本文選題：固本潤腸膏 + 脾腎陽虛��； 參考：《安徽中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的通過觀察固本潤腸膏對脾腎陽虛型便秘患者血管活性腸肽、P物質(zhì)的影響,將其觀察指標(biāo)、副作用及不良反應(yīng)等方面與服用琥珀酸普魯卡必利的患者進(jìn)行比較,了解其在以上各方面優(yōu)于后者之處,為固本潤腸膏在臨床廣泛應(yīng)用中提供數(shù)字化的客觀的科學(xué)的支撐,以提高該病患者的治療效果。方法用軟件制作隨機(jī)碼將100例符合條件并且已納入臨床實(shí)驗(yàn)研究的患者隨機(jī)的分為治療組(口服固本潤腸膏,溫服,早中晚各20毫升)和對照組(口服琥珀酸普魯卡必利,1毫克每晚)各50例。比較兩組患者在年齡大小、病程長短、性別比例、病情輕重程度等方面的差異,得出P值均大于0.05,說明兩組患者在以上各方面的差異均沒有明顯的統(tǒng)計學(xué)意義。共設(shè)3個治療階段,每一治療階段均設(shè)為28天。了解并記錄標(biāo)本病例各個觀察指標(biāo),并在三個階段結(jié)束后28天觀察患者是否出現(xiàn)病情復(fù)發(fā)的情況。臨床指標(biāo):記錄所有標(biāo)本病例服藥前一周及每一療程最后一周的排便次數(shù)以及單次排便的時間;記錄患者開始服藥前一天及療程結(jié)束后一天的中醫(yī)證候積分。實(shí)驗(yàn)室指標(biāo):全部受檢者自開始服藥前1日及每一療程結(jié)束后1日晨空腹抽取肘靜脈血6ml(用肝素鈉抗凝),用干凈試管收集血液,所有血標(biāo)本以3000r/min離心15分鐘,吸取血清放置于-80℃冰箱內(nèi)保存,待治療結(jié)束并收集齊所有血清標(biāo)本,再統(tǒng)一檢測并記錄實(shí)驗(yàn)得出VIP值、SP值。影像學(xué)指標(biāo):結(jié)腸傳輸實(shí)驗(yàn):服藥前檢查結(jié)腸傳輸實(shí)驗(yàn),停藥后3天復(fù)查,觀察治療后結(jié)腸傳輸改善率。標(biāo)本病例各個觀察指標(biāo)的結(jié)果均采用兩獨(dú)立樣本的t檢驗(yàn)進(jìn)行比較,P值小于0.05說明指標(biāo)間的差異具有統(tǒng)計學(xué)意義。標(biāo)本病例各項(xiàng)觀察指標(biāo)及基本信息的記錄與比較,均采用SPASS17.0統(tǒng)計軟件包。結(jié)果比較治療組和對照組標(biāo)本病例的各項(xiàng)觀察指標(biāo),VIP、SP、單周排便次數(shù)、單次排便時間、結(jié)腸傳輸實(shí)驗(yàn)、中醫(yī)證候積分、及復(fù)發(fā)率方面,P值均小于0.05或0.01,且在治療過程中,標(biāo)本病例均未出現(xiàn)藥物不良反應(yīng)。結(jié)論固本潤腸膏在治療脾腎陽虛型便秘方面較琥珀酸普蘆卡必利有著明顯的優(yōu)勢,對脾腎陽虛型便秘患者的各項(xiàng)觀察指標(biāo)均有著明顯的改善。實(shí)驗(yàn)結(jié)果顯示,固本潤腸膏治療脾腎陽虛型便秘不僅療效好,且副作用及復(fù)發(fā)率低,適合在臨床上廣泛應(yīng)用于該類型便秘患者。
[Abstract]:Objective to observe the effect of Guben Runchang ointment on vasoactive intestinal peptide substance P in patients with constipation with deficiency of spleen and kidney yang, and compare its observation index, side effects and adverse reactions with those of patients taking prucapride succinate. To understand the advantages of Guben Runchang ointment in all aspects above, to provide digital and objective scientific support for the wide application of Guben Runchang ointment in clinic, so as to improve the therapeutic effect of Guben Runchang ointment. Methods 100 patients who met the criteria and were included in the clinical trial were randomly divided into treatment group (oral Guben Runchang ointment, warm suit). Early, mid-evening, 20 ml) and control group (oral 1 mg of prapiride succinate, 50 cases per night). The difference of age, duration of disease, sex ratio, severity of disease and so on were compared between the two groups. The P value was more than 0.05, which indicated that there was no significant difference between the two groups in the above aspects. There were 3 treatment stages, each of which was set up for 28 days. To understand and record the observed indexes of the specimen and observe whether the patient has relapse 28 days after the end of the three stages. Clinical indicators: the number of defecation and the time of single defecation were recorded one week before taking the medicine and the last week of each course of treatment, and the TCM syndromes scores of the patients before and after the course of treatment were recorded. Laboratory indicators: all the subjects collected 6ml (anticoagulant with heparin sodium) from the elbow vein on an empty stomach 1 day before and after each course of treatment, and collected the blood with a clean tube. All blood samples were centrifuged with 3000r/min for 15 minutes. The collected serum was stored in the refrigerator at -80 鈩，

本文編號：2053060