本文選題：帕金森病 + 加味五虎追風(fēng)散�。� 參考：《廣西中醫(yī)藥大學(xué)》2016年碩士論文

【摘要】：目的:探討具有補(bǔ)腎活血、化痰熄風(fēng)功效的加味五虎追風(fēng)散治療帕金森病的臨床療效。方法:將2014年5月至2015年10月在廣西中醫(yī)藥大學(xué)第一附屬醫(yī)院老年病科和神經(jīng)內(nèi)科門(mén)診及住院治療的帕金森病患者110例隨機(jī)分組,按1:1比例隨機(jī)分配至對(duì)照組和治療組,每組各55例,對(duì)照組予口服西藥多巴絲肼片治療,治療組在對(duì)照組的基礎(chǔ)上加用加味五虎追風(fēng)散,兩組均治療3個(gè)月。治療前后分別觀察兩組的中醫(yī)證候量表評(píng)分、帕金森病統(tǒng)一評(píng)分量表(UPDRSⅡⅢ)、帕金森病改良Hoehn-Yahr分級(jí)、帕金森病生存質(zhì)量量表(PDQ-39)、生活滿意度(LSIB)評(píng)分、血清SOD、GSH-Px、MDA指標(biāo)變化。結(jié)果:(1)兩組治療后中醫(yī)證候評(píng)分比較,治療組較對(duì)照組明顯改善(P0.01);(2)UPDRSⅡⅢ評(píng)分組內(nèi)比較:兩組治療后均較治療前改善,差異有統(tǒng)計(jì)學(xué)意義(P0.05或P0.01);組間比較:治療后治療組在UPDRSⅡⅢ評(píng)分改善方面優(yōu)于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);(3)兩組Hoehn㤘Yahr分級(jí)治療前后均無(wú)明顯變化,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);(4)兩組治療后PDQ-39評(píng)分比較,治療組優(yōu)于對(duì)照組(P0.05);(5)兩組治療后LSIB評(píng)分比較,治療組明顯優(yōu)于對(duì)照組(P0.01);(6)兩組治療后血清SOD、GSH-Px活性比較,治療組優(yōu)于對(duì)照組(P0.01或P0.05);(7)兩組治療后血清MDA含量比較,治療組明顯優(yōu)于對(duì)照組(P0.01)。結(jié)論:具有補(bǔ)腎活血、化痰熄風(fēng)作用的加味五虎追風(fēng)散可明顯提高帕金森病的臨床療效,其作用機(jī)理可能與提高帕金森病患者血清SOD、GSH-Px的活性,將MDA控制在較低水平,使患者機(jī)體擁有更為理想的抗氧化能力有關(guān)。
[Abstract]:Objective: to explore the clinical effect of modified Wuhu Zafeng Powder (WHZF) on Parkinson's disease (PD) with the effect of tonifying kidney and activating blood circulation and eliminating phlegm and dispelling wind. Methods: from May 2014 to October 2015, 110 cases of Parkinson's disease were randomly divided into control group and treatment group, according to the proportion of 1:1, which were treated in Department of Geriatrics and Neurology, Department of Geriatrics and Neurology, first affiliated Hospital of Guangxi University of traditional Chinese Medicine. There were 55 cases in each group, the control group was treated by oral administration of dobutazid tablets, and the treatment group was treated with modified Wuhu zaifeng powder on the basis of the control group. The two groups were treated for 3 months. Before and after treatment, the scores of TCM syndromes scale, Parkinson's disease scale 鈪，

本文編號(hào)：1935583