發(fā)布時間：2018-06-10 18:52

  本文選題：黃芪建中湯 + 消化性潰瘍�。� 參考：《中國中醫(yī)急癥》2017年04期

【摘要】：目的評價黃芪建中湯治療消化性潰瘍的有效性。方法計算機(jī)檢索中國知網(wǎng)(CNKI)(1979~2016)、維普網(wǎng)(VIP)(1989~2016)和萬方數(shù)據(jù)知識服務(wù)平臺(WF)(1998~2016)。將臨床隨機(jī)對照試驗(RCTs)中所有關(guān)于黃芪建中湯與西藥治療進(jìn)行對照的文獻(xiàn)納入,依照Cochrane Review Handbook 5.3對納入的研究進(jìn)行的質(zhì)量評估由兩名評價者分別獨立完成。統(tǒng)計學(xué)分析采用軟件Rev Man5.3.5進(jìn)行。結(jié)果共18篇文獻(xiàn),2030例患者被納入。Meta分析結(jié)果示:1)臨床總有效率:黃芪建中湯配合三聯(lián)療法對照單用三聯(lián)療法,相對危險度[RR=1.11,95%CI(1.05,1.18)](P=0.0002);黃芪建中湯配合拉唑類藥物對照單用拉唑類藥物,相對危險度[RR=1.14,95%CI(1.06,1.22)](P=0.0005),上述差異均有統(tǒng)計學(xué)意義。2)臨床治愈率:黃芪建中湯配合三聯(lián)療法對照三聯(lián)療法,相對危險度[RR=1.28,95%CI(1.11,1.49)](P=0.0010),差異有統(tǒng)計學(xué)意義。3)復(fù)發(fā)率:黃芪建中湯對照拉唑類藥物,相對危險度[RR=0.33,95%CI(0.18,0.63)](P=0.0008);對照組在單用拉唑類藥物基礎(chǔ)上,根據(jù)Hp感染情況,酌情加用三聯(lián)療法,試驗組在該治療方案基礎(chǔ)上加用黃芪建中湯,相對危險度[RR=0.09,95%CI(0.01,0.66)](P=0.02);黃芪建中湯配合三聯(lián)療法對照單用三聯(lián)療法,相對危險度[RR=0.29,95%CI(0.15,0.57)](P=0.0003)。上述差異均有統(tǒng)計學(xué)意義。4)Hp清除率:黃芪建中湯單用對照單用拉唑類藥物療法,相對危險度[RR=2.60,95%CI(1.73,3.91)](P0.00001);黃芪建中湯配合拉唑類藥物對照單用拉唑類藥物,相對危險度[RR=1.10,95%CI(1.01,1.21)](P=0.04),上述差異均有統(tǒng)計學(xué)意義。結(jié)論黃芪建中湯治療消化性潰瘍相比單純使用西藥治療有一定優(yōu)勢,如提高臨床有效率、臨床治愈率、Hp清除率及降低復(fù)發(fā)率等。
[Abstract]:Objective to evaluate the efficacy of Huangqi Jianzhong decoction in the treatment of peptic ulcer. Methods to search for CNKI in China (1979) and VIPA (1989 ~ 2016) and WFN (1998 / 2016). All the literature in RCTs of clinical randomized controlled trial (RCTs) on the control of Astragalus Jianzhong decoction with western medicine treatment was included. The quality assessment of the included study according to Cochrane Review Handbook 5.3 was carried out independently by two evaluators. The statistical analysis was carried out by software Rev Man5.3.5. Results the total clinical effective rate of 2030 patients was included. Meta-analysis showed that the total effective rate was: Huangqi Jianzhong decoction combined with triple therapy, single triple therapy, relative risk [RRG1.1195CIX 1.055.1.18] Pu 0.0002N; Huangqi Jianzhong decoction combined with pyrazole drug control group was treated with single pyrazole drug, and the control group was treated with pyrazole alone, and the total effective rate was as follows: (1) the total effective rate was as follows: Huangqi Jianzhong decoction combined with triple therapy was used as control group, and the relative risk was 0.0002%. Relative risk [RRN 1.1495 CIQ 1.06C 1.22] Pao 0.0005, the above difference has statistical significance. 2) Clinical cure rate: Huangqi Jianzhong decoction combined with triple therapy control triple therapy, relative risk [RRRR1.28995 CI1.111.49] P0. 0010 (the difference is statistically significant. 3) recurrence rate: Huangqi Jianzhong decoction controls the use of pyrazole, and the relative risk (RRRN 1.28) 95CI1.111.49) P0. 0010 (P < 0. 3) recurrence rate: Huangqi Jianzhong decoction controls the use of pyrazole, and the relative risk (RRRN 1.28) 95CI1.111.49) the recurrence rate is statistically significant. Relative risk [RRX 0.33N 95] P0. 0008; in the control group, on the basis of single pyrazole drugs and according to HP infection, triple therapy was used as appropriate, and the experimental group was given Huangqi Jianzhong decoction on the basis of this treatment plan, and the control group was treated with Huangqi Jianzhong decoction, according to HP infection, and the control group was treated with Huangqi Jianzhong decoction, according to the situation of HP infection, and the control group was treated with Huangqi Jianzhong decoction. The relative risk [RRX 0.09 ~ 95 ~ 0.66] (P < 0.01); Huangqi Jianzhong decoction combined with triple therapy was treated with triple therapy alone, and the relative risk was [RRRN 0.2995 ~ 0.15 ~ (0.57)] P ~ (0.0003) ~ (3) ~ (-1) ~ (-1) ~ (-1) ~ (-1) ~ (0.66) ~ (-1) ~ (0.66) ~ (-1) ~ (-1) ~ (-1) ~ (0.66). The difference was statistically significant: Huangqi Jianzhong decoction was treated with pyrazole drugs alone, the relative risk was [RRX 2.60 ~ 95CII 1.73 ~ 3.91] P 0.00001, and Huangqi Jianzhong decoction combined with pyrazole was used as control. The relative risk (RRN 1.1095) was 1.01 / 1.21), and the difference was statistically significant. Conclusion Huangqi Jianzhong decoction has some advantages in the treatment of peptic ulcer, such as improving clinical effective rate, clinical cure rate, HP clearance rate and reducing recurrence rate.
【作者單位】： 天津中醫(yī)藥大學(xué);江蘇省人民醫(yī)院;
【基金】：國家自然科學(xué)基金資助項目(81373891)
【分類號】：R259

