發(fā)布時(shí)間：2018-06-01 05:11

  本文選題：益腎序貫法 + 體外受精-胚胎移植��； 參考：《山東中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:本研究旨在通過運(yùn)用二至天癸顆粒與參芪壽胎丸顆粒序貫療法,觀察補(bǔ)腎中藥對(duì)腎虛反復(fù)種植失敗患者的中醫(yī)證候積分、妊娠結(jié)局及外周血IL-17因子等方面的影響,以期為補(bǔ)腎中藥改善腎虛反復(fù)種植失敗患者的妊娠結(jié)局找到有利的理論根據(jù)。方法:選取行體外受精-胚胎移植治療的RIF患者66例,隨機(jī)數(shù)字表法產(chǎn)生治療組和對(duì)照組各33例,治療組FET當(dāng)周期在常規(guī)替代周期方案的基礎(chǔ)上,予二至天癸顆粒,內(nèi)膜轉(zhuǎn)化日后改用參芪壽胎丸顆粒至超聲下見原始心管搏動(dòng)日;對(duì)照組給予FET周期常規(guī)替代周期方案。觀察治療前后各組外周血IL-17的變化程度、腎虛證候積分變化、胚胎種植率、生化妊娠率及臨床妊娠率等。結(jié)果:治療組患者于內(nèi)膜轉(zhuǎn)化日外周血IL-17水平低于對(duì)照組(P0.05),FET14天外周血IL-17水平低于對(duì)照組(P0.01);中醫(yī)腎虛證候積分比較治療組低于對(duì)照組(P0.05);妊娠結(jié)局統(tǒng)計(jì)兩組患者胚胎種植率、生化妊娠率、臨床妊娠率,治療組均優(yōu)于對(duì)照組(P均0.05);IL-17水平與中醫(yī)腎虛證候積分呈正相關(guān)(P0.01)。結(jié)論:益腎序貫法系列方有效降低了腎虛RIF患者腎虛證候積分,緩解或消除了患者的腎虛癥狀,提高了患者的生活質(zhì)量;補(bǔ)腎中藥顯著降低了外周血清中IL-17的表達(dá),通過調(diào)節(jié)腎虛RIF患者的生殖免疫,改善了腎虛RIF患者的妊娠結(jié)局。
[Abstract]:Objective: the purpose of this study was to observe the effects of Yijitiangui granule and Shenqi Shouti pill on syndrome score, pregnancy outcome and IL-17 factor in peripheral blood of patients with kidney deficiency. In order to improve the kidney deficiency of patients with repeated implantation failure to find a favorable theoretical basis for pregnancy. Methods: 66 RIF patients treated with in vitro fertilization and embryo transfer were selected, 33 cases in the treatment group and 33 cases in the control group, respectively. The treatment group was treated with Erzhi Tiangui granule on the basis of routine replacement cycle. After intimal transformation, Shenqishou Titan Pill was used to the original cardiac tube pulsatile day under ultrasound, while the control group was given FET cycle routine replacement cycle regimen. The changes of IL-17 in peripheral blood, the integral change of kidney deficiency syndrome, embryo implantation rate, biochemical pregnancy rate and clinical pregnancy rate were observed before and after treatment. Results: the level of IL-17 in peripheral blood of the patients in the treatment group was lower than that in the control group on the day of intimal transformation, the level of IL-17 in the peripheral blood on the 14th day was lower than that in the control group (P 0.01), the score of syndrome of kidney deficiency in the treatment group was lower than that in the control group (P 0.05), and the embryo implantation rate in the two groups was counted. The biochemical pregnancy rate, clinical pregnancy rate and the level of IL-17 in the treatment group were better than those in the control group (P < 0.05) and there was a positive correlation between the level of IL-17 and the syndrome score of kidney deficiency in traditional Chinese medicine (P 0.01). Conclusion: Sequential method of tonifying kidney can effectively reduce the syndrome score of kidney deficiency in RIF patients, alleviate or eliminate the symptoms of kidney deficiency, and improve the quality of life of the patients, and the kidney tonifying herbs can significantly reduce the expression of IL-17 in peripheral serum. By regulating the reproductive immunity of RIF patients with kidney deficiency, the pregnancy outcome of RIF patients with kidney deficiency was improved.
【學(xué)位授予單位】：山東中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類號(hào)】：R271.9

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