本文選題：穴位敷貼 + 慢性穩(wěn)定性心絞痛�。� 參考：《成都中醫(yī)藥大學》2016年碩士論文

【摘要】：目的：本研究以慢性穩(wěn)定性心絞痛患者為研究對象,采用隨機對照的方法,評價穴位敷貼治療慢性穩(wěn)定性心絞痛患者的臨床療效和安全性,為穴位敷貼治療慢性穩(wěn)定性心絞痛的臨床決策和臨床治療方案的優(yōu)化提供有力證據(jù)。方法：將納入試驗的160例患者隨機分為藥物敷貼組(A組)和安慰貼對照組(B組),試驗組采用冠心蘇合香丸加減所制成的中藥穴位敷貼進行治療,對照組采用安慰貼治療,兩組均選取內關、膻中、心俞和厥陰俞,均單側取穴,左右交替使用；每周3次為一個療程,每一療程間隔2天,連續(xù)治療4個療程,共12次。分別于基線期、治療后(4周)、隨訪期(8周)對慢性穩(wěn)定性心絞痛患者情況進行評價。評價的主要指標為心絞痛發(fā)作次數(shù),次要指標包括心絞痛疼痛分級、VAS評分、硝酸甘油使用頻次、SAQ評分、試驗療效評價和試驗后癥狀改善情況等。結果：(1)本試驗完成良好,兩組分組均衡,基線狀況良好,具有可比性。(2)A組治療后與基線期相比,在心絞痛發(fā)作次數(shù)、心絞痛疼痛分級、VAS評分、硝酸甘油使用頻次、SAQ評分(心絞痛穩(wěn)定狀態(tài)、心絞痛發(fā)作狀況、治療滿意程度和疾病認知度)等方面差異具有統(tǒng)計學意義(P0.05)；在SAQ評分(軀體活動受限程度)方面差異不具有統(tǒng)計學意義(P0.05)；A組隨訪期與基線期比較,在心絞痛發(fā)作次數(shù)、心絞痛疼痛分級、VAS評分、硝酸甘油使用頻次、SAQ評分(軀體活動受限程度、心絞痛絞痛穩(wěn)定狀態(tài)、治療滿意程度和疾病認知度)方面差異具有統(tǒng)計學意義(P0.05)；在SAQ評分(心絞痛發(fā)作狀況)方面差異不具有統(tǒng)計學意義(P0.05)。(3)B組治療后與基線期比較,在心絞痛發(fā)作次數(shù)、VAS評分、硝酸甘油使用頻次、SAQ評分(疾病認知度)等方面差異不具有統(tǒng)計學意義(P0.05)；在SAQ評分(軀體活動受限程度、心絞痛絞痛穩(wěn)定狀態(tài)、心絞痛發(fā)作狀況和治療滿意程度)等方面差異具有統(tǒng)計學意義(P0.05)；B組隨訪期與基線期比較,在心絞痛發(fā)作次數(shù)、VAS評分、硝酸甘油使用頻次、SAQ評分(軀體活動受限程度、心絞痛穩(wěn)定狀態(tài))等方面差異不具有統(tǒng)計學意義(P0.05)：在SAQ評分(心絞痛發(fā)作狀況、治療滿意程度和疾病認知度)方面差異具有統(tǒng)計學意義(P0.05)。(3)治療后,A組與B組比較,在心絞痛發(fā)作次數(shù)、心絞痛疼痛分級、VAS評分、硝酸甘油使用頻次、SAQ評分(心絞痛絞痛穩(wěn)定狀態(tài)、心絞痛發(fā)作狀況、治療滿意程度和疾病認知度)等方面差異具有統(tǒng)計學意義(P0.05)；在SAQ評分(軀體活動受限程度)等方面差異不具有統(tǒng)計學意義(P0.05)；隨訪期,A組與B組比較,在心絞痛發(fā)作次數(shù)、心絞痛疼痛分級、VAS評分、硝酸甘油使用頻次、SAQ評分(軀體活動受限程度、心絞痛絞痛穩(wěn)定狀態(tài)、心絞痛發(fā)作狀況、治療滿意程度和疾病認知度)、試驗療效評價和癥狀改善情況等方面差異具有統(tǒng)計學意義(P0.05)。結論：以冠心蘇合香丸加減所制成的穴位敷貼對改善慢性穩(wěn)定性心絞痛患者臨床癥狀具有顯著效果,可改善患者的心絞痛發(fā)作次數(shù)、心絞痛疼痛分級、VAS評分、硝酸甘油使用頻次、SAQ評分等,在緩解患者心絞痛癥狀的同時,對患者生活質量的提高也起到了重要的作用；穴位敷貼是一種安全的治療手段,可作為慢性穩(wěn)定性心絞痛的防治的輔助措施。
[Abstract]:Objective: To evaluate the clinical efficacy and safety of Acupoint Application in the treatment of chronic stable angina pectoris patients with chronic stable angina, and to provide effective evidence for the treatment of chronic stable angina pectoris by Acupoint Application in the treatment of chronic stable angina pectoris. The 160 patients were randomly divided into drug application group (group A) and consolation group (group B). The experimental group was treated with Acupoint Application of Chinese medicine with Guanxin souxiang pill. The control group was treated with consolation paste, and the two groups were selected from Neiguan, Shan Zhong, Xinyu and Yueyin Yu. They were both unilateral and left and right. 3 times a week were used. A course of treatment, 2 days interval, 4 consecutive courses, 12 times. At baseline, after treatment (4 weeks), follow-up period (8 weeks) of patients with chronic stable angina pectoris. The main index of the evaluation was the frequency of angina pectoris, secondary indexes including angina pectoris classification, VAS score, frequency of nitroglycerin use, SAQ evaluation. Results: (1) the results were as follows: (1) the experiment was completed well, the two groups were balanced, the baseline was good and comparable. (2) after the treatment of group A, the number of angina pectoris, the classification of angina pain, the score of VAS, the frequency of nitroglycerin, the SAQ score (the stable state of angina pectoris, the heart of the heart) The