發(fā)布時間：2018-07-03 04:38

  本文選題：原發(fā)性膽汁性膽管炎 + 茵陳玉露飲��； 參考：《南京中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:觀察茵陳玉露飲聯(lián)合熊去氧膽酸治療原發(fā)性膽汁性膽管炎(primary biliary cirrhosis,PBC)的臨床療效并探討其組方原理。方法:病例來源于2015年3月—2016年12月期間就診于江蘇省中醫(yī)院感染科門診,且符合入選標(biāo)準(zhǔn)的56例原發(fā)性膽汁性膽管炎患者。將患者分為對照組和治療組各28例,對照組單獨使用熊去氧膽酸(Ursodeoxy cholic acide,UDCA),治療組在對照組的基礎(chǔ)上予茵陳玉露飲治療,3個月為1療程,共觀察2個療程。在治療前及治療3個月后、6個月后分別記錄兩組患者的癥狀體征、肝功能各項指標(biāo),并觀察不良反應(yīng)。采用SPSS19.0軟件進(jìn)行統(tǒng)計分析,設(shè)P0.05為差異有統(tǒng)計學(xué)意義。結(jié)果:(1)中醫(yī)證候比較:治療3個月后,兩組證候總積分比較,差異有統(tǒng)計學(xué)意義(P0.05);癥狀體征比較,僅脅痛有統(tǒng)計學(xué)意義(P0.05)。治療6個月后,兩組證候總積分比較,差異有顯著意義(P0.01);癥狀體征比較,在脅痛、乏力、瘙癢、口干、納差方面,差異有統(tǒng)計學(xué)意義(P0.05)。治療組中醫(yī)證候總有效率82.15%,優(yōu)于對照組46.43%,差異有統(tǒng)計學(xué)意義(P0.05)。(2)肝功能比較:治療3個月后,兩組病例的ALT、ALP、GGT、TBIL、DBIL與治療前相比均有統(tǒng)計學(xué)意義(P0.05);組間比較無統(tǒng)計學(xué)意義。治療6個月后,兩組病例的AST、ALT、ALP、GGT、TBIL、DBIL與治療前相比均有統(tǒng)計學(xué)意義(P0.05);組間比較AST、ALP有統(tǒng)計學(xué)意義(P0.05),說明治療組在AST、ALP上改善優(yōu)于對照組。結(jié)論:茵陳玉露飲聯(lián)合熊去氧膽酸能改善PBC患者的臨床癥狀,包括脅痛、乏力、瘙癢、口干、納差;并能改善患者的肝功能指標(biāo),尤其在AST、ALP方面有優(yōu)勢;且安全性良好,值得進(jìn)一步推廣研究。
[Abstract]:Objective: to observe the clinical effect of Yinchenyu Luyin combined with ursodeoxycholic acid in the treatment of (primary biliary cirrhosis PBC. Methods: from March 2015 to December 2016, 56 patients with primary biliary cholangitis were admitted to Jiangsu Provincial Hospital of traditional Chinese Medicine. The patients were divided into control group (n = 28) and treatment group (n = 28). The control group was treated with Ursodeoxy cholic acidecholic acid (UDCA) alone. The treatment group was treated with Yinchen Yulu decoction on the basis of the control group. The symptoms and signs, liver function and adverse reactions were recorded before and after treatment for 3 months and 6 months respectively. SPSS 19.0 software was used to carry out statistical analysis, set P0.05 as the difference was statistically significant. Results: (1) comparison of TCM syndromes: after 3 months of treatment, there was a significant difference between the two groups in the total score of syndromes (P0.05); symptoms and signs of comparison, only hypochondriac pain had statistical significance (P0.05). After 6 months of treatment, there was significant difference between the two groups in the total score of syndromes (P0.01); the comparison of symptoms and signs in hypochondriac pain, fatigue, pruritus, dry mouth, anorexia, the difference was statistically significant (P0.05). The total effective rate of TCM syndromes in the treatment group was 82.15, which was better than that in the control group (46.43). The difference was statistically significant (P0.05). (2). After 3 months of treatment, the two groups had statistical significance compared with those before treatment (P0.05). After 6 months of treatment, there were significant differences between the two groups (P0.05) in the treatment of ASTT ALP GGTT TILB DBIL and between the two groups (P0.05), indicating that the treatment group was better than the control group in the improvement of ASTT ALP. Conclusion: Yinchenyu Luyin combined with ursodeoxycholic acid can improve the clinical symptoms of PBC patients, including hypochondriac pain, fatigue, itching, dry mouth and poor anorexia, and can improve the liver function, especially in AST ALP, and has good safety. It is worth further popularizing research.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R259

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