本文選題：數(shù)據(jù)挖掘 + 名老中醫(yī)經(jīng)驗��； 參考：《遼寧中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:采用數(shù)據(jù)挖掘技術(shù)分析李鐵教授中醫(yī)藥治療特發(fā)性血小板減少性紫癜(idiopathicthrombocy topenic purpura,ITP)的用藥特色,挖掘其臨證用藥規(guī)律及常用藥對組合,為中醫(yī)藥治療血小板減少性紫癜提供新的參考。材料與方法:收集大連市中西醫(yī)結(jié)合醫(yī)院李鐵專家門診2015年1月6日—2016年7月6日的血小板減少性紫癜的詳細(xì)資料,對所有的資料進(jìn)行整理。嚴(yán)格按照納入標(biāo)準(zhǔn)和排除標(biāo)準(zhǔn)進(jìn)行篩選,共選取符合標(biāo)準(zhǔn)病例39例,就診551診次,中藥處方551首。采用回顧性研究,設(shè)計實驗。用Excel軟件對患者性別、年齡、所用中藥(藥名、功效、歸經(jīng))、每方的中藥味數(shù)建立基本數(shù)據(jù)庫,并用Excel統(tǒng)計分析相應(yīng)的頻數(shù)、頻率。將藥物中出現(xiàn)頻率30%以上者作為常用藥,采用SPSS軟件作為數(shù)據(jù)挖掘庫,對常用藥物間的關(guān)聯(lián)進(jìn)行聚類分析。并對結(jié)果進(jìn)行分析討論。結(jié)果:1.選取血小板減少性紫癜患者39例,共就診551診次,用方551首。其中男性11人,女性28人,男女比為11:28,平均年齡為46歲。就診次數(shù)在10-20次最多,平均就診次數(shù)為14次。處方藥物平均數(shù)為16味。2.血小板減少性紫癜的癥候按就診頻次由高到低為:血熱妄行陰虛火旺氣不攝血濕熱內(nèi)蘊(yùn)瘀血阻滯。3.涉及單味中藥157味,取頻率大于30%的藥物為常用藥,篩選出常用中藥22味,用量在10-20g的藥物居多。4.按功效分類常用中藥,其中補(bǔ)益(氣、血、陰、陽)類藥物使用最頻,清熱藥次之,其余依次為止血藥、利水滲濕藥、理氣藥、解表藥。5.按經(jīng)絡(luò)歸屬分類可見歸經(jīng)涉及肝經(jīng)、脾經(jīng)的藥物居多,其余依次為心經(jīng)、胃經(jīng)、肺經(jīng)、腎經(jīng)、膽經(jīng)、膀胱經(jīng)。結(jié)論:1.血熱妄行、陰虛火旺、氣不攝血、濕熱內(nèi)蘊(yùn)、瘀血阻絡(luò)是血小板減少性紫癜的基本病機(jī),治以涼血止血、養(yǎng)陰涼血、益氣養(yǎng)陰、利濕解毒、散血止血為基本大法,并根據(jù)患者的具體情況及季節(jié)特色進(jìn)行加減運(yùn)用。2.用藥以補(bǔ)虛(氣、血、陰、陽)、清熱類中藥為主,符合血小板減少性紫癜相關(guān)辨證理論。3.血小板減少性紫癜的治療中,藥對的應(yīng)用尤為重要,統(tǒng)計李鐵教授在治療本病中的經(jīng)驗藥對的使用,對臨床用藥及隨癥加減有指導(dǎo)意義。
[Abstract]:Objective: to analyze the characteristics of professor Li Tie in the treatment of idiopathic thrombocytopenic topenic purpura (ITP) by using data mining technique, and to find out the law of clinical application and the combination of common drugs. To provide a new reference for the treatment of thrombocytopenic purpura with traditional Chinese medicine. Materials and methods: the detailed data of thrombocytopenic purpura from January 6, 2015 to July 6, 2016 in Li Tie expert outpatient clinic of Dalian Integrated Chinese and Western Medicine Hospital were collected and all the data were sorted out. According to the criteria of inclusion and exclusion, 39 cases were selected, 551 visits were made and 551 prescriptions of traditional Chinese medicine were selected. A retrospective study was used to design the experiment. The basic database of the patient's sex, age, used Chinese medicine (name of medicine, efficacy, the number of TCM flavor of each prescription) was established by Excel software, and the corresponding frequency and frequency were analyzed by Excel. Using SPSS software as data mining database, the association between common drugs was analyzed by cluster analysis. The results are analyzed and discussed. The result is 1: 1. Thirty-nine patients with thrombocytopenic purpura were selected and 551 visits were made. There were 11 males and 28 females, with a ratio of 11: 28, with an average age of 46 years. The number of visits was the highest in 10-20, and the average number of visits was 14. The average number of prescribed drugs was 16. 2. The symptoms of thrombocytopenic purpura according to the frequency of treatment from high to low: blood fever: Yin deficiency of fire and qi do not absorb blood dampness and heat stagnation blood stasis. 3. In this paper, 157 kinds of Chinese medicine with a frequency of more than 30% were used as common drugs, and 22 kinds of common Chinese medicines were screened out, and the drug dosage of 10 ~ 20 g was the most. 4. According to the efficacy classification of common Chinese medicine, among which tonifying (qi, blood, yin, Yang) drugs are used most frequently, the second is heat-clearing drugs, the rest are hemostatic drugs, water retention and dampness drugs, Qi regulating drugs, antitabular drugs. 5. According to the classification of meridian belonging to the meridian, we can see that the meridian involves the liver, the spleen meridian is the majority, the rest are heart channel, stomach channel, lung channel, kidney channel, gallbladder channel and bladder meridian. Conclusion 1. The basic mechanism of thrombocytopenic purpura is blood stasis, stagnation of collaterals and collaterals is the basic mechanism of thrombocytopenic purpura. The basic method of treatment is to cool blood and stop bleeding, nourish yin and cool blood, nourish qi and nourish yin, promote dampness and detoxify, and disperse blood to stop bleeding. And according to the specific conditions of patients and seasonal characteristics of the use of addition and subtraction. 2. Medication to tonify deficiency (qi, blood, yin, yang, heat-clearing traditional Chinese medicine, in line with thrombocytopenic purpura related syndrome differentiation theory. 3. In the treatment of thrombocytopenic purpura, the application of drug pair is particularly important. It is of guiding significance to use the empirical drug pair of professor Li Tie in the treatment of this disease.
【學(xué)位授予單位】：遼寧中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R249;R259

