發(fā)布時間：2018-06-05 17:18

  本文選題：同病異治 + 實證研究　； 參考：《北京中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：本論文共分三個部分:文獻綜述、理論研究、實驗研究。文獻綜述部分,通過整理古代醫(yī)籍中有關(guān)"同病異治"的論述以及近年的研究成果,疏理"同病異治"的理論源流,分析"同病異治"的研究進展與不足。理論研究部分,從多個角度對《傷寒雜病論》中"同病異治"的治療原則進行分析,發(fā)現(xiàn)"同病—異證—異方"的"同病異治"的解讀并不是"同病異治"的全部內(nèi)涵,"同病—同證—異方"是有其可能性的,至少是不矛盾的,其理論和臨床價值不可被忽略。實驗研究部分,以《金匱要略》"夫短氣,有微飲,當從小便去之,苓桂術(shù)甘湯主之,腎氣丸亦主之"為例,從生物學(xué)角度對"同病—同證—異方"的"同病異治"解讀進行實驗驗證。實驗研究方面,分兩個部分逐步驗證:第一部分基于氣道黏液高分泌大鼠模型的苓桂術(shù)甘湯與腎氣丸同病異治之作用比較研究目的:觀察苓桂術(shù)甘湯與腎氣丸對氣道黏液高分泌模型大鼠通氣功能的影響是否有差異。方法:以丙烯醛霧化吸入方式復(fù)制氣道黏液高分泌大鼠模型,在造模2周后,將大鼠隨機分為模型組、苓桂術(shù)甘湯組、腎氣丸組。第3周開始灌胃相應(yīng)中藥煎液,持續(xù)4周。模型組與正常組以等量純凈水灌胃。4周后,檢測各組大鼠的肺功能及動脈血氣并取肺組織按常規(guī)方法HE染色,進行病理觀察。結(jié)果:肺功能與動脈血氣檢測結(jié)果與正常組比較,模型組大鼠FVC、FEV1、FEV1/FVC下降(P0.05);動脈血pH、PaO2、SaO2下降,PaCO2升高(P0.05)。提示經(jīng)過丙烯醛霧化后大鼠氣道阻力增加,存在氣流受限和通氣功能障礙。與模型組比較,苓桂術(shù)甘湯組、腎氣丸組大鼠肺功能和動脈血氣均有改善(P0.05)。苓桂術(shù)甘湯組與腎氣丸組比較,FVC、FEV1、FEV1/FVC、pH、PaO2、SaO2、PaCO2差異不具有統(tǒng)計學(xué)意義(P0.05)。提示苓桂術(shù)甘湯與腎氣丸均可改善氣道黏液高分泌模型大鼠的通氣功能,且兩方作用效果差異不顯著。肺組織病理觀察正常組大鼠肺組織可見各支氣管管壁、肺泡黏膜結(jié)構(gòu)較完整,肺組織有少量炎性細胞,支氣管管腔內(nèi)未見炎性滲出物,充血不明顯。模型組大鼠肺組織支氣管及肺泡黏膜不完整,杯狀細胞和黏液腺肥大、增生,分泌亢進,阻塞支氣管。肺泡結(jié)構(gòu)紊亂,肺泡腔擴大、融合。支氣管管壁和肺泡有以中性粒細胞為主的大量炎性細胞浸潤。苓桂術(shù)甘湯組、腎氣丸組大鼠支氣管壁也有杯狀細胞和黏液腺肥大、增生,肺泡腔擴大、破裂、結(jié)構(gòu)紊亂,炎性細胞浸潤等,但與模型組相比病變程度較輕。結(jié)論:從本實驗研究結(jié)果來看,苓桂術(shù)甘湯與腎氣丸均能改善氣道黏液高分泌模型大鼠的通氣功能,即可"同病異治"。第二部分基于氣道黏液高分泌大鼠模型的苓桂術(shù)甘湯與腎氣丸同病異治之內(nèi)涵研究目的:探討苓桂術(shù)甘湯與腎氣丸改善氣道黏液高分泌模型大鼠通氣功能的作用機制。方法:造模、給藥方法、肺功能檢測、動脈血氣分析、肺組織HE染色(同第一部分)。分組增設(shè):苓桂術(shù)甘湯去苓桂組、腎氣丸去苓桂組、苓桂組、氫氯噻嗪組。用代謝籠收集大鼠24h尿液。用全自動分析儀檢測各組大鼠尿液中Na+、K+、Cl-濃度。ELISA法檢測大鼠尿液中AQP-2濃度。ELISA法檢測大鼠血清中PRA、AngⅡ、ALD濃度。結(jié)果:肺功能與動脈血氣檢測結(jié)果與正常組比較,模型組大鼠FVC、FEV1、FEV1/FVC下降(P0.05);動脈血pH、PaO2、SaO2下降,PaCO2升高(P0.05)。提示經(jīng)過丙烯醛霧化后大鼠氣道阻力增加,存在氣流受限和通氣功能障礙。與模型組比較,苓桂術(shù)甘湯組、腎氣丸組、苓桂組、氫氯噻嗪組大鼠肺功能和動脈血氣均有改善(P0.05);苓桂術(shù)甘湯去苓桂組、腎氣丸去苓桂組大鼠肺功能和動脈血氣均有改善(P0.05)。提示各組藥物均可改善模型大鼠的通氣功能,其中苓桂術(shù)甘湯組、腎氣丸組、苓桂組、氫氯噻嗪組作用顯著。苓桂術(shù)甘湯組與腎氣丸組比較,FVC、FEV1、FEV1/FVC、pH、PaO2、SaO2、PaCO2差異不具有統(tǒng)計學(xué)意義(P0.05)。提示苓桂術(shù)甘湯與腎氣丸均可改善氣道黏液高分泌模型大鼠的通氣功能,且兩方作用效果差異不顯著,即可"同病異治"。與苓桂術(shù)甘湯組比較,苓桂術(shù)甘湯去苓桂組大鼠通氣功能下降(P0.05)。與腎氣丸組比較,腎氣丸去苓桂組大鼠通氣功下降(P0.05)。提示茯苓、桂枝的配伍在苓桂術(shù)甘湯與腎氣丸改善模型大鼠通氣功能上有突出作用。以上檢測結(jié)果顯示,苓桂術(shù)甘湯與腎氣丸均可改善氣道黏液高分泌模型大鼠的通氣功能,且兩方作用效果差異不顯著,即可"同病異治"。當去除茯苓和桂枝后,苓桂術(shù)甘湯與腎氣丸改善模型大鼠通氣功能的作用均明顯減弱,而苓桂組改善模型大鼠通氣功能的作用又較為突出。因此,苓桂術(shù)甘湯與腎氣丸均可改善模型大鼠通氣功能且作用差異不顯著的原因可能是兩方中擁有相同的藥對——茯苓、桂枝。肺組織病理觀察正常組大鼠肺組織可見各支氣管管壁、肺泡黏膜結(jié)構(gòu)較完整,肺組織有少量炎性細胞,支氣管管腔內(nèi)未見炎性滲出物,充血不明顯。模型組大鼠肺組織支氣管及肺泡黏膜不完整,杯狀細胞和黏液腺肥大和增生,分泌亢進,阻塞支氣管。肺泡結(jié)構(gòu)紊亂,肺泡腔擴大、融合,支氣管管壁和肺泡有以中性粒細胞為主的大量炎性細胞浸潤。各給藥組大鼠支氣管杯狀細胞化生、黏液腺體增生、黏液分泌亢進,肺泡破裂、融合等皆有減輕,其中苓桂術(shù)甘湯組、腎氣丸組、苓桂組改善較為明顯。大鼠尿量檢測結(jié)果與正常組比較,模型組大鼠排尿量減少(P0.05)。提示氣道黏液高分泌模型大鼠存在尿液潴留。與模型組比較,苓桂術(shù)甘湯組、腎氣丸組、苓桂組、氫氯噻嗪組大鼠排尿量均增多(P0.05);苓桂術(shù)甘湯去苓桂組、腎氣丸去苓桂組大鼠排尿量增多(P0.05)。提示各組藥物均可改善模型大鼠尿液潴留。其中苓桂術(shù)甘湯組、腎氣丸組、苓桂組、氫氯噻嗪組作用顯著。苓桂術(shù)甘湯組與腎氣丸組比較,尿量差異不具有統(tǒng)計學(xué)意義(P0.05)。提示苓桂術(shù)甘湯與腎氣丸均可改善模型大鼠尿液潴留,且兩方作用差異不顯著。與苓桂術(shù)甘湯組比較,苓桂術(shù)甘湯去苓桂組大鼠排尿量減少(P0.05)。與腎氣丸組比較,腎氣丸去苓桂組大鼠排尿量減少(P0.05)。提示茯苓、桂枝的配伍在苓桂術(shù)甘湯與腎氣丸改善模型大鼠尿液潴留上有突出作用。尿液中AQP-2濃度檢測結(jié)果與正常組比較,模型組大鼠尿液中AQP-2排出量增多(P0.05)。提示氣道黏液高分泌模型大鼠腎臟AQP-2表達增加,尿液的生成減少。