shí)用神經(jīng)疾病雜志;2011年16期

5 劉云霞;蒙瑞;;大株紅景天注射液治療心絞痛療效觀(guān)察[J];求醫(yī)問(wèn)藥(下半月);2012年10期

6 丁寶玉;周琳;馬蓉;;大株紅景天注射液治療老年冠心病心絞痛臨床觀(guān)察[J];中國(guó)實(shí)用醫(yī)藥;2013年12期

7 唐彬;王志祥;羅慶文;李云華;;大株紅景天注射液治療穩(wěn)定型心絞痛療效觀(guān)察[J];云南中醫(yī)中藥雜志;2013年03期

8 張由建;;大株紅景天注射液治療不穩(wěn)定心絞痛患者臨床療效觀(guān)察[J];河南醫(yī)學(xué)研究;2013年03期

9 張秀蘭;劉續(xù)芳;;高效液相色譜法(HPLC)測(cè)定藏藥大株紅景天飲片中紅景天苷含量[J];中國(guó)民族醫(yī)藥雜志;2012年12期

10 羅浩;楊先娥;葉婧;李艷萍;鄭僑克;;大株紅景天注射液對(duì)急性冠脈綜合征病人血清IL-6及MCP-1水平的影響[J];中成藥;2013年10期

相關(guān)碩士學(xué)位論文 前2條

1 程小峰;大株紅景天注射液應(yīng)用于肺癌化療患者的臨床研究[D];福建中醫(yī)藥大學(xué);2013年

2 臧書(shū)偉;大株紅景天注射液對(duì)缺血心肌血運(yùn)重建后MIRI保護(hù)作用的研究[D];南京中醫(yī)藥大學(xué);2013年

，

本文編號(hào)：2106867