本文選題：關(guān)聯(lián)規(guī)則 + 人工神經(jīng)網(wǎng)絡(luò)��； 參考：《廣州中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:通過對當(dāng)代中醫(yī)治療大腸癌的相關(guān)醫(yī)案文獻(xiàn)進(jìn)行整理和量化研究,以期探討中醫(yī)診治大腸癌的臨床規(guī)律和建立大腸癌證候預(yù)測模型,為臨床辨證治療大腸癌提供規(guī)范和參考。方法:1.通過全面檢索1979-2015年各大論文數(shù)據(jù)庫中收錄有關(guān)中醫(yī)藥治療大腸癌的文獻(xiàn),建立當(dāng)代中醫(yī)辨證治療大腸癌的文獻(xiàn)數(shù)據(jù)庫。對使用中藥、四診信息、證候等進(jìn)行頻數(shù)分析,對中藥與中藥、四診信息與中藥、證候與中藥進(jìn)行關(guān)聯(lián)分析。2.將收集到的大腸癌醫(yī)案分解為四診信息和證候模塊錄入Excel軟件中,并導(dǎo)入到IBM SPSS 19.0中,把"脾腎陽虛證"設(shè)置為因變量,把收集到四診信息作為因子,用其中70%的數(shù)據(jù)進(jìn)行建模訓(xùn)練,剩余30%的數(shù)據(jù)作為檢驗,運用多層感知器和徑向基函數(shù)兩種算法進(jìn)行大腸癌證候預(yù)測模型研究。結(jié)果:1.在137篇大腸癌醫(yī)案中共使用中藥203味,用藥總頻次1760次,常用中藥(用藥頻數(shù)15%)有24味。高頻中藥有白術(shù)、黃芪、茯苓、薏苡仁、白花蛇舌草、黨參、陳皮等,中藥主要集中分布在補氣藥、清熱藥、理氣藥、利水消腫藥、化濕藥、清熱解毒藥、清熱燥濕藥、補血藥。醫(yī)案共收錄大腸癌伴隨癥狀70種,共699頻次。大腸癌常見癥狀有腹痛、乏力、腹脹、便血、體瘦等主要伴隨癥狀;苔薄白、舌淡、苔白、脈細(xì)、舌質(zhì)紅為常見舌脈象。大腸癌篇文獻(xiàn)中,篩選出證型有29個,經(jīng)過歸類整理后得到8個證型。證候分型以氣血虧虛較多,其次是濕熱內(nèi)蘊、氣滯血瘀、淤毒內(nèi)阻、脾失健運。2.挖掘出中藥與中藥的關(guān)聯(lián)度較高的是:茯苓分別與白術(shù)、陳皮;木香分別與茯苓、白術(shù);黨參分別與茯苓、白術(shù);甘草分別與黃芪、白術(shù);陳皮分別與黃芪、白術(shù);白術(shù)與黃芪。四診與中藥的關(guān)聯(lián)統(tǒng)計結(jié)果:脈細(xì)、便溏、苔薄白、口苦、舌質(zhì)紅、口淡的大腸癌患者采用黃芪、白術(shù)等補氣藥較多。證候與中藥關(guān)聯(lián)結(jié)果:與脾腎陽虛密切相關(guān)的有黃芪、白術(shù)、陳皮、山藥和茯苓;與脾失健運密切相關(guān)的有黨參、茯苓、白術(shù);與脾虛濕困密切相關(guān)的有白芍、茯苓、陳皮和木香;與氣血虧虛相關(guān)密切相關(guān)的有黃芪、白術(shù)和薏苡仁;與氣滯血瘀密切相關(guān)的有黃芪、茯苓和白術(shù);與濕熱內(nèi)蘊密切相關(guān)的有甘草、薏苡仁、黃芪。3.基于多層感知器的大腸癌脾腎陽虛證候模型的訓(xùn)練組的樣本有92例,占67.2%;測試組的樣本有45例,占32.8%。樣本訓(xùn)練組的正確百分比為95.7%,測試組的正確百分比為93.3%,ROC曲線范圍值為0.972。基于徑向基函數(shù)的大腸癌脾腎陽虛證候模型的訓(xùn)練組的樣本有102例,占74.5%;測試組的樣本有35例,占25.5%。樣本訓(xùn)練組的正確百分比為90.2%,測試組的正確百分比為82.9%。ROC曲線范圍值為0.760。基于多層感知器的大腸癌脾腎陽虛證候預(yù)測模型計算出四診信息重要性前六位依次為苔薄脈沉細(xì)納呆腹脹脈細(xì)睡眠差,基于徑向基函數(shù)的大腸癌脾腎陽虛證候預(yù)測模型計算出四診信息重要性前六位依次為苔薄白腹脹舌淡體瘦納呆腹痛。結(jié)論:從用藥頻數(shù)分析,當(dāng)代中醫(yī)醫(yī)案處方中采用白術(shù)、黃芪、茯苓等24味藥物較多,其中以補氣藥、理氣藥、清熱藥和化濕藥較多;從四診信息上看,腹痛、乏力、腹脹、便血等為大腸癌患者的主要伴隨癥狀,證候頻數(shù)顯示大腸癌多以濕熱內(nèi)蘊、氣血虧虛為主。本研究中藥與中藥關(guān)聯(lián)分析研究結(jié)果顯示,置信度和支持度最高的藥對主要為補血藥與補氣藥形成組合藥對,理氣藥與補血藥組成藥對。從四診信息與中藥的關(guān)聯(lián)分析可知,脈細(xì)、便溏、苔薄白的大腸癌患者采用黃芪、白術(shù)、茯苓等補氣藥、利水消腫藥較多。從證候與中藥關(guān)聯(lián)分析可知,脾腎陽虛、脾失健運、脾虛濕困的患者應(yīng)多用白術(shù)、黃芪、茯苓等益氣健脾的中藥�；诙鄬痈兄鞯拇竽c癌脾腎陽虛證候預(yù)測模型ROC曲線范圍值較為接近1,說明此預(yù)測模型準(zhǔn)確性較高。可優(yōu)先考慮選用基于多層感知器的預(yù)測模型研究大腸癌證候的判別。
[Abstract]:Objective: to organize and quantify the relevant medical records of modern Chinese medicine for colorectal cancer, in order to explore the clinical rules of the diagnosis and treatment of large intestine cancer by traditional Chinese medicine and to establish the model of the prediction of the syndrome of large intestine cancer, and to provide a standard and reference for the treatment of colorectal cancer in clinical syndrome differentiation. 1. Literature on the treatment of colorectal cancer by traditional Chinese medicine and the establishment of a literature database for the treatment of large intestine cancer by contemporary TCM syndrome differentiation, frequency analysis on the use of traditional Chinese medicine, four diagnosis information and syndrome, and the correlation analysis of traditional Chinese medicine and traditional Chinese medicine, four diagnosis information and traditional Chinese medicine, syndrome and traditional Chinese medicine by.2., the medical cases of large intestine cancer are decomposed into four diagnosis information and syndrome modules In the Excel software, and imported into the IBM SPSS 19, the "spleen and kidney yang deficiency syndrome" was set as the dependent variable, and the four diagnosis information was collected as a factor, and 70% of the data were used to model the modeling training. The remaining 30% data were used as the test, and the multi-layer perceptron and radial basis function were used to study the prediction model of the syndrome of large intestine cancer. The results were as follows: 1. In 137 large bowel cancer cases, 203 flavors of traditional Chinese medicine were used, the total frequency of medicine was 1760 times, and the common Chinese medicine (frequency 15%) had 24 flavors. High frequency traditional Chinese medicine had Atractylodes macrocephala, astragalus, Poria, coix seed, white flower Hedyotis, Codonopsis, tangerine and so on. The Chinese traditional medicine was