與模型組比較,苓桂術(shù)甘湯組、腎氣丸組、苓桂組、氫氯噻嗪組大鼠尿液中AQP-2濃度降低(P0.05);苓桂術(shù)甘湯去苓桂組、腎氣丸去苓桂組大鼠尿液中AQP-2濃度降低(P0.05)。提示各組藥物均可抑制模型大鼠AQP-2表達,其中苓桂術(shù)甘湯組、腎氣丸組、苓桂組、氫氯噻嗪組作用顯著。苓桂術(shù)甘湯組與腎氣丸組比較,尿液中AQP-2濃度差異不具有統(tǒng)計學(xué)意義(P0.05)。提示苓桂術(shù)甘湯與腎氣丸均可抑制腎臟AQP-2的表達,且兩方作用差異不顯著。與苓桂術(shù)甘湯組比較,苓桂術(shù)甘湯去苓桂組大鼠尿液中AQP-2濃度升高(P0.05)。與腎氣丸組比較,腎氣丸去苓桂組大鼠尿液中AQP-2濃度升高(P0.05)。提示茯苓、桂枝的配伍在苓桂術(shù)甘湯與腎氣丸抑制腎臟AQP-2的表達上有突出作用。血清中PRA、AngⅡ、ALD濃度檢測結(jié)果與正常組比較,模型組大鼠血清中PRA、AngⅡ、ALD濃度升高(P0.05)。提示氣道黏液高分泌模型大鼠RASS系統(tǒng)激活。與模型組比較,苓桂術(shù)甘湯組、苓桂組大鼠血清中PRA、AngⅡ、ALD濃度降低(P0.05);腎氣丸組PRA、AngⅡ降低(P0.05),ALD降低(P0.05);苓桂術(shù)甘湯去苓桂組、腎氣丸去苓桂組、氫氯噻嗪組大鼠血清中PRA、AngⅡ、ALD濃度降低(P0.05)。提示各組藥物均可抑制RASS系統(tǒng)激活,其中苓桂術(shù)甘湯組、苓桂組作用顯著。苓桂術(shù)甘湯組與腎氣丸組比較,PRA、AngⅡ、ALD濃度差異均不具有統(tǒng)計學(xué)意義(P0.05)。提示苓桂術(shù)甘湯與腎氣丸均可抑制RASS系統(tǒng)激活,且兩方作用差異不顯著。與苓桂術(shù)甘湯組比較,苓桂術(shù)甘湯去苓桂組大鼠血清中PRA、AngⅡ、ALD濃度升高(P0.05);與腎氣丸組比較,腎氣丸去苓桂組大鼠血清中PRA、AngⅡ濃度升高(P0.05),ALD濃度升高(P0.05)。提示茯苓、桂枝的配伍在苓桂術(shù)甘湯抑制RASS系統(tǒng)激活上有突出作用。尿液中Na+、K+、Cl-濃度檢測結(jié)果與正常組比較,模型組大鼠尿液中Na+、Cl-濃度降低、K+濃度升高(P0.05)。提示模型組大鼠尿液重吸收增加。與模型組比較,苓桂術(shù)甘湯組、腎氣丸組、苓桂組大鼠尿液中Na+、Cl-濃度升高,K+濃度降低(P0.05);苓桂術(shù)甘湯去苓桂組、氫氯噻嗪組大鼠尿液中Na+、Cl-濃度升高(P0.05)。K+濃度降低(P0.05);腎氣丸去苓桂組大鼠尿液中Na+、Cl-濃度升高,K+濃度降低(P0.05)。提示各組藥物均可抑制尿液重吸收,而苓桂術(shù)甘湯組、腎氣丸組、苓桂組作用更為顯著。苓桂術(shù)甘湯組與腎氣丸組比較,Na+、K+、Cl-濃度差異均不具有統(tǒng)計學(xué)意義(P0.05)。提示苓桂術(shù)甘湯與腎氣丸均可抑制尿液重吸收,且兩方作用差異不顯著。與苓桂術(shù)甘湯組比較,苓桂術(shù)甘湯去苓桂組大鼠尿液中Na+、Cl-濃度降低(P0.05),K+濃度升高(P0.05);與腎氣丸組比較,腎氣丸去苓桂組大鼠尿液中Na+、Cl-濃度降低,K+濃度升高(P0.05)。提示茯苓、桂枝的配伍在腎氣丸抑制尿液重吸收上有突出作用。綜合分析以上檢測結(jié)果,氣道黏液高分泌模型大鼠尿量明顯減少,苓桂術(shù)甘湯與腎氣丸均可通過調(diào)節(jié)AQP-2的表達、腎素-血管緊張素-醛固酮系統(tǒng)等途徑增加模型大鼠的尿量,且茯苓、桂枝的配伍在此作用中占有突出地位。結(jié)論:苓桂術(shù)甘湯與腎氣丸均可改善氣道黏液高分泌模型大鼠的通氣功能的原因可能是兩方均有促進模型大鼠尿液排泄的作用,即仲景所言"當從小便去之"。
[Abstract]:This paper is divided into three parts: literature review, theoretical research, experimental research and literature review. By sorting out the theories of "disease and hetero treatment" in ancient medical books and research achievements in recent years, the theoretical origin of "same disease and hetero treatment" is ignored. The analysis of the treatment principle of "the same disease and different treatment" in the theory of disease has found that the interpretation of "the same disease and different treatment" is not the whole connotation of "the same disease and different treatment". The "same disease - the same evidence - different prescription" has its possibility, at least not contradictory, its theory and clinical value can not be ignored. There are two parts in the experimental study: the first part is the Gump soup and kidney qi, which is based on the mucus hypersecreting rat model of the airway. Objective: To observe whether there is a difference between the effect of Ling Gui Shu Gan Tang and Shenqi Pill on the ventilation function of the airway mucus hypersecretion model in rats. Methods: the airway mucus hypersecreting rat model was replicated with acrolein atomization inhalation. After 2 weeks, the rats were randomly divided into model group, Gump Decoction group, kidney qi, and kidney qi. After third weeks, the decoction of traditional Chinese medicine was administered for 4 weeks. The model group