本文選題：功能性消化不良 + 餐后不適綜合征�。� 參考：《南京中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:通過運用導(dǎo)師自擬調(diào)肝和中湯治療餐后不適綜合征(PDS),觀察其臨床療效和患者生活質(zhì)量改善水平,為臨床治療PDS提供參考,并為推廣調(diào)肝和中法的應(yīng)用提供有力依據(jù)。方法:選擇符合本研究納入標(biāo)準(zhǔn)的60例PDS患者,隨機分為兩組。治療組30例,采用自擬調(diào)肝和中湯治療;對照組30例,采用莫沙必利片治療。兩組治療4周,共一個療程。治療結(jié)束后,觀察和記錄中醫(yī)證候總積分、各單項癥狀積分、HAMA/HAMD評分等在治療前后的變化,收集數(shù)據(jù)并進行統(tǒng)計分析,得出結(jié)論。結(jié)果:1.中醫(yī)證候療效比較:治療組總有效率93.33%,對照組總有效率70.00%。兩組治療后總有效率相比較,差異有統(tǒng)計學(xué)意義(P0.05),提示治療組總體療效優(yōu)于對照組。2.中醫(yī)證候總積分比較:治療后,兩組中醫(yī)證候總積分均明顯下降(P0.01),經(jīng)組間比較提示治療組的療效優(yōu)于對照組(P0.01)。3.主要癥狀療效比較:治療組治療餐后飽脹、早飽的總有效率分別為90.48%、87.50%,對照組依次為52.63%、47.06%,兩組比較差異有統(tǒng)計學(xué)意義(P0.05),提示治療組餐后飽脹、早飽療效優(yōu)于對照組。4.各單項癥狀積分比較:治療組各項癥狀積分經(jīng)治療后都有明顯改善(P0.01);對照組除燒心反酸癥狀無明顯改善外,其余各項癥狀較治療前都有所好轉(zhuǎn)(P0.01、P0.05)。各項癥狀對比來看,治療組餐后飽脹、早飽、上腹痛、惡心噯氣、燒心反酸及便溏不爽的療效明顯優(yōu)于對照組(P0.01、P0.05);而在飲食減少、兩脅脹滿、胸悶善太息等方面兩組療效無明顯差異(P0.05)。5.HAMD/HAMD評分比較:兩組各自評分與治療前比較都明顯降低(P0.01),治療組評分改善更明顯(P0.01)。結(jié)論:調(diào)肝和中法治療PDS能夠改善患者餐后飽脹、早飽等主要癥狀,對于惡心噯氣、便溏不爽等癥狀也有較好的療效,同時能降低焦慮、抑郁評分,調(diào)節(jié)不良情緒,且無不良反應(yīng)發(fā)生。調(diào)肝和中法治療PDS能夠獲得良好的臨床療效。
[Abstract]:Objective: to observe the clinical efficacy and quality of life of patients with PDS by using tutors' self-made Tiaogan decoction to treat the patients with postprandial discomfort syndrome (PHS), and to provide reference for clinical treatment of PDS, and to provide a strong basis for popularizing the application of liver regulation and Chinese medicine. Methods: 60 patients with PDS were randomly divided into two groups. 30 cases in the treatment group were treated with self-made Tiaogan he Zhong decoction and 30 cases in the control group were treated with mosapride tablets. The two groups were treated for 4 weeks with a course of treatment. After treatment, observe and record the total integral of TCM syndrome, every single symptom integral and Hama / Hamd score before and after treatment, collect data and make statistical analysis, and draw a conclusion. The result is 1: 1. Comparison of TCM syndromes efficacy: the total effective rate of treatment group 93.33, control group total effective rate 70.005. After treatment, the total effective rate of the two groups was significantly higher than that of the control group (P 0.05), indicating that the overall curative effect of the treatment group was better than that of the control group. 2. Comparison of the total integral of TCM syndromes: after treatment, the total integral of TCM syndromes in the two groups decreased significantly (P 0.01). The comparison between the two groups indicated that the curative effect of the treatment group was better than that of the control group (P 0.01). 3. Comparison of the main symptoms: the total effective rate of the treatment group was 90.48 and the total effective rate of early satiety was 90.48 and that of the control group was 52.63 and 47.06 respectively. The difference between the two groups was statistically significant (P0.05), suggesting that the treatment group was better than the control group in terms of post-meal fullness and early satiety. Comparison of individual symptom scores: after treatment, the symptom scores in the treatment group were significantly improved (P 0.01), while in the control group, the symptoms of reflux acid in the heart were not obviously improved, and the other symptoms were improved compared with those before the treatment. Compared with the symptoms, the curative effect of the treatment group on fullness after meal, early satiety, upper abdominal pain, nausea and belching, resuscitation of heart, acid reflux and loose stools was obviously better than that of the control group (P0.01 / P0.05N), while in the diet reduction, the two sides were full, There was no significant difference in the curative effect between the two groups in terms of chest tightness, good relief, etc. There was no significant difference in the curative effect between the two groups. 5. The score of Hamd / Hamd in the two groups was significantly lower than that before treatment, and the score of the treatment group was improved more obviously than that of the control group (P 0.01). Conclusion: regulating liver and treating PDS with Chinese medicine can improve the main symptoms such as fullness and early satiety after meal, and can also have good effect on nausea, belching, loose stools and other symptoms. Meanwhile, it can reduce the scores of anxiety and depression, and regulate the bad mood. No adverse reactions occurred. Regulating liver and treating PDS with Chinese medicine can obtain good clinical effect.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R259

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