本文選題：益心舒膠囊 + 老年不穩(wěn)定型心絞痛　； 參考：《南京中醫(yī)藥大學》2016年碩士論文

【摘要】：目的：探討“老年不穩(wěn)定型心絞痛證素及益心舒對其療效的臨床研究”,運用證素辨證學探討其證素特點,為中醫(yī)藥規(guī)范化治療提供參考。方法：將納入的符合研究標準的86例患者,隨機分為治療組和對照組,治療組44例,對照組42例。對照組給予常規(guī)治療,治療組在常規(guī)治療的基礎上加服益心舒膠囊,3粒／次,3次/日,療程為2周。觀察治療組和對照組的心絞痛癥狀、中醫(yī)證候、心電圖的改善情況,硝酸甘油、速效救心丸用量的變化情況及證素分析。結(jié)果：1.心絞痛療效方面：治療組總有效率為84.0%,對照組總有效率為76.1%,差異無統(tǒng)計學意義(P0.05)。2.心電圖療效方面：治療組心電圖好轉(zhuǎn)率為55.5%,對照組心電圖好轉(zhuǎn)率為47.6%,差異無統(tǒng)計學意(P0.05)。3.硝酸甘油等抗心絞痛藥物停減率方面：治療組為72.7%,對照組為66.6%,差異無統(tǒng)計學意義(P0.05)。4.中醫(yī)證候療效方面：治療組的總有效率為86.3%,對照組的總有效率為66.6%,差異具統(tǒng)計學意義這(P0.05)。5.證素分析結(jié)果：臨床診斷89.1%符合證素辨證學的規(guī)范證名,單一證素的貢獻度為心系證素氣虛證素陰虛證素,癥候辨證素量表癥狀頻數(shù)貢獻度的分布,基本符合高齡不穩(wěn)定型心絞痛(氣陰兩虛證)患者的臨床表現(xiàn)。結(jié)論：1.西醫(yī)常規(guī)治療聯(lián)合益心舒膠囊治療,在冠心病不穩(wěn)定型心絞痛患者的心絞痛療效、心電圖變化、硝酸甘油及速效救心丸減停率方面,與西醫(yī)常規(guī)治療無明顯差異。2.西醫(yī)常規(guī)治療聯(lián)合益心舒膠囊治療,在中醫(yī)療效方面優(yōu)于單用西醫(yī)常規(guī)治療。3.證素分析結(jié)果提示老年不穩(wěn)定型心絞痛(氣陰兩虛證)常見癥候為胸悶、心痛及胸痛,單一證素的貢獻度為心系證素氣虛證素陰虛證素,為臨床氣陰兩虛證的準確診斷提供了參考依據(jù)。
[Abstract]:Objective: to explore the clinical study on the therapeutic effect of senile unstable angina pectoris syndrome and Yixinshu syndrome, and to explore the characteristics of syndrome element by syndrome differentiation, and to provide reference for the standardized treatment of traditional Chinese medicine. Methods: 86 patients were randomly divided into treatment group (n = 44) and control group (n = 42). The control group was treated with routine therapy, the treatment group was treated with 3 capsules of Yixinshu capsule 3 times a day, the course of treatment was 2 weeks. The symptoms of angina pectoris, TCM syndromes, improvement of electrocardiogram, nitroglycerin, dosage of Quick-acting Jiuxin pills and syndromes were observed in the treatment group and the control group. The result is 1: 1. The total effective rate of angina pectoris was 84.0 in the treatment group and 76.1in the control group. The improvement rate of electrocardiogram in the treatment group was 55.5, and the improvement rate in the control group was 47.6. The difference was not significant (P 0.05). The stopping rate of anti-angina pectoris drugs such as nitroglycerin was 72.7 in the treatment group and 66.6 in the control group, the difference was not statistically significant (P 0.05). The curative effect of TCM syndrome: the total effective rate of the treatment group was 86.3, the total effective rate of the control group was 66.6, the difference was statistically significant (P 0.05). The results of analysis of syndromes were as follows: the clinical diagnosis was in accordance with the standard syndromes of syndrome differentiation, and the contribution of single syndrome factors was the distribution of symptom frequency of syndrome differentiation scale, the contribution degree of single syndromes was the element of yin deficiency of syndrome factors of heart system syndrome, and the distribution of symptom frequency of syndrome differentiation factor scale. Basically accord with the clinical manifestation of senile unstable angina pectoris (qi and yin deficiency syndrome). Conclusion 1. Western medicine combined with Yixinshu capsule in patients with coronary heart disease unstable angina pectoris curative effect, electrocardiogram changes, nitroglycerin and fast Jiuxin pills to reduce stop rate, there is no significant difference between the routine treatment of Western medicine. 2. Western medicine routine treatment combined with Yixinshu capsule treatment, in traditional Chinese medicine curative effect is superior to using western medicine routine treatment. 3. 3. The results of syndrome element analysis indicated that the common symptoms of senile unstable angina pectoris (qi and yin deficiency syndrome) were chest tightness, heart pain and chest pain, and the contribution degree of single syndrome element was that of heart system syndrome, qi deficiency syndrome and yin deficiency syndrome. It provides a reference for the accurate diagnosis of Qi and Yin deficiency syndrome.
【學位授予單位】：南京中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R259

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