and the normal group were treated with the same amount of pure water for.4 weeks. The pulmonary function and arterial blood gas of the rats were detected and the lung tissue was stained by the routine method of HE. The results of lung function and arterial blood gas test were compared with the normal group, and the model group was FVC, FEV1, FEV1/FVC decreased (P0.05); arterial blood pH, PaO2, SaO2 decreased, PaCO2 increased (P0.05). It suggested that the airway resistance increased in rats after acrolein atomization, and there was airflow limitation and ventilation dysfunction. Compared with the model group, the lung function and arterial blood gas of the rats in the Luli Gump Decoction group and the kidney qi pill group were improved (P0.05). The difference between FVC, FEV1, FEV1/FVC, pH, PaO2, SaO2, PaCO2 is not statistically significant (P0.05). It is suggested that Gump Tang and Shenqi pills can improve the ventilation function of the airway mucus hypersecretion model rats, and there is no significant difference in the effect between the two parties. The lung tissue has a small number of inflammatory cells, no inflammatory exudation in the bronchial tube and no obvious congestion. The bronchial and alveolar mucous membrane in the lung tissue of the model group is incomplete, the goblet cells and mucous glands are hyperhypertrophic, hyperhyperplastic, obstructed bronchioles, alveolar structure disorder, alveolar cavity enlargement, fusion, bronchial tube wall and alveolus. A large number of inflammatory cells infiltrated by neutrophils. The bronchi and mucous glands of the rats in the Shenqi decoction group and the kidney qi pill group had hypertrophy, hyperplasia, alveolar cavity enlargement, rupture, structural disorder and inflammatory cell infiltration, but compared with the model group, the degree of pathological changes was lighter. Conclusion: from the results of the experimental study, Lilin Gump soup and kidney Qi pill can improve the ventilation function of the airway mucus hypersecretion model rats. The second part is based on the connotation of the connotations of the same disease of the Luli Gump soup and the kidney qi pill based on the airway mucus hypersecreting rat model. Methods: modeling, drug delivery, lung function test, arterial blood gas analysis, HE staining of lung tissue (the same first part). Group adding: Luli Gump decoction, Guangxi group, Shenqi Pill, Luli group, Luli group, hydrochlorothiazide group. The urine of rats was collected by metabolic cage. The urine Na+, K+, Cl- concentration in the urine of rats in each group were detected by.ELISA method. Test the concentration of PRA, Ang II and ALD in rat serum by detecting the concentration of AQP-2 in rat urine. Results: compared with the normal group, the results of lung function and arterial blood gas detection were compared with the normal group. The model group was FVC, FEV1, FEV1/FVC decreased (P0.05), and the arterial blood pH, PaO2, SaO2 decreased and increased. Compared with the model group, the lung function and arterial blood gas of the rats in the