本文選題：疏肝健脾湯 + 乙肝肝硬化　； 參考：《中藥材》2017年04期

【摘要】：目的:觀察疏肝健脾湯治療早期乙肝肝硬化肝氣郁結(jié)證患者的臨床療效及對(duì)患者血清IL-21、IL-22、IL-31及TGF-β1的影響。方法:將106例早期乙肝肝硬化肝氣郁結(jié)證患者隨機(jī)分為對(duì)照組和觀察組各53例。對(duì)照組給予恩替卡韋治療,觀察組在對(duì)照組的治療上加用疏肝健脾湯,所有患者均接受6個(gè)月的治療。檢測(cè)兩組患者治療前后血清丙氨酸氨基轉(zhuǎn)移酶(ALT)、門冬氨酸氨基轉(zhuǎn)移酶(AST)、總膽紅素(TBIL)、血清白蛋白(ALB)、透明質(zhì)酸(HA)、層粘連蛋白(LN)、Ⅲ型前膠原肽(PⅢNP)、Ⅳ型膠原(COLⅣ)、白介素21(IL-21)、白介素22(IL-22)、白介素31(IL-31)和轉(zhuǎn)化生長因子β1(TGF-β1)水平及肝纖維化模型Fibro Test(FT)參數(shù)。結(jié)果:兩組患者治療后血清ALT、AST、TBIL、HA、LN、PⅢNP、COLⅣ、IL-21、IL-22、IL-31及TGF-β1水平均顯著降低,ALB水平顯著升高,FT參數(shù)顯著降低(P0.05);且觀察組以上指標(biāo)改善均顯著優(yōu)于對(duì)照組(P0.05)。結(jié)論:疏肝健脾湯治療早期乙肝肝硬化肝氣郁結(jié)證的機(jī)制可能與降低患者血清炎癥因子IL-21、IL-22、IL-31及TGF-β1水平有關(guān)。
[Abstract]:Objective: to observe the clinical effect of Shugan Jianpi decoction (Shugan Jianpi decoction) in the treatment of liver qi stagnation syndrome of early hepatitis B cirrhosis and the effect of Shugan Jianpi decoction on serum IL-21 and TGF- 尾 1 levels. Methods: 106 patients with liver qi stagnation syndrome of early hepatitis B cirrhosis were randomly divided into control group (53 cases) and observation group (53 cases). The control group was treated with entecavir, the observation group was treated with Shugan Jianpi decoction, all the patients were treated for 6 months. Serum alanine aminotransferase (alt), aspartate aminotransferase (AST), total bilirubin (TBILL), serum albumin (Albumin), hyaluronic acid (HA), laminin (LN), type 鈪，

本文編號(hào)：2017139