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 鄭迎春;李佳慧;;特發(fā)性血小板減少性紫癜診斷和治療效果探討[J];中國繼續(xù)醫(yī)學(xué)教育;2016年28期

2 孔晶;賈春暉;劉麗梅;徐君瑤;;特發(fā)性血小板減少性紫癜的中醫(yī)治療體會[J];中國繼續(xù)醫(yī)學(xué)教育;2016年22期

3 白峰巖;李戈;王剛;夏天;;特發(fā)性血小板減少性紫癜患兒白介素與細(xì)胞免疫的變化研究[J];中國現(xiàn)代醫(yī)學(xué)雜志;2016年13期

4 張?zhí)m華;王寶丹;;環(huán)孢素A用于治療小兒免疫性血小板減少性紫癜的效果分析[J];中國現(xiàn)代醫(yī)藥雜志;2016年05期

5 連靖娉;劉溯;王倩;;生地黃煎劑對膿毒癥患者血小板及凝血功能的影響[J];實用臨床醫(yī)藥雜志;2016年07期

6 朱翔;;劉永年教授應(yīng)用涼血散血法治療免疫性血小板減少癥的經(jīng)驗[J];中國中醫(yī)急癥;2015年10期

7 吳微華;;和營寧血湯聯(lián)合激素治療特發(fā)性血小板減少性紫癜療效觀察[J];新中醫(yī);2015年03期

8 李洪琴;陳波;江桂林;張靜靜;石煥玉;霍長亮;;中藥聯(lián)合重組白介素-11治療難治性特發(fā)性血小板減少性紫癜的臨床觀察和護(hù)理[J];實用臨床醫(yī)藥雜志;2014年22期

9 孫毅;高常柏;;辨證論治特發(fā)性血小板減少性紫癜[J];內(nèi)蒙古中醫(yī)藥;2014年28期

10 孫君艷;王偉;趙洪國;趙春亭;崔中光;李廣倫;;重組人血小板生成素治療原發(fā)免疫性血小板減少癥的療效察[J];血栓與止血學(xué);2014年02期

相關(guān)博士學(xué)位論文 前1條

1 劉珍;腹腔鏡脾切除術(shù)治療特發(fā)性血小板減少性紫癜的實驗和臨床研究[D];吉林大學(xué);2008年

相關(guān)碩士學(xué)位論文 前5條

1 何紅珍;裴氏參芪三黃湯治療氣不攝血型免疫性血小板減少性紫癜的臨床研究[D];甘肅中醫(yī)藥大學(xué);2016年

2 劉通強(qiáng);李鐵教授涼血法治療原發(fā)性血小板減少性紫癜的經(jīng)驗[D];遼寧中醫(yī)藥大學(xué);2015年

3 常冬梅;特發(fā)性血小板減少性紫癜中醫(yī)證候分布規(guī)律探討[D];河南中醫(yī)學(xué)院;2012年

4 努爾艾買提江·阿布來提;新疆紫草止血作用及機(jī)制的研究[D];新疆醫(yī)科大學(xué);2010年

5 朱霞;特發(fā)性血小板減少性紫癜發(fā)病相關(guān)的T細(xì)胞克隆基因譜系研究[D];鄭州大學(xué);2005年

，

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