本文選題：三參四黃降糖膠囊 + 氣陰兩虛夾瘀型��； 參考：《湖北民族學(xué)院》2016年碩士論文

【摘要】：目的:客觀評(píng)價(jià)中藥復(fù)方制劑三參四黃降糖膠囊對(duì)氣陰兩虛夾瘀型2型糖尿病的臨床療效。方法:本課題選取80例符合納入標(biāo)準(zhǔn)的建始縣中醫(yī)院門(mén)診及住院2型糖尿病患者,并隨機(jī)分為觀察組和對(duì)照組,每組各40例。所選患者治療療程中均進(jìn)行糖尿病宣教,并配合飲食、運(yùn)動(dòng)療法。對(duì)照組給予人胰島素注射,初始劑量0.44U/(kg d),餐前30min皮下注射,每日2次,早晚餐前按1:1比例分配,并根據(jù)空腹血糖和餐后2h血糖水平調(diào)整胰島素劑量,1個(gè)月為1個(gè)療程,連續(xù)治療3個(gè)療程評(píng)定療效。觀察組在對(duì)照組的基礎(chǔ)上加用三參四黃降糖膠囊(由建始縣中醫(yī)院生產(chǎn)并經(jīng)恩施州藥監(jiān)局批準(zhǔn),批準(zhǔn)文號(hào)ZC2004003),每次4粒,每日3次口服。觀察兩組患者治療前后中醫(yī)臨床癥狀、空腹血糖(FPG)、餐后2h血糖(2hPBG)、糖化血紅蛋白(HbAlc)及安全性指標(biāo)方面的情況。兩組患者在性別、年齡、病程、治療前各觀察指標(biāo)方面無(wú)顯著性差異,具有可比性。結(jié)果:兩組患者總療效比較,觀察組總有效率為90.32%,對(duì)照組總有效率為78.79%,經(jīng)統(tǒng)計(jì)學(xué)分析得出,P0.05,差異具有顯著性,說(shuō)明觀察組總療效優(yōu)于對(duì)照組。在中醫(yī)證候方面,觀察組與對(duì)照組治療后組間比較,P0.05,差異具有顯著性,觀察組優(yōu)于對(duì)照組。在空腹血糖、餐后2小時(shí)血糖、糖化血紅蛋白方面,觀察組與對(duì)照組治療后組間比較,P0.05,差異具有顯著性,觀察組優(yōu)于對(duì)照組。兩組療程期間未發(fā)生明顯的藥物不良反應(yīng)。結(jié)論:兩組方法對(duì)2型糖尿病(氣陰兩虛夾瘀型)均有較好的療效。但三參四黃降糖膠囊聯(lián)合人胰島素治療氣陰兩虛夾瘀型2型糖尿病的療效明顯優(yōu)于單純西藥組,且具有良好的安全性,值得進(jìn)一步推廣應(yīng)用。
[Abstract]:Objective: to evaluate the clinical effect of Sanshen Sihuang Jiangtang capsule, a compound preparation of traditional Chinese medicine, on type 2 diabetes mellitus with deficiency of qi and yin. Methods: 80 patients with type 2 diabetes mellitus were randomly divided into observation group and control group with 40 cases in each group. The selected patients were treated with diabetes education, diet and exercise therapy. The control group was injected with human insulin. The initial dose of 0.44 U / (kg d), 30min was injected subcutaneously twice a day. The morning and evening preprandial 30min was distributed according to 1:1 ratio. The insulin dosage was adjusted according to fasting blood glucose and 2 h postprandial blood glucose level. One month was a course of treatment. Three consecutive courses of treatment were used to evaluate the efficacy. The observation group was treated with Sanshen Sihuang Jiangtang capsule on the basis of the control group (produced by Jianshixian traditional Chinese Medicine Hospital and approved by the Bureau of Drug Supervision of Enshi Prefecture, approved ZC2004003), 4 capsules each time, three times a day. The clinical symptoms, fasting blood glucose (FPG), postprandial blood glucose (2 h PBG), glycosylated hemoglobin (HbAlc) and safety indexes were observed before and after treatment. There were no significant differences in sex, age, course of disease and observed indexes before treatment between the two groups. Results: the total effective rate was 90.32 in the observation group and 78.79 in the control group. The statistical analysis showed that the total effective rate of the observation group was better than that of the control group. In TCM syndromes, the observation group was better than the control group in comparison with the control group after treatment (P 0.05), there was a significant difference between the observation group and the control group. There were significant differences in fasting blood glucose, 2 hours postprandial blood glucose and glycosylated hemoglobin between the observation group and the control group after treatment (P 0.05), and the observation group was superior to the control group. No significant adverse drug reactions occurred during the course of treatment in the two groups. Conclusion: the two methods have better curative effect on type 2 diabetes mellitus. But Sanshen Sihuang Jiangtang capsule combined with human insulin in the treatment of type 2 diabetes mellitus with deficiency of qi and yin and deficiency of blood stasis was better than that of western medicine group, and had good safety, which was worthy of further popularization and application.
【學(xué)位授予單位】：湖北民族學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R259

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