本文選題：槲寄生滴眼液 + 治療　； 參考：《中國醫(yī)院藥學(xué)雜志》2017年09期

【摘要】：目的:探究槲寄生滴眼液對治療圍絕經(jīng)期雌兔干眼癥的效果。方法:取健康雌兔36只將24只雌兔行雙側(cè)卵巢切除術(shù),處理后,將這24只受試兔按照隨機(jī)數(shù)字表法分為2組(每組12只,均為右眼):對生理鹽水組(A組)、槲寄生滴眼液組(B組),連續(xù)滴眼2個月,每日4次。剩余的12只雌兔(C組)打開腹腔,不切除卵巢,眼部不進(jìn)行任何處理,作為假手術(shù)組。分別于手術(shù)前、手術(shù)后1周、2周、1個月及2個月對受試兔行基礎(chǔ)淚液分泌(SIT)檢查、角膜熒光素染色(FL)評分、淚液蛋白測定及角膜共聚焦顯微鏡掃描。結(jié)果:A、B2組干預(yù)前SIT、FL相比,差異無統(tǒng)計學(xué)意義(P0.05),與假手術(shù)組比較,差異均有統(tǒng)計學(xué)意義(均P0.05);干預(yù)2個月后,假手術(shù)組SIT、FL評分較干預(yù)前沒有明顯變化(P0.05),而A、B組SIT、FL評分較干預(yù)前變化明顯,差異均有統(tǒng)計學(xué)意義(P0.05)。干預(yù)2個月后,B組與假手術(shù)組相比,差異無統(tǒng)計學(xué)意義(P0.05),而A組與假手術(shù)組相比,差異有統(tǒng)計學(xué)意義(P0.05)。A、B2組各時間點(diǎn)SIT、FL評分相比,差異均有統(tǒng)計學(xué)意義(P0.05)。A、B2組干預(yù)2個月后淚液總蛋白量、乳鐵蛋白、溶菌酶及淀粉酶活性相比,差異均有統(tǒng)計學(xué)意義(P0.05)。經(jīng)角膜共焦顯微鏡顯示:B組角膜上皮下神經(jīng)及角膜基質(zhì)層神經(jīng)干較直,與正常雌兔上皮下神經(jīng)比較數(shù)量稍有減少。而A組角膜上皮下神經(jīng)及角膜基質(zhì)層神經(jīng)干彎曲,數(shù)量明顯減少。結(jié)論:槲寄生滴眼液可有效減輕圍絕經(jīng)期雌兔干眼癥的癥狀和體征,應(yīng)用于圍絕經(jīng)期女性干眼癥治療有一定的臨床意義。
[Abstract]:Objective: to investigate the effect of mistletoe eye drops on peri-menopausal female rabbit dry eye. Methods: after bilateral ovariectomy was performed on 24 healthy female rabbits, the 24 rabbits were randomly divided into 2 groups (12 rabbits in each group). All of them were right eye: group A in normal saline group and group B in mistletoe eye drops were dripped continuously for 2 months, 4 times a day. The remaining 12 female rabbits were treated as sham-operated group. Before operation, 1 week, 1 month and 2 months after operation, the basic tear secretion test, corneal fluorescein staining (FLL) score, tear protein measurement and corneal confocal microscope scanning were performed. Results there was no significant difference between the two groups before intervention (P 0.05), but there was significant difference between the two groups (all P 0.05), and after 2 months of intervention, there was no significant difference between the two groups (P 0.05), and there was no significant difference between the control group and sham operation group (P 0.05). There was no significant change in the score of SITF in sham operation group compared with that before intervention (P 0.05), but the score of SITF in group A was significantly different from that in group A (P 0.05). Two months after intervention, there was no significant difference between group B and sham operation group (P 0.05), but the difference between group A and sham group was statistically significant. There were significant differences in the total protein content, lactoferrin, lysozyme and amylase activity in tears after two months of intervention. The corneal confocal microscopy showed that the corneal subepithelial nerve and the corneal stromal layer nerve trunk in group B were straight, and the number of the subcutaneous nerves was slightly decreased compared with the normal female rabbits. In group A, the number of corneal subcutaneous nerve and corneal stromal nerve trunk was significantly reduced. Conclusion: mistletoe eye drops can effectively relieve the symptoms and signs of peri-menopausal female rabbit dry eye, and it has certain clinical significance in the treatment of peri-menopausal female dry eye.
【作者單位】： 江西省人民醫(yī)院眼科臨床營養(yǎng)科;南昌大學(xué)第一附屬醫(yī)院眼科;廈門大學(xué)眼科研究所;
【基金】：國家自然科學(xué)基金資助(編號:81660158,81400372) 江西省自然科學(xué)基金(編號:20151BAB215016) 江西省科技支撐計劃項(xiàng)目(編號:20151BBG70223) 江西省衛(wèi)生計生委科技項(xiàng)目(編號:20161008)
【分類號】：R271.116
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本文編號：1973604