本文選題：扶正補(bǔ)土 + 抑郁癥　； 參考：《福建中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:觀察“扶正補(bǔ)土”針灸法對腦梗死后虛型抑郁癥患者的抑郁程度、中醫(yī)虛型郁證程度、血清5-HT與NE水平的影響,并通過分析其與觀察指標(biāo)的相關(guān)性,探討其可能的作用機(jī)制。方法:將符合納入標(biāo)準(zhǔn)的64例腦梗死后虛型抑郁癥患者,采用區(qū)組隨機(jī)化分成兩組隨機(jī)對照的方法研究,治療組予“扶正補(bǔ)土”針灸法治療,對照組予單純針刺法治療,均以14天為1個(gè)療程,共治療2個(gè)療程。在治療前、治療14天后、治療28天后分別對患者進(jìn)行漢密爾頓抑郁量表(HAMD)評分、中醫(yī)虛型郁證量表評分;在治療前、治療28天后對患者進(jìn)行血清5-羥色胺(5-HT)和去甲腎上腺素(NE)水平測定,并運(yùn)用SPSS20.0軟件進(jìn)行統(tǒng)計(jì)分析。結(jié)果:(1)治療組與對照組的漢密爾頓抑郁量表(HAMD)評分、中醫(yī)虛型郁證量表評分、血清5-HT和NE水平在治療后均有改善,與治療前相比,有顯著性差異(P0.01)。(2)治療14天后,治療組的漢密爾頓抑郁量表(HAMD)評分、中醫(yī)虛型郁證量表評分分別與對照組相比,無顯著性差異(P0.05)。(3)治療28天后,治療組的漢密爾頓抑郁量表(HAMD)評分、血清5-HT和NE水平分別與對照組相比,有顯著差異(P0.01);但組間中醫(yī)虛型郁證量表評分比較,無顯著性差異(P0.05)。(4)兩組治療前的漢密爾頓抑郁量表(HAMD)評分和中醫(yī)虛型郁證量表評分呈正相關(guān)(P0.05),5-HT和NE水平也呈正相關(guān)(P0.01),但這兩組之間呈負(fù)相關(guān)(P0.05)。(5)治療后,治療組的中醫(yī)虛型郁證量表評分與血清5-HT水平無明顯負(fù)相關(guān)(P0.05);對照組的中醫(yī)虛型郁證量表評分與血清NE水平無明顯負(fù)相關(guān)(P0.05)。結(jié)論:(1)“扶正補(bǔ)土”針灸法能夠顯著降低漢密爾頓抑郁量表(HAMD)和中醫(yī)虛型郁證量表的評分,且明顯提高血清中5-羥色胺(5-HT)和去甲腎上腺素(NE)的水平。(2)“扶正補(bǔ)土”針灸法對患者的抑郁程度和血清中NE的水平起到正相關(guān)的調(diào)節(jié)作用。(3)“扶正補(bǔ)土”針灸法無明顯不良反應(yīng),治療腦梗死后虛型抑郁癥患者安全、有效。
[Abstract]:Objective: to observe the effect of "Fuzheng Butu" acupuncture and moxibustion method on depression degree of deficiency type after cerebral infarction, depression degree of TCM deficiency type, serum 5-HT and NE levels, and to analyze their correlation with observed indexes. The possible mechanism of its action was discussed. Methods: 64 patients with depressive disorder after cerebral infarction were randomly divided into two groups. The treatment group was treated with acupuncture and moxibustion method of "Fuzheng Butu" and the control group was treated with simple acupuncture. All patients were treated with 14 days as a course of treatment. Before treatment, 14 days after treatment, 28 days after treatment, the patients were evaluated with Hamilton Depression scale (Hamd), TCM deficiency Depression scale (TCM), before treatment, After 28 days of treatment, the serum serotonin 5-HT and noradrenaline (NE) levels were measured and analyzed by SPSS20.0 software. Results the scores of Hamilton Depression scale (Hamd), TCM deficiency Depression scale, Serum 5-HT and NE levels in the treatment group and the control group were improved after treatment, and there was significant difference between the treatment group and the control group after 14 days of treatment. There was no significant difference in the scores of Hamilton Depression scale (Hamd) and TCM deficiency Depression scale (TCM Depression scale) between the treatment group and the control group after 28 days of treatment, there was no significant difference in the scores of the treatment group and the control group (P < 0.05). After 28 days of treatment, the treatment group had the score of the Hamilton Depression scale (Hamd). The serum levels of 5-HT and NE were significantly different from those of the control group (P 0.01), but the scores of TCM deficiency depression scale were compared between the two groups. There was no significant difference between the two groups before treatment (P 0.05).) the scores of Hamilton Depression scale (Hamd) before treatment and the scores of TCM deficiency Depression scale were positively correlated with the levels of 5-HT and NE, but there was a negative correlation between the two groups after treatment, however, there was a negative correlation between the two groups after treatment. There was no significant negative correlation between TCM deficiency depression scale score and serum 5-HT level in the treatment group, and there was no significant negative correlation between the TCM deficiency depression scale score and the serum NE level in the control group. Conclusion the acupuncture and moxibustion method of "Fuzheng Butu" can significantly reduce the scores of Hamilton Depression scale (Hamd) and TCM deficiency Depression scale. The level of serotonin 5-HT) and noradrenaline (NEN) were significantly increased. (2) "Fuzheng Butu" acupuncture and moxibustion method has a positive correlation to the depression degree of patients and the level of NE in serum. 3) "Fuzheng Butu" acupuncture and moxibustion method "Fuzheng Butu" acupuncture and moxibustion method of "Fuzheng Butu" acupuncture and moxibustion method No obvious adverse reactions, It is safe and effective to treat depressive patients with deficiency type after cerebral infarction.
【學(xué)位授予單位】：福建中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R246.6