differences in pain attack status, treatment satisfaction and disease recognition were statistically significant (P0.05), and there was no statistical significance in SAQ score (P0.05); in group A, the number of angina pectoris, angina pectoris grade, VAS score, frequency of nitroglycerin use, SA The difference in Q score (physical activity limitation, angina pectoris stability, treatment satisfaction and disease recognition) was statistically significant (P0.05), and there was no statistical significance in SAQ score (P0.05). (3) compared with the baseline period, the number of angina pectoris, the VAS score, and the Gump of nitric acid in the B group were compared with the B group. There was no statistical significance (P0.05) in the frequency of oil use, SAQ score (disease recognition) and other aspects. The difference in SAQ score (physical activity limitation, angina pectoris stability, angina pectoris condition and treatment satisfaction) was statistically significant (P0.05). Group B was compared with baseline period in angina pectoris attack. The number, VAS score, the frequency of nitroglycerin use, the SAQ score (the degree of physical activity limitation, the stable state of angina pectoris) were not statistically significant (P0.05): the difference between the SAQ score (angina pectoris condition, treatment satisfaction and disease recognition) was statistically significant (P0.05). (3) after the treatment, the A group was compared with the B group in the cardiac stranding. The number of pain attacks, angina pectoris classification, VAS score, frequency of nitroglycerin use, SAQ score (angina pectoris stable state, angina pectoris condition, treatment satisfaction and disease recognition) were statistically significant (P0.05), and there was no statistical significance in SAQ score (body activity limitation), and so on (P0.05 During the follow-up period, the A group was compared with the B group, including the frequency of angina pectoris, the classification of angina pain, the VAS score, the frequency of nitroglycerin, the SAQ score (the degree of physical activity limitation, the stable state of angina pectoris, the condition of angina pectoris, the condition of angina pectoris, the cognition of the disease, and the cognition of the disease), and the difference of the evaluation of the efficacy and the improvement of the symptoms. Statistical significance (P0.05). Conclusion: acupoint application made with the addition and subtraction of Guanxin Su Xiang pill has significant effect on improving the clinical symptoms of chronic stable angina patients. It can improve the frequency of angina pectoris, pain classification of angina pectoris, VAS score, frequency of nitroglycerin use, SAQ score and so on, in alleviating the symptoms of angina pectoris in patients. It also plays an important role in improving the quality of life of the patients, and acupoint application is a safe treatment method, which can be used as an auxiliary measure for the prevention and treatment of chronic stable angina.
【學位授予單位】：成都中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2016
【分類號】：R246.1

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