Luli Gump soup group, the kidney qi pill group, the Luli group and the hydrochlorothiazide group were improved (P0.05); the lung function and arterial blood gas of the rats in the Luli Gump Decoction and the Shenqi Pill to the Luli group were improved (P0.05). The ventilation function of rats in the group of Luli Gump soup, kidney qi pill group, Ling Gui group and hydrochlorothiazide group was significant. The difference of FVC, FEV1, FEV1/FVC, pH, PaO2, SaO2, PaCO2 was not statistically significant (P0.05) in the group of Luli Gump Decoction and kidney qi pill group. There was no significant difference in the effect of two parties. Compared with the Gump Decoction group of Luli Gump decoction, the ventilation function of the rats was decreased (P0.05). Compared with the kidney qi pill group, the Qi Qi pill of Shenqi Pill was decreased (P0.05). The results showed that the Luli Gump Decoction and Shenqi Pill could improve the ventilation function of the airway mucus hypersecretion model rats, and the difference of the effect of the two parties was not significant, which could be "the same disease and different treatment". After the removal of Poria and cinnamon branches, the effect of Luli Gump soup and kidney qi pills on the ventilation function of the model rats was improved. The effect of Luli Gump Decoction and kidney qi pill can improve the ventilation function of the model rats and the difference is not significant, which may be the same drug pair in the two parties - Poria cocos, cinnamon branch. Lung tissue pathology observation of lung tissue in the normal group of rats can be seen in the lung tissue. Tracheal tube wall, alveolar mucous membrane structure is more complete, lung tissue has a small number of inflammatory cells, no inflammatory exudation in the bronchial tube, no obvious congestion. Model group rats lung tissue bronchus and alveolar mucous membrane incomplete, goblet cells and mucous glands hypertrophy and hyperplasia, hypersecretion, obstruction of bronchi, alveolar structure disorder, alveolar cavity enlargement, fusion, The bronchial tube wall and the alveoli were infiltrated with a large number of inflammatory cells based on neutrophils. All the rats in the group were relieved of the goblet cell metaplasia, mucous gland hyperplasia, mucus secretion, alveolar rupture, and fusion, and the improvement of the Luli Gump soup group, the kidney qi pill group and the Lili group was more obvious. Compared with the model group, the urine retention in the model rats was reduced (P0.05). Compared with the model group, the urine volume of the rats in the Luli Gump soup group, the kidney qi pill group, the Lili group and the hydrochlorothiazide group increased (P0.05), and the amount of urination in the Luli Gump Decoction and the Shenqi Pill was increased (P0.05). Each group of drugs can improve the retention of urine in the model rats. In the group of Luli Gump decoction, the kidney qi pill group, the Luli group and the hydrochlorothiazide group, the difference of urine volume is not statistically significant (P0.05). The results