發(fā)布時(shí)間：2018-05-27 22:15

  本文選題：玄夏消癭湯 + 痰結(jié)血瘀�。� 參考：《黑龍江中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:試探玄夏消癭湯在痰結(jié)血瘀型橋本氏甲狀腺炎患者臨床上的療效及對(duì)血清IL-17的影響,并探求玄夏消癭湯對(duì)橋本氏甲狀腺炎的治療的可能作用機(jī)理。方法:選出60例門(mén)診診斷為痰結(jié)血瘀型橋本氏甲狀腺炎的患者,隨機(jī)性的分為治療組和對(duì)照組,每組各30例。治療組:給以玄夏消癭湯150ml每袋,每日早晚各1袋,餐后溫服;對(duì)照組:給以夏枯草顆粒一次1袋,每日服用2次,兩組均觀察12周。觀察治療前與治療后患者中醫(yī)證候積分,甲狀腺彩超的情況及自身免疫抗體測(cè)定(TPOAb、TGAb)的水平,細(xì)胞因子IL-17的水平,從而做出臨床療效評(píng)價(jià)。結(jié)果:1.治療后,治療組與對(duì)照組比較,中醫(yī)單項(xiàng)癥狀或體征積分明顯減少,具有顯著統(tǒng)計(jì)學(xué)差異(P0.05)。2.治療后,治療組患者甲狀腺體積與對(duì)照組比較明顯縮小,差異具有顯著統(tǒng)計(jì)學(xué)意義(P0.05)。3.治療后,兩組患者組內(nèi)比較IL-17水平均有不同程度下降。但治療組患者IL-17的程度較對(duì)照組下降更顯著,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。4.治療后,治療組患者甲狀腺自身抗體水平較對(duì)照組下降明顯,差異具有統(tǒng)計(jì)學(xué)意義(P0.05)。5.治療后,兩組患者證候積分總有效率比較,治療組為93.33%,對(duì)照組為60.00%;Ridit分析后,前者即治療組患者中醫(yī)證候總療效明顯較后者即對(duì)照組更優(yōu),具有統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論:1.玄夏消癭湯治療痰結(jié)血瘀型橋本氏甲狀腺炎,可以明顯改善患者頸前喉結(jié)兩旁腫大及咽異物感、胸脅刺痛及脘腹痞悶的中醫(yī)臨床癥狀;2.玄夏消癭湯治療橋本氏甲狀腺炎,患者增大的甲狀腺體積明顯縮小;3.玄夏消癭湯治療橋本氏甲狀腺炎,可以減低患者甲狀腺自身抗體(TPOAb、TGAb);4.玄夏消癭湯治療橋本氏甲狀腺炎,可以減低患者外周血的IL-17,從而調(diào)節(jié)患者免疫功能,調(diào)節(jié)患者免疫功能為其達(dá)到治療HT的可能作用機(jī)制。
[Abstract]:Objective: to explore the clinical efficacy of Xuanxia Xiaoying decoction (XXXD) in treating Hashimoto's thyroiditis with phlegm and blood stasis type and its effect on serum IL-17, and to explore the possible mechanism of Xuanxia Xiaoying decoction (XXXD) in the treatment of Hashimoto's thyroiditis. Methods: 60 cases of Hashimoto's thyroiditis diagnosed as phlegm and blood stasis type were randomly divided into treatment group and control group with 30 cases in each group. The treatment group was given Xuanxia Xiaoying decoction (150ml) in each bag, 1 bag in the morning and evening after meal, while the control group was given 1 bag of Prunella subtilis granules once a day, 2 times a day, both groups were observed for 12 weeks. The TCM syndromes score, thyroid color Doppler ultrasound and autoimmune antibody were observed before and after treatment, and the levels of cytokines IL-17 were measured to evaluate the clinical efficacy. The result is 1: 1. After treatment, compared with the control group, the scores of single symptoms or signs in the treatment group were significantly reduced, with a significant statistical difference (P 0.05). 2. After treatment, the thyroid volume of the patients in the treatment group was significantly smaller than that in the control group, and the difference was statistically significant (P 0.05. 3). After treatment, the level of IL-17 decreased in different degree in both groups. However, the degree of IL-17 in the treatment group was significantly lower than that in the control group, and the difference was statistically significant (P 0.05. 4). After treatment, the level of thyroid autoantibodies in the treatment group was significantly lower than that in the control group, and the difference was statistically significant. After treatment, the total effective rate of syndromes integral was 93.33 in the treatment group and 60.00g in the control group. After Ridit analysis, the total curative effect of TCM syndrome in the former group was significantly better than that in the latter group (P 0.05). Conclusion 1. Xuanxia Xiaoying decoction in treating Hashimoto's thyroiditis with phlegm and blood stasis can obviously improve the clinical symptoms of patients with cervical anterior larynx enlargement and foreign body sensation of pharynx chest and hypochondriac prickle and abdominal and epigastric distension. Xuanxia Xiaoying decoction in the treatment of Hashimoto's thyroiditis patients increased thyroid volume significantly reduced by 3. Xuanxia Xiaoying decoction in treating Hashimoto's thyroiditis can reduce the thyroid autoantibody TPOAb and TGAbA4. Xuanxia Xiaoying decoction in treating Hashimoto's thyroiditis can reduce the level of IL-17 in peripheral blood of patients, thus regulate the immune function of patients, and regulate the immune function of patients as the possible mechanism for the treatment of HT.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類(lèi)號(hào)】：R259

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李方遠(yuǎn);劉曉玲;秦媛媛;郎琰;袁正潔;熊學(xué)瓊;;針灸治療橋本氏甲狀腺炎研究進(jìn)展[J];亞太傳統(tǒng)醫(yī)藥;2016年18期

2 白瑞;;中草藥陳皮及其在動(dòng)物生產(chǎn)中的應(yīng)用[J];河南畜牧獸醫(yī)(綜合版);2016年04期

3 王高元;費(fèi)忠東;;許芝銀治療橋本氏甲狀腺炎的經(jīng)驗(yàn)[J];江蘇中醫(yī)藥;2015年10期

4 陳孟麗;任獻(xiàn)青;;中醫(yī)聯(lián)合激素不同階段治療腎病綜合征辨證體會(huì)[J];中醫(yī)臨床研究;2014年04期

5 李杰;詹t$t$;段時(shí)振;周才新;;中藥玄參研究概況[J];湖北中醫(yī)雜志;2013年08期

6 董舒;常才;;超聲引導(dǎo)下甲狀腺細(xì)針穿刺活檢的研究與進(jìn)展[J];中華醫(yī)學(xué)超聲雜志(電子版);2013年06期

7 竇景云;于俊生;;夏枯草藥理作用及臨床應(yīng)用研究進(jìn)展[J];現(xiàn)代醫(yī)藥衛(wèi)生;2013年07期

8 李玲;陳曉雯;;耳穴埋豆法治療橋本甲狀腺腫30例[J];江西中醫(yī)學(xué)院學(xué)報(bào);2013年02期

9 李品;高天舒;;橋本甲狀腺炎中醫(yī)病名考——橋本甲狀腺炎中醫(yī)病名辨析[J];遼寧中醫(yī)藥大學(xué)學(xué)報(bào);2012年07期

10 陳方敏;彭萬(wàn)年;;中醫(yī)英語(yǔ)翻譯的“得信忘雅”與“得雅忘信”[J];環(huán)球中醫(yī)藥;2012年02期

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