本文選題：加味丹葛止痛方 + 冠狀動脈支架植入術(shù)后心絞痛　； 參考：《廣西中醫(yī)藥大學》2017年碩士論文

【摘要】：目的:觀察有益氣活血功效的加味丹葛止痛方對冠心病經(jīng)皮冠狀動脈介入治療(percutaneous coronary intervention,PCI)術(shù)后氣虛血瘀證心絞痛患者的臨床療效。方法:選取2015年1月至2017年1月在我院心內(nèi)科就診的冠心病PCI術(shù)后氣虛血瘀證心絞痛患者67名,隨機分為觀察組和對照組,觀察組34例,對照組33例。觀察組在西醫(yī)常規(guī)治療組的基礎(chǔ)上加用加味丹葛止痛方進行臨床治療;對照組直接進行西藥常規(guī)治療。治療療程4周,隨訪3個月。主要從心絞痛發(fā)作次數(shù)和持續(xù)時間、西雅圖心絞痛量表評分、中醫(yī)癥候評分、硝酸甘油減停率和血脂等多項評價標準來對加味丹葛止痛方進行臨床療效評價。結(jié)果:治療前,兩組患者的年齡、性別、病程、BMI、既往史、過敏史、呼吸、脈搏、血壓、心絞痛發(fā)作次數(shù)和持續(xù)時間、西雅圖心絞痛量表、中醫(yī)癥候評分和血脂等指標在組間分布差異均無統(tǒng)計學意義(P0.05),具有可比性。經(jīng)4周治療后,觀察組對PCI術(shù)后氣虛血瘀證患者的胸痛、胸悶、心悸、氣短、神疲乏力等癥狀改善更加顯著;通過中醫(yī)癥候評分和西雅圖心絞痛量表評分比較,觀察組的改善優(yōu)于對照組,差異有統(tǒng)計學意義(P0.05);與對照組相比,觀察組的心絞痛發(fā)作的次數(shù)和持續(xù)時間和硝酸甘油減停率更有改善,差異有統(tǒng)計學意義(P0.05)。治療后,與對照組比較,觀察組的血脂中TC和LDL-C明顯降低,HDL-C明顯升高標改善更明顯,差異有統(tǒng)計學意義(P0.05)。但治療后觀察組TG與對照組相比,差異無統(tǒng)計學意義(P0.05)。結(jié)論:加味丹葛止痛方聯(lián)合西藥對治療冠心病PCI術(shù)后氣虛血瘀證患者心絞痛有很好的療效,能夠明顯改善中醫(yī)癥候,減少心絞痛發(fā)作癥狀,改善血脂指標,且安全性高,可以廣泛應用于臨床推廣。
[Abstract]:Objective: to observe the clinical effect of Jiawei Dan GE Zhitong recipe, which is beneficial to qi and promoting blood circulation, on patients with angina pectoris due to qi deficiency and blood stasis after percutaneous coronary intervention. Methods: from January 2015 to January 2017, 67 patients with angina pectoris with Qi deficiency and blood stasis syndrome after PCI were randomly divided into observation group (n = 34) and control group (n = 33). Observation group on the basis of routine western medicine treatment group plus the treatment of Dan GE Zhitong prescription for clinical treatment; the control group directly for routine treatment of western medicine. The course of treatment was 4 weeks, followed up for 3 months. The clinical efficacy of Jiawei Dan GE Zhitong prescription was evaluated mainly from the times and duration of angina pectoris, the score of Seattle angina pectoris scale, the score of TCM symptom, the reduction of stopping rate of nitroglycerin and the blood lipid. Results: before treatment, age, sex, course of disease, history of BMI, history of allergies, respiration, pulse, blood pressure, number and duration of angina pectoris, Seattle angina scale, There was no significant difference in the distribution of TCM symptom scores and blood lipids between the two groups (P 0.05), which was comparable. After 4 weeks of treatment, the improvement of chest pain, chest tightness, palpitations, shortness of breath, fatigue and other symptoms in patients with Qi deficiency and blood stasis syndrome after PCI was more significant, and the scores of TCM symptoms and Seattle angina pectoris scale were compared. Compared with the control group, the times and duration of angina pectoris attack and the reduction rate of nitroglycerin in the observation group were better than those in the control group, and the difference was statistically significant (P 0.05). After treatment, compared with the control group, TC and LDL-C in the observation group were significantly lower than those in the control group. The increase of HDL-C was significantly improved in the observation group, and the difference was statistically significant (P 0.05). However, there was no significant difference in TG between the observation group and the control group after treatment (P 0.05). Conclusion: Jiawei Dan GE Zhitong recipe combined with western medicine has a good curative effect on angina pectoris of patients with Qi deficiency and blood stasis syndrome after PCI, can obviously improve TCM symptoms, reduce angina pectoris attack symptoms, improve blood lipid index, and have high safety. It can be widely used in clinical application.
【學位授予單位】：廣西中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R259

【參考文獻】

相關(guān)期刊論文 前10條

1 孫春霞;胡曉貞;陳麗娟;王俊麗;任芳;顏乾麟;;924例冠心病介入術(shù)后患者中醫(yī)證候分布調(diào)查[J];中國中醫(yī)急癥;2017年02期

2 朱洪斌;張崇泉;張煒寧;王風雷;;冠心通絡膠囊結(jié)合雙聯(lián)抗血小板藥物防治PCI術(shù)后支架內(nèi)再狹窄的臨床研究[J];心血管康復醫(yī)學雜志;2016年06期

3 李輝;魏玲;;腦心通膠囊聯(lián)合西藥治療PCI術(shù)后患者的臨床研究[J];遼寧中醫(yī)雜志;2016年10期

4 翟穎;沙樹偉;劉淑榮;;益氣養(yǎng)陰活血法治療冠狀動脈介入術(shù)后心絞痛的臨床研究[J];中國中醫(yī)藥現(xiàn)代遠程教育;2016年17期

5 黃迎春;馬麗榮;劉盼功;張明霞;;冠心病PCI術(shù)后應用參七湯對冠脈再狹窄的臨床預防干預效果觀察[J];世界中醫(yī)藥;2016年06期

6 侯禹辰;郭旭;蔣昆;張大慶;;穩(wěn)定性冠狀動脈疾病抗心肌缺血治療的新觀念[J];實用藥物與臨床;2016年08期

7 宋欣;;四逆湯加味方治療冠脈介入后心絞痛的療效觀察[J];中西醫(yī)結(jié)合心血管病電子雜志;2015年35期

8 王星;陳康寅;賈忠偉;浦奎;李聯(lián)社;;自擬活血益氣通脈飲用于急性心肌梗死冠脈介入治療的臨床觀察[J];中國中醫(yī)急癥;2016年07期

9 劉瑞坤;;中藥葛根治療心絞痛的療效觀察及其機制探討[J];中西醫(yī)結(jié)合心血管病電子雜志;2015年34期

10 蔡金明;;曲美他嗪片聯(lián)合地爾硫卓片治療心絞痛療效觀察[J];中西醫(yī)結(jié)合心血管病電子雜志;2016年12期

相關(guān)博士學位論文 前1條

1 胡文志;葛根素干預核因子-κB防治動脈粥樣硬化的實驗研究[D];蘇州大學;2011年

，

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