suggest that the urine retention of the model rats can be improved by the Luli Gump Decoction and the kidney qi pill, and the effect of the two party is poor. Compared with the Gump Decoction group of Luli operation Gump Decoction group, the urine volume of the rats in the Gump Decoction of Gump decoction was reduced (P0.05). Compared with the kidney qi pill group, the urine volume of the kidney qi pill was reduced (P0.05). It suggested that the compatibility of the Poria cocos and cinnamon branch had a prominent effect on the urine retention of the model rats. The urine AQP-2 concentration was detected. Compared with the normal group, the amount of AQP-2 excretion in the urine of the model rats increased (P0.05). It was suggested that the expression of AQP-2 in the kidney of the airway mucus hypersecretion model increased and the formation of urine decreased. Compared with the model group, the concentration of AQP-2 in the urine of the rats in the Luli Gump soup group, the kidney qi pill group, the Lili group and the hydrochlorothiazide group decreased (P0.05). The concentration of AQP-2 in the urine of rats in Luling group of Luli group was reduced (P0.05). It was suggested that all the drugs could inhibit the expression of AQP-2 in the model rats, including the group of Luli Gump soup, the kidney qi pill group, the Luli group and the hydrochlorothiazide group. The difference of AQP-2 concentration in the urine of Luli Gump Decoction group and the kidney qi pill group was not statistically significant (P0.05). It is suggested that the expression of AQP-2 in kidney can be inhibited by Ling Gui Shu Gan Tang and Shenqi Pill, and the difference between the two parties is not significant. Compared with the Gump Decoction group of Luli Gump decoction, the concentration of AQP-2 in the urine of the rats in the Gump Decoction of Gump decoction is increased (P0.05). Compared with the Shenqi Pill group, the concentration of AQP-2 in the urine of the rats in the rats of the kidney qi pill is higher (P0.05). Compared with the normal group, the serum concentrations of PRA, Ang II, and ALD were compared with the normal group, and the serum concentration of PRA, Ang II and ALD increased (P0.05) in the model group. The results showed that the RASS system in the model rats was activated by the model group. The comparison between the model group and the model group, Lili Gump soup group, Lili and laurel, was compared with the model group. Group PRA, Ang II, ALD concentration decreased (P0.05), kidney qi pill group PRA, Ang II reduction (P0.05), ALD reduction (P0.05); Luli Gump decoction, Guangxi group, Shenqi Pill to Luli group, hydrochlorothiazide group rats serum PRA, Ang II, ALD concentration decreased. Compared with the group of Shenqi Pill, PRA, Ang II and ALD concentration were not statistically significant (P0.05). It was suggested that Gump Tang and Shenqi pills could inhibit the activation of RASS system, and the difference between the two parties was not significant. Compared with the Gump Decoction group of Luli operation Gan Tang Group, the serum