本文選題：半夏消痞湯 + 脾胃濕熱��； 參考：《山西中醫(yī)學(xué)院》2016年碩士論文

【摘要】：目的:通過(guò)觀察半夏消痞湯聯(lián)合雷貝拉唑鈉腸溶片治療脾胃濕熱型痞滿(mǎn)病(慢性非萎縮性胃炎)的臨床療效及安全性,為運(yùn)城地區(qū)脾胃濕熱型痞滿(mǎn)病(慢性非萎縮性胃炎)提供比較有效的治療方案。方法:本課題共收集79例符合納入標(biāo)準(zhǔn)的合格受試對(duì)象,按隨機(jī)、對(duì)照的原則將其分為兩組,減去脫落病例,試驗(yàn)組最終收集33例,對(duì)照組最終收集35例。試驗(yàn)組給予半夏消痞湯聯(lián)合雷貝拉唑鈉腸溶片,對(duì)照組給予雷貝拉唑鈉腸溶片,療程均為4周。比較分析兩組患者治療前后的中醫(yī)證候、胃鏡及病理組織學(xué)變化。結(jié)果:1、中醫(yī)證候療效評(píng)價(jià)(1)兩組中醫(yī)證候療效比較,經(jīng)秩和檢驗(yàn),試驗(yàn)組療效高于對(duì)照組(P0.05)。(2)中醫(yī)證候總積分比較,與治療前組內(nèi)比較,兩組治療后均取得療效(P0.01);治療后進(jìn)行組間比較,試驗(yàn)組癥狀改善優(yōu)于對(duì)照組(P0.01)。2、單項(xiàng)中醫(yī)癥狀積分比較(1)與治療前組內(nèi)比較,試驗(yàn)組和對(duì)照組各項(xiàng)中醫(yī)癥狀均有顯著改善(P0.05)。(2)試驗(yàn)組在“脘腹痞滿(mǎn)”、“口苦口干”、“身重困倦”、“小便短黃”和“大便不暢”這五項(xiàng)的療效優(yōu)于對(duì)照組(P0.05)。3、胃鏡療效評(píng)價(jià)(1)內(nèi)鏡總積分比較,兩組治療后均優(yōu)于治療前(P0.01);治療后進(jìn)行組間比較,試驗(yàn)組胃鏡療效優(yōu)于對(duì)照組(P0.01)。(2)兩組對(duì)胃黏膜紅斑、糜爛、出血均有療效(P0.01)。試驗(yàn)組對(duì)黏膜糜爛的療效優(yōu)于對(duì)照組(P0.05),兩組在黏膜紅斑和黏膜出血的療效無(wú)差異(P0.05)。4、病理組織學(xué)療效評(píng)價(jià)(1)病理組織學(xué)積分比較,兩組在慢性炎癥和活動(dòng)性炎癥方面均有改善(P0.01),試驗(yàn)組對(duì)慢性炎癥的療效優(yōu)于對(duì)照組(P0.05),兩組對(duì)活動(dòng)性炎癥的療效無(wú)差異(P0.05)。(2)兩組對(duì)慢性炎癥和活動(dòng)性炎癥的臨床療效經(jīng)秩和檢驗(yàn),無(wú)統(tǒng)計(jì)學(xué)差異(P0.05)。5、安全性評(píng)價(jià)通過(guò)安全性指標(biāo)的觀測(cè),兩組治療期間未見(jiàn)明顯不良反應(yīng)。結(jié)論:1、在療效和中醫(yī)證候改善方面,半夏消痞湯聯(lián)合雷貝拉唑鈉腸溶片治療脾胃濕熱型痞滿(mǎn)病(慢性非萎縮性胃炎)優(yōu)于單純使用雷貝拉唑鈉腸溶片。2、在胃鏡檢查方面,半夏消痞湯聯(lián)合雷貝拉唑鈉腸溶片可改善患者胃黏膜紅斑、糜爛、出血,且在胃黏膜糜爛方面療效優(yōu)于單純使用雷貝拉唑鈉腸溶片。3、在病理組織學(xué)方面,半夏消痞湯聯(lián)合雷貝拉唑鈉腸溶片可降低慢性炎癥和活動(dòng)性炎癥反應(yīng)程度,且在慢性炎癥方面療效優(yōu)于單純使用雷貝拉唑鈉腸溶片。4、半夏消痞湯聯(lián)合雷貝拉唑鈉腸溶片治療運(yùn)城地區(qū)脾胃濕熱型痞滿(mǎn)(慢性非萎縮性胃炎),安全有效,值得臨床推廣。
[Abstract]:Objective: to observe the clinical efficacy and safety of Banxia Xiaopi decoction (Banxia Xiaopi decoction) combined with rabeprazole sodium enteric-coated tablets in the treatment of chronic non-atrophic gastritis (chronic non-atrophic gastritis) with damp-heat type of spleen and stomach. To provide a more effective treatment for chronic non-atrophic gastritis in Yuncheng area. Methods: a total of 79 eligible subjects were collected and divided into two groups according to the principle of randomization and control. 33 cases were collected in the experimental group and 35 cases in the control group. The experimental group was given Banxia Xiaopi decoction combined with rabeprazole sodium enteric-coated tablets, and the control group was given rabeprazole sodium enteric-coated tablets for 4 weeks. The changes of TCM syndromes, gastroscopy and histopathology before and after treatment were compared between the two groups. Results: (1) the curative effect of TCM syndromes was compared between the two groups. By rank sum test, the curative effect of the experimental group was higher than that of the control group (P0.05. 0. 