本文選題：慢性緊張型頭痛 + 肝郁化火　； 參考：《廣西中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:通過觀察丹梔逍遙散化裁方對慢性緊張型頭痛(肝郁化火證)的臨床癥狀及中醫(yī)癥候積分等的影響,評價其療效及安全性,為其臨床運用提供依據(jù)。方法:研究從廣西玉林市中醫(yī)院門診選取64例符合西醫(yī)診斷為慢性緊張型頭痛,中醫(yī)診斷為頭痛病(肝郁化火證)的患者,采用完全隨機數(shù)字表法,將患者平均分為對照組32例,使用單純西藥治療(鹽酸阿米替林片);治療組32例,在對照組藥物的基礎(chǔ)上聯(lián)合使用丹梔逍遙散化裁方治療。兩組患者均連續(xù)服藥8周,計為一個療程。分別觀察兩組患者慢性緊張型頭痛積分、中醫(yī)癥候積分及安全性指標(biāo)的變化情況,并對所得數(shù)據(jù)運用SPSS統(tǒng)計軟件進(jìn)行統(tǒng)計分析比較。結(jié)果:(1)慢性緊張型頭痛療效:治療組總有效率為93.33%;對照組總有效率為80.00%。兩組療效相比有顯著性差異(P0.05);(2)中醫(yī)癥候療效:治療組總有效率為90%;對照組總有效率為53.34%。兩組療效相比有顯著性差異(P0.01);(3)慢性緊張型頭痛積分:治療組經(jīng)治療后慢性緊張型頭痛總積分及總積分差值與對照組相比,具有非常顯著性差異(P0.01)。治療組治療前后各項指標(biāo)積分差異均具有顯著性(P0.01),且治療后頭痛強度、時間、次數(shù)積分與對照組相比差異有統(tǒng)計學(xué)意義(P0.05),而伴隨癥狀無明顯差異(P0.05);(4)中醫(yī)癥候積分:治療組經(jīng)治療后中醫(yī)癥候積分及總積分差值與對照組相比,差異具有顯著性(P0.05);(5)安全性分析:治療前后,所有患者血常規(guī)、肝腎功能、心電圖檢查均無明顯異常變化,并未出現(xiàn)明顯不良反應(yīng)。結(jié)論:(1)丹梔逍遙散化裁方對慢性緊張型頭痛(肝郁化火證)的各項中西醫(yī)臨床癥狀的改善明顯優(yōu)于對照組,具有良好的臨床治療效果。(2)丹梔逍遙散化裁方治療慢性緊張型頭痛(肝郁化火證)未出現(xiàn)明顯的不良反應(yīng)與毒副作用,安全性較好。
[Abstract]:Objective: to observe the effect of Danzhi Xiaoyao Sanhua recipe on the clinical symptoms and TCM syndromes of chronic tension headache (liver depression and fire syndrome), to evaluate its efficacy and safety, and to provide the basis for its clinical application. Methods: a total of 64 patients with chronic tension headache diagnosed by western medicine and headache by TCM (liver depression and fire syndrome) were selected from the outpatient department of Yulin traditional Chinese Medicine Hospital of Guangxi Province. The patients were divided into control group (n = 32) and control group (n = 32), which were treated with simple western medicine (amitriptyline hydrochloride tablets) and treatment group (n = 32) with Danzhi Xiaoyao Sanhua prescription on the basis of control group. The patients in both groups were treated continuously for 8 weeks as a course of treatment. The changes of chronic tension-type headache score, TCM symptom score and safety index were observed, and the data were analyzed and compared with SPSS software. Results: the total effective rate of chronic tension headache was 93.33 in the treatment group and 80.00in the control group. There was significant difference between the two groups in the curative effect of TCM symptom: the total effective rate of the treatment group was 90; the total effective rate of the control group was 53.34. There was significant difference in the curative effect between the two groups (P 0.01) the score of chronic tension headache: after treatment, the total score and the difference of total score of chronic tension headache in the treatment group were significantly different from those in the control group (P 0.01). In the treatment group, there were significant differences in the scores of each index before and after treatment, and the intensity and time of headache after treatment. Compared with the control group, the scores of times were significantly different from those of the control group (P 0.05), but there was no significant difference in the syndromes associated with the symptoms. (2) the TCM symptom score and the total integral difference between the treatment group and the control group were compared with those in the control group, and there was no significant difference between the treatment group and the control group. Before and after treatment, there were no obvious abnormal changes in blood routine, liver and kidney function, electrocardiogram, and no obvious adverse reactions. Conclusion the effect of Danzhi Xiaoyao Sanhua recipe on the clinical symptoms of chronic tension headache (liver depression and fire syndrome) is obviously better than that of the control group. It has good clinical effect. 2) Danzhi Xiaoyao Sanhua prescription has no obvious adverse reactions and side effects in the treatment of chronic tension headache (liver depression and fire syndrome), and the safety is good.
【學(xué)位授予單位】：廣西中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2016
【分類號】：R277.7

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