本文選題：清肺潤(rùn)燥湯 + 風(fēng)燥犯肺型��； 參考：《黑龍江中醫(yī)藥大學(xué)》2017年碩士論文

【摘要】：目的:通過觀察清肺潤(rùn)燥湯治療感染后咳嗽(風(fēng)燥傷肺型)患者的臨床癥狀的變化,評(píng)價(jià)其臨床療效,為中醫(yī)學(xué)治療感染后咳嗽提供臨床依據(jù)。方法:選擇黑龍江中醫(yī)藥大學(xué)附屬第一醫(yī)院呼吸科門診就診的70例感染后咳嗽患者隨機(jī)分為治療組(35例)和對(duì)照組(35例),治療組予清肺潤(rùn)燥湯劑治療,對(duì)照組予阿斯美(復(fù)方甲氧那明膠囊)治療,觀察療程均為7天,在治療后第3天和第7天比較兩組患者治療前后中醫(yī)證候療效及咳嗽頻度、咳嗽強(qiáng)度、咳痰、咽癢、口干、鼻燥等癥狀的改善情況,并在治療后7天進(jìn)行療效判定,比較和觀察清肺潤(rùn)燥湯治療前后的血清TNF-α水平及血清IL-8水平,客觀評(píng)價(jià)清肺潤(rùn)燥湯對(duì)治療感染后咳嗽(風(fēng)燥傷肺型)的臨床療效。結(jié)果:1、臨床療效方面:治療組總有效率為85.2%,對(duì)照組總有效率為81.2%,無統(tǒng)計(jì)學(xué)意義(P0.05),說明治療組在臨床療效方面與對(duì)照組療效相當(dāng)。2、主癥的比較:治療后患者的主要癥狀咳嗽頻度、咳嗽強(qiáng)度差異無統(tǒng)計(jì)學(xué)意義(P0.05),說明清肺潤(rùn)燥湯在主癥咳嗽的改善情況與西藥對(duì)照組療效相當(dāng),咳痰積分有明顯減輕,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。3、次癥的比較:對(duì)比治療后患者各次癥積分,其中咽癢積分無統(tǒng)計(jì)學(xué)意義(P0.05),口干積分有統(tǒng)計(jì)學(xué)意義(P0.05),鼻燥積分無統(tǒng)計(jì)學(xué)意義(P0.05)。4、治療7天,治療組痊愈4例,顯效12例,有效12例,無效5例,總有效率85.2%。對(duì)照組痊愈2例,顯效3例,有效21例,無效6例,總有效率81.2%。經(jīng)統(tǒng)計(jì)學(xué)分析,其差異具無統(tǒng)計(jì)學(xué)意義(P0.05)。5、治療7天后,治療組的血清TNF-α水平低于治療前,具有統(tǒng)計(jì)學(xué)意義(P0.05),治療組的血清IL-8的水平治療7天后低于治療前,具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:清肺潤(rùn)燥湯能明顯改善風(fēng)燥犯肺型感染后咳嗽患者治療前后的咳嗽、咳痰及口干積分,明顯提高患者的生活質(zhì)量,降低患者血清中腫瘤壞死因子-α及血清白介素-8的水平。患者在治療期間無明顯不良反應(yīng),是安全有效方法。
[Abstract]:Objective: to evaluate the clinical effect of Qingfei Runzao decoction (QFRD) in treating cough after infection (wind dryness and lung injury), and to provide clinical basis for the treatment of cough after infection in traditional Chinese medicine (TCM). Methods: seventy patients with cough after infection were randomly divided into treatment group (n = 35) and control group (n = 35). The treatment group was treated with Qingfei Runzao decoction. The control group was treated with Asmine (compound methoxifen capsule) for 7 days. On the 3rd and 7th day after treatment, the curative effect of TCM syndromes and cough frequency, cough intensity, expectoration, pharynx itch and dry mouth were compared between the two groups before and after treatment. The improvement of nasal dryness and other symptoms was evaluated 7 days after treatment. The levels of serum TNF- 偽 and serum IL-8 were compared and observed before and after treatment with Qingfei Runzao decoction. Objective to evaluate the clinical effect of Qingfei Runzao decoction on cough after infection (wind dryness injury lung type). Results: the total effective rate of the treatment group was 85.2 and the total effective rate of the control group was 81.2. There was no significant difference between the treatment group and the control group (P 0.05), which indicated that the curative effect of the treatment group was equal to that of the control group. The comparison of the main symptoms and cough frequency after treatment showed that the treatment group had the same curative effect as the control group. The difference of cough intensity was not statistically significant (P 0.05), which indicated that Qingfei Runzao decoction had the same curative effect as the western medicine control group, and the score of expectoration was obviously alleviated. The difference was statistically significant (P 0.05). 3. Comparison of symptoms: there were no significant differences in the scores of pharynx itching, dry mouth, nasal dryness and nasal dryness. After 7 days of treatment, 4 cases were cured in the treatment group, and there was no significant difference in the scores of pharynx itch and dry mouth (P 0.05), and there was no significant difference in the score of nasal dryness for 7 days after treatment, 4 cases in the treatment group were cured. The total effective rate was 85.2%. In the control group, 2 cases were cured, 3 cases were markedly effective, 21 cases were effective and 6 cases were ineffective. The total effective rate was 81.2%. After 7 days of treatment, the serum level of TNF- 偽 in the treatment group was lower than that before treatment and had statistical significance (P 0.05). The level of serum IL-8 in the treatment group was lower than that before treatment 7 days after treatment, and had statistical significance. Conclusion: Qingfei Runzao decoction can obviously improve the score of cough, expectoration and dry mouth before and after treatment, and improve the quality of life of the patients. The serum levels of TNF-偽 and IL-8 were decreased. There is no obvious adverse reaction during the treatment, so it is a safe and effective method.
【學(xué)位授予單位】：黑龍江中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R256.11

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