本文選題：腎精 + 安神定志�。� 參考：《中醫(yī)雜志》2017年13期

【摘要】：中醫(yī)學認為腎藏精,在志為恐,腎精是腎發(fā)揮調節(jié)情志功能的物質基礎和根本保證。當機體處于驚恐應激時,腎精不足既能易化恐懼記憶的形成,又能鞏固恐懼記憶使之難以消退;而恐懼記憶的固化又使患者長期處于高度恐懼或極易恐懼的狀態(tài),進一步耗損腎精。前額葉皮質-杏仁核-海馬是與恐懼記憶形成和消退密切相關的神經(jīng)回路,補腎方藥對恐懼記憶形成和消退具有重要的調節(jié)作用。基于此提出"以前額葉皮質-杏仁核-海馬為作用通路,腎精可通過影響與恐懼記憶密切相關的應激激素(神經(jīng)肽)和神經(jīng)遞質及其受體的合成釋放與表達,進而整體性地調控激素與遞質系統(tǒng)間的相互作用,發(fā)揮其安神定志促進恐懼消退的效應"的科學假說,并從動物模型、激素與神經(jīng)遞質以及表觀遺傳學機制等方面對今后的研究思路進行初步探討。
[Abstract]:Traditional Chinese medicine holds that the kidney contains essence and the kidney essence is the material basis and fundamental guarantee of regulating the function of emotion. When the body is in panic stress, deficiency of kidney essence can not only facilitate the formation of fear memory, but also consolidate fear memory and make it difficult to fade away; and the solidification of fear memory makes patients in a state of high fear or high risk of fear for a long time. Further depletion of kidney essence. Prefrontal cortex amygdala and hippocampus are the neural circuits closely related to the formation and regression of fear memory. The prescription of tonifying kidney plays an important role in regulating the formation and regression of fear memory. Based on this, it is suggested that "prefrontal cortex, amygdala and hippocampus play an important role in the release and expression of stress hormones (neuropeptides), neurotransmitters and their receptors, which are closely related to fear memory." In turn, the scientific hypothesis of regulating the interaction between hormones and transmitters, and exerting its calming effect on fear regression, "and from animal models, Hormone, neurotransmitter and epigenetic mechanism were discussed in the future.
【作者單位】： 廣州中醫(yī)藥大學基礎醫(yī)學院;
【基金】：國家自然科學基金(30873207) 廣東省自然科學基金(2016A030313648)
【分類號】：R277.7
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本文編號：2049136