本文選題：穴位注射 + 中藥茶�。� 參考：《中華中醫(yī)藥雜志》2017年06期

【摘要】：目的:以中醫(yī)"治未病"的理念探討穴位注射和中藥茶延緩去勢(shì)雌性大鼠衰老的作用機(jī)制。方法:選取3月齡雌性SD大鼠156只,分為假手術(shù)組以及三大組群:次切組群、次全切組群和全切組群,每個(gè)組群里包含模型組、中藥茶組、穴位注射組和中藥茶+穴位注射組,每組12只。去勢(shì)造模成模后,各中藥茶組自由飲藥;各穴位注射組注射丹紅注射液。觀察各組大鼠血清中雌二醇(E_2)、卵泡刺激素(FSH)以及心臟組織中沉默信息調(diào)節(jié)因子2相關(guān)酶1(SIRT1)蛋白水平,以及子宮組織形態(tài)結(jié)構(gòu)的變化。結(jié)果:與假手術(shù)組比較,模型組大鼠血清中E_2和心臟組織中SIRT1蛋白含量顯著降低(P0.01),血清中FSH含量顯著升高(P0.01);與模型組比較,各治療組均能提高血清中E_2和心臟組織中SIRT1蛋白含量(P0.01),降低血清中FSH水平(P0.01);子宮組織形態(tài)顯示各治療組均能使子宮內(nèi)膜上皮增厚,使間質(zhì)致密、腺體增多、血管豐富。其中以次切組群中藥茶+穴位注射組治療效果最佳(P0.01)。結(jié)論:穴位注射和中藥茶對(duì)去勢(shì)大鼠有延緩衰老的功能,其機(jī)制可能是通過(guò)提高大鼠血清中雌激素以及組織中SIRT1蛋白的含量,降低血清中FSH水平,進(jìn)而發(fā)揮其抗衰老的作用。
[Abstract]:Objective: to explore the mechanism of acupoint injection and Chinese herbal tea in delaying the aging of ovariectomized female rats. Methods: 156 female Sprague-Dawley rats aged 3 months were divided into sham operation group and three groups: subtotal group, subtotal group and total group. Each group included model group, tea group, acupoint injection group and acupoint injection group. There were 12 rats in each group. After ovariectomized, each Chinese herbal tea group was free to drink and every acupoint injection group was injected with Dan Hong injection. The serum levels of estradiol, follicle stimulating hormone (FSHs) and silent signaling factor-2 related enzyme 1 sirt1 (sirt1) in serum of rats in each group were observed, and the changes of uterine structure were observed. Results: compared with the sham operation group, the serum EK2 and SIRT1 protein contents in the model group were significantly lower than those in the model group, while the FSH content in the serum was significantly increased in the model group, and compared with the model group, the content of FSH in the model group was significantly higher than that in the model group. Each treatment group could increase the content of EST1 protein in serum and heart tissue and decrease the level of FSH in serum P0.01.The uterine tissue morphology showed that the endometrial epithelium was thickened, interstitial dense, glands increased and blood vessels were abundant in each treatment group. Among them, the best treatment effect was P0.01in the group treated with Chinese herbal tea acupoint injection. Conclusion: Acupoint injection and traditional Chinese medicine tea can delay aging in ovariectomized rats. The mechanism may be to decrease the level of FSH by increasing the content of estrogen in serum and SIRT1 protein in tissue, and then to play its role in anti-aging of ovariectomized rats.
【作者單位】： 貴州醫(yī)科大學(xué);貴州醫(yī)科大學(xué)附屬醫(yī)院;
【基金】：貴州省科技合作計(jì)劃聯(lián)合基金項(xiàng)目(No.E-2015-11) 貴陽(yáng)市科技局科技計(jì)劃項(xiàng)目(No.J-2015-03)~~
【分類號(hào)】：R245

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