mainly concentrated in the medicine of Tonifying Qi, the antipyretic drugs, the antipyretic drugs, the antipyretic drugs, the antipyretic drugs, and the heat clearing dryness. A total of 70 types of colorectal cancer accompanied by symptoms, including abdominal pain, fatigue, abdominal distention, blood, thin body and other main symptoms, the common symptoms of large bowel cancer, such as thin white, pale tongue, whiteness, vein fine and tongue red as common tongue pulse. In the literature of large intestine cancer, 29 types were screened, and 8 syndromes were obtained after classification. There are more symptoms of Qi and blood deficiency, followed by damp heat accumulation, qi stagnation and blood stasis, silt resistance, spleen loss and transport of Chinese traditional medicine and traditional Chinese medicine have higher correlation degree: tuckahoe and Baizhu, tuckahoe, Atractylodes macrocephala respectively with Poria cocos and Atractylodes macrocephala; Radix Astragalus, Atractylodes rhizome, rhizoma Atractylodes, Rhizoma Atractylodes, Rhizoma Atractylodes; Rhizoma Atractylodes; Rhizoma Atractylodes; and Rhizoma Atractylodes, respectively, with Radix Astragalus, Atractylodes and.2. Astragalus. Four diagnosis and traditional Chinese medicine correlation statistical results: pulse thin, loose stool, thin white moss, oral pain, tongue quality red, and tonifying large intestine cancer patients with Astragalus, Atractylodes and other drugs. Closely related to the deficiency of Qi and blood, including Astragalus, Rhizoma Atractylodes and coix seed, closely related to deficiency of Qi and blood deficiency, which closely related to qi stagnation and blood stasis are Astragalus, Poria and Atractylodes, and there are Glycyrrhiza, coix seed and Huangqi.3., which are closely related to the damp and blood stasis, and the syndrome model of spleen and kidney yang deficiency syndrome of large intestine cancer based on multilayer perceptron The sample of the training group was 92, accounting for 67.2%; the sample of the test group had 45 cases, the correct percentage of the 32.8%. sample training group was 95.7%, the correct percentage of the test group was 93.3%, the ROC curve range was 0.972. based on the radial basis function of the spleen kidney yang deficiency syndrome model in 102 cases, accounting for 74.5%, and the sample of the test group. 35 cases, the correct percentage of the 25.5%. sample training group is 90.2%, the correct percentage of the test group is the 82.9%.ROC curve range value is 0.760. based on the multi-layer perceptron based on the spleen and kidney yang deficiency syndrome prediction model of the colorectal cancer. The first six places of the four diagnosis information are the thin dyke sinks and the abdominal distention pulse fine sleep poor, based on the radial basis function The prediction model of spleen and kidney yang deficiency syndrome of large intestine cancer calculated the importance of the first six cases of the four diagnosis information. Conclusion: from the analysis of the frequency of medicine, there are 24 kinds of drugs in the prescription of modern medicine, such as Atractylodes, astragalus, Poria, and so on. Information on information, abdominal pain, fatigue, abdominal distention, blood and so on as the main concomitant symptoms of large intestine cancer patients, the frequency of syndrome shows that large intestine cancer is more and more damp and hot, Qi and blood deficiency is the main. According to the correlation analysis between the four diagnosis information and the Chinese medicine, we can see that the patients with large intestine cancer with pulse thin, loose stool and thin white fur are filled with Astragalus, Atractylodes and poria, and there are many drugs for eliminating swelling. The ROC curve range of the prediction model of spleen and kidney yang deficiency syndrome based on multilayer perceptron is close to 1, which indicates that the prediction model is more accurate and the prediction model based on multilayer perceptron can be preferred to study the identification of the syndrome of colorectal cancer.
【學(xué)位授予單位】：廣州中醫(yī)藥大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2017
【分類號】：R273