of PRA, Ang II and ALD concentration in the Gump Decoction of Gump Decoction of Gump Decoction were PRA, Ang II, ALD concentration. Du Shenggao (P0.05); compared with the Shenqi Pill group, the concentration of PRA, Ang II in the serum of the rats in the kidney qi pill and the concentration of Ang II increased (P0.05), and the concentration of ALD increased (P0.05). It suggested that the compatibility of cassia twig was prominent in the inhibition of RASS system activation in the Luli Gump soup. The results of the urine Na+, K+, Cl- concentration were compared with the normal group, and the urine of the model rats was Na+, The concentration of Cl- decreased and the concentration of K+ increased (P0.05). It was suggested that the urine reabsorption of rats in the model group increased. Compared with the model group, the urine of Luli Gump soup group, kidney qi pill group and Luli group increased the urine Na+, Cl- concentration and K+ concentration decreased (P0.05); the concentration of Na+ in urine in the urine of the hydrochlorothiazide group and the.K+ concentration (P0.05) decreased (P0.05).K+ (P) (P) (P0.05).K+ concentration (P) was reduced (P) 0.05): the concentration of Na+, Cl- and K+ in the urine of Shenqi Pill were increased and the concentration of K+ decreased (P0.05). It was suggested that the drug can inhibit the reabsorption of urine, and the effect of Luli Gump Decoction group, kidney qi pill group and Luli group was more significant. The difference of Na +, K+ and Cl- concentration was not statistically significant (P0.05) in the Luli Gump Decoction group and the kidney qi pill group (P0.05). GUI Zhu Gan Tang and Shenqi Pill can inhibit the reabsorption of urine, and the difference between the two parties is not significant. Compared with the Luli Gump Decoction group, the concentration of Na+, Cl- in the urine of Gump Decoction of Luli Gump Decoction (P0.05) and the concentration of K+ increased (P0.05), and the concentration of Na+, Cl- in the urine of Shenqi Pill and the concentration of Cl- in the rats of the kidney qi pill was lower, and the concentration of K+ increased (P0.0). 5) suggest that Poria, cinnamon branch has a prominent role in the inhibition of urine reabsorption by Shenqi Pill. Comprehensive analysis of the results of the above detection results, the urine volume of the airway mucus hypersecretion model rats significantly reduced, Luli Gump soup and kidney qi pills can be regulated by the expression of AQP-2, renin angiotensin aldosterone system and other ways to increase the urine of model rats In addition, the combination of tuckahoe and cinnamon branch plays a prominent role in this role. Conclusion: the reason that Luli Gump Decoction and kidney qi pill can improve the ventilation function of the rat model of airway mucus hypersecretion may be that the two parties have the effect of promoting the urine excretion of model rats, that is, Zhong Jing said "go from the urine."
【學(xué)位授予單位】：北京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R222.3

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