2) the total score of TCM syndromes was higher than that of the control group, and was compared with that before treatment. After treatment, the symptoms of the experimental group were improved better than that of the control group (P 0.01g 路2), and the scores of single TCM symptom were compared with those of the control group before and after the treatment (P 0.01), and compared with the control group (1) after the treatment, the improvement of symptoms in the experimental group was better than that in the control group. Each TCM symptom of the trial group and the control group were significantly improved (P0.05, P0.05, P0. 05, P < 0. 05).) in the experimental group, the abdominal distension was full, the mouth was bitter and the mouth was dry, and the body was heavy and sleepy. The curative effect of "short yellow urine" and "unobstructed stool" were better than that of the control group (P0.05J. 3) the total score of endoscopy was compared, and the two groups were better than P0.01before and after treatment. The effect of gastroscopy in the experimental group was better than that in the control group (P 0.01). The curative effect of the experimental group on mucosal erosion was better than that of the control group (P 0.05). There was no difference between the two groups in the curative effect of mucosal erythema and mucosal hemorrhage. There was no difference between the two groups in the treatment of chronic inflammation and active inflammation. The clinical efficacy of the two groups in chronic inflammation and active inflammation was tested by rank sum test. There was no significant difference between the two groups (P0.05. 5). The safety evaluation showed that there was no significant adverse reaction during the treatment period of the two groups. Conclusion in terms of curative effect and improvement of TCM syndromes, Banxia Xiaopi decoction combined with rabeprazole sodium enteric-coated tablet is superior to rabeprazole sodium enteric-coated tablet in the treatment of spleen and stomach damp-heat type fullness disease (chronic non-atrophic gastritis). Banxia Xiaopi decoction combined with rabeprazole sodium enteric-coated tablet can improve the gastric mucosal erythema, erosion and bleeding, and the curative effect in gastric mucosal erosion is better than that of rabeprazole sodium enteric-coated tablet .3. in histopathology, Banxia Xiaopi decoction is better than rabeprazole sodium enteric-coated tablet. Banxia Xiaopi decoction combined with rabeprazole sodium enteric-coated tablets can reduce the degree of chronic inflammation and active inflammatory reaction. The curative effect of chronic inflammation is better than that of rabeprazole sodium enteric-coated tablet. Banxia Xiaopi decoction combined with rabeprazole sodium enteric-coated tablet is safe and effective in treating spleen and stomach dampness and heat type (chronic non-atrophic gastritis) in Yuncheng area, and it is worth popularizing clinically.
【學(xué)位授予單位】：山西中醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2016
【分類(lèi)號(hào)】：R256.32

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