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李施新;李遠(yuǎn);劉孟敏;;基于關(guān)聯(lián)規(guī)則和復(fù)雜系統(tǒng)熵聚類的100位全國名老中醫(yī)治療冠心病證治規(guī)律研究[J];中華中醫(yī)藥雜志;2016年04期

2 李悠然;谷云飛;陳邑岐;王浩;;四君子湯加減聯(lián)合化療對結(jié)直腸癌患者的Meta分析[J];中國實驗方劑學(xué)雜志;2016年06期

3 鄭樹;張?zhí)K展;黃彥欽;;結(jié)直腸癌研究30年回顧和現(xiàn)狀[J];實用腫瘤雜志;2016年01期

4 孫玉姣;李盼盼;原嘉民;徐福平;黃鸝;楊志敏;;國醫(yī)大師顏德馨含川芎膏方用藥規(guī)律的數(shù)據(jù)挖掘[J];時珍國醫(yī)國藥;2015年12期

5 熊江華;張昭;倪寅;李艷;;基于數(shù)據(jù)挖掘探討李濟(jì)仁教授治療慢性胃炎的用藥規(guī)律[J];中醫(yī)藥臨床雜志;2015年11期

6 李遠(yuǎn);劉盼英;李海濱;李濤;;運用數(shù)據(jù)處理技術(shù)探討原發(fā)性血小板增多癥的中醫(yī)辨證和用藥規(guī)律[J];醫(yī)學(xué)研究與教育;2015年05期

7 吳皓萌;徐志偉;敖海清;;基于數(shù)據(jù)挖掘的針灸治療慢性泄瀉的選穴規(guī)律研究[J];中華中醫(yī)藥雜志;2015年12期

8 劉宣;柴妮;韓植芬;劉慧;鄧皖利;周利紅;隋華;季青;李琦;;健脾解毒方對濕熱證結(jié)腸癌小鼠腫瘤血管新生的抑制作用[J];上海中醫(yī)藥大學(xué)學(xué)報;2015年06期

9 黃坤艷;程軍平;張世忠;張定棋;唐翠娟;喻歡;譚凌菁;梅志剛;;基于數(shù)據(jù)挖掘的糖尿病胃輕癱中醫(yī)用藥規(guī)律研究[J];時珍國醫(yī)國藥;2015年09期

10 郭立忠;;補益藥黨參的藥理作用與臨床應(yīng)用研究[J];中國衛(wèi)生標(biāo)準(zhǔn)管理;2015年22期

，

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