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王珍珍;張春紅;王麗;白瑋婧;;腦卒中后抑郁相關(guān)因素分析[J];河南中醫(yī);2016年11期

2 占道偉;羅開濤;茅利玉;高峰;錢立鋒;沈來華;方劍喬;;針刺配合康復(fù)訓(xùn)練治療卒中后抑郁的臨床研究[J];上海針灸雜志;2016年07期

3 岳琳;;頭針配合耳穴貼壓治療腦卒中后抑郁療效觀察[J];上海針灸雜志;2016年07期

4 于學(xué)平;孫桂萍;;調(diào)督通任針刺法治療中風(fēng)后抑郁療效觀察[J];上海針灸雜志;2016年03期

5 王非;楊晶;肖文華;李云芳;;電針耳穴結(jié)合中藥治療中風(fēng)后抑郁癥各證型臨床觀察[J];中國中醫(yī)急癥;2016年03期

6 章顯寶;晏啟祿;肖偉;;以“通督治郁針法”為主穴治療卒中后抑郁不同證型療效觀察[J];中醫(yī)藥學(xué)報(bào);2016年01期

7 杜建新;;郁證的中醫(yī)證治經(jīng)驗(yàn)[J];當(dāng)代醫(yī)學(xué);2016年01期

8 巴建全;王偉;;郁證辨治思路探頤[J];中華中醫(yī)藥雜志;2016年01期

9 張貴格;;中醫(yī)針?biāo)幗Y(jié)合治療中風(fēng)后抑郁癥62例[J];中醫(yī)臨床研究;2015年21期

10 楊晶;王非;肖文華;;針?biāo)幒嫌弥委熤酗L(fēng)后抑郁癥33例臨床觀察[J];中國中醫(yī)急癥;2015年07期

相關(guān)會(huì)議論文 前2條

1 陳昱文;曹澤標(biāo);周小青;陳娉婷;;中醫(yī)癥狀量化方法及其臨床應(yīng)用述評[A];第九次全國中西醫(yī)結(jié)合診斷學(xué)術(shù)研討會(huì)論文集[C];2015年

2 陸征宇;趙虹;張紅玉;;缺血性腦卒中后抑郁與中醫(yī)證型關(guān)系的研究[A];中華中醫(yī)藥學(xué)會(huì)全國第二次神志病學(xué)術(shù)年會(huì)論文集[C];2010年

相關(guān)博士學(xué)位論文 前1條

1 李清;中醫(yī)學(xué)“郁”的理論研究[D];中國中醫(yī)科學(xué)院;2010年

相關(guān)碩士學(xué)位論文 前6條

1 陳光艷;缺血性腦卒中患者中醫(yī)體質(zhì)、中醫(yī)證候類型、5-HT、NE與腦卒中后抑郁發(fā)病的關(guān)系研究[D];山東中醫(yī)藥大學(xué);2014年

2 陳小平;抑郁癥患者中醫(yī)不同辨證分型腦內(nèi)5-HT、NE、DA神經(jīng)遞質(zhì)變化規(guī)律的研究[D];北京中醫(yī)藥大學(xué);2014年

3 李辰瑤;眼針治療腦卒中后抑郁的臨床療效觀察[D];遼寧中醫(yī)藥大學(xué);2013年

4 汪振杰;不同證侯階段抑郁癥患者外周血神經(jīng)遞質(zhì)的臨床研究[D];北京中醫(yī)藥大學(xué);2012年

5 鄒超;腦卒中后抑郁的中醫(yī)病機(jī)及證型研究[D];山東中醫(yī)藥大學(xué);2011年

6 宋慧珠;針灸治療中風(fēng)文獻(xiàn)研究[D];南京中醫(yī)藥大學(xué);2010年

，

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