【相似文獻(xiàn)】

相關(guān)期刊論文 前10條

1 曹眾毅;毛偉松;;加減黃芪建中湯治療嘈雜40例療效觀察[J];中國中醫(yī)藥科技;2006年01期

2 譚紅英;;黃芪建中湯加減治療胃及十二指腸球部潰瘍36例[J];實用中醫(yī)內(nèi)科雜志;2006年06期

3 劉國英;;黃芪建中湯治療十二指腸球部潰瘍50例療效分析[J];哈爾濱醫(yī)藥;2008年04期

4 卿麗華;;黃芪建中湯治療慢性化膿性中耳炎療效分析[J];內(nèi)蒙古中醫(yī)藥;2012年16期

5 朱軼榮;;黃芪建中湯加減治療十二指腸球部潰瘍療效觀察[J];中國民康醫(yī)學(xué);2012年23期

6 秦巍;;黃芪建中湯治療脾胃虛寒型胃潰瘍45例[J];河南中醫(yī);2013年03期

7 李孟周;;黃芪建中湯的臨床應(yīng)用及藥理研究[J];中成藥;1990年11期

8 尹杰;滿冬梅;劉秀根;高永君;;黃芪建中湯治療36例肺癌放療中的并發(fā)癥[J];黑龍江醫(yī)藥;1992年06期

9 王清葉，，任忠禹，劉士霞;黃芪建中湯加減治療難治性消化性潰瘍[J];武警醫(yī)學(xué);1995年03期

10 李祥華,覃章元;黃芪建中湯治療十二指腸球部潰瘍療效分析[J];湖北省衛(wèi)生職工醫(yī)學(xué)院學(xué)報;1997年01期

相關(guān)會議論文 前9條

1 孫文學(xué);趙志彬;宋傳祖;梁志廣;;以黃芪建中湯為主治療十二指腸球部潰瘍58例報告[A];第二十次全國中西醫(yī)結(jié)合消化系統(tǒng)疾病學(xué)術(shù)會議暨消化疾病診治進(jìn)展學(xué)習(xí)班論文匯編[C];2008年

2 朱紅赤;楊曉燕;;黃芪建中湯治療兒童直立性調(diào)節(jié)障礙146例臨床分析[A];第25屆全國中醫(yī)兒科學(xué)術(shù)研討會暨中醫(yī)藥高等教育兒科教學(xué)研究會會議學(xué)術(shù)論文集[C];2008年

3 白雪峰;;黃芪建中湯治療消化性潰瘍機(jī)理應(yīng)用分析[A];中國中西醫(yī)結(jié)合學(xué)會第十四次全國消化系統(tǒng)疾病學(xué)術(shù)研討會論文匯編[C];2002年

4 段暉;柴玉瓊;高振鴻;;黃芪建中湯治療十二指腸潰瘍臨床體會[A];中華中醫(yī)藥學(xué)會脾胃病分會第二十四次全國脾胃病學(xué)術(shù)交流會論文匯編[C];2012年

5 孫萬岫;;黃芪建中湯、一貫煎治療虛性胃痛探討(摘要)[A];第九次全國中西醫(yī)結(jié)合虛證與老年病學(xué)術(shù)會議論文集[C];2007年

6 宋梅蘭;;黃芪建中湯治療十二指腸潰瘍體會[A];甘肅省中醫(yī)藥學(xué)會第五次會員代表大會、甘肅省針灸學(xué)會第三次會員代表大會暨學(xué)術(shù)研討會論文匯編[C];2006年

7 王繼祥;;黃芪建中湯加味治療慢性胃炎72例[A];全國中西醫(yī)結(jié)合教育學(xué)術(shù)研討會論文集[C];2000年

8 宋紅;王穎;鄭東升;鄭小偉;李春雯;;脾氣虛證大鼠GAS基因表達(dá)及加味黃芪建中湯的干預(yù)作用[A];全國第十二次中醫(yī)診斷學(xué)術(shù)年會論文集[C];2011年

9 孫萬岫;;虛性胃病的病機(jī)與治療探討[A];第二十一屆全國中西醫(yī)結(jié)合消化系統(tǒng)疾病學(xué)術(shù)會議暨國家級中西醫(yī)結(jié)合消化系統(tǒng)疾病新進(jìn)展學(xué)習(xí)班論文匯編[C];2009年

相關(guān)重要報紙文章 前10條

1 江蘇泰州 武簡侯;黃芪建中湯證論[N];上海中醫(yī)藥報;2013年

2 陳寶貴名中醫(yī)工作室 天津中醫(yī)藥大學(xué)附屬武清中醫(yī)院 張玉嶺;黃芪建中湯治虛寒胃痛[N];中國中醫(yī)藥報;2013年

3 河北省清苑縣中醫(yī)醫(yī)院 魏文浩 北京中醫(yī)藥大學(xué)東方學(xué)院 魏